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  1. Artikel ; Online: Ranking of Pentagonal Neutrosophic Numbers and its Applications to solve Assignment Problem

    K.Radhika / K.Arun Prakash

    Neutrosophic Sets and Systems, Vol 35, Pp 464-

    2020  Band 477

    Abstract: Introduction of Neutrosophic sets and Neutrosophic numbers paves a way to handle uncertainty more effectively. In this paper we propose a new approach for ranking neutrosophic number by using its magnitude. We develop an algorithm for the solution of ... ...

    Abstract Introduction of Neutrosophic sets and Neutrosophic numbers paves a way to handle uncertainty more effectively. In this paper we propose a new approach for ranking neutrosophic number by using its magnitude. We develop an algorithm for the solution of neutrosophic assignment problems involving pentagonal neutrosophic number. The proposed method is easy to understand and to apply for finding solution of neutrosophic assignment problems occurring in real life situations. To show the proposed strategy numerical models are given and the acquired results are analyzed.
    Schlagwörter neutrosophic sets ; neutrosophic number ; pentagonal neutrosophic number ; neutrosophic assignment problem ; optimal solution ; Mathematics ; QA1-939 ; Electronic computers. Computer science ; QA75.5-76.95
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag University of New Mexico
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Prevalence and causes of endemic hydric fluorosis in a village in rural Karnataka, India

    Arjunan Isaac / S Pruthvish / K Radhika / N S Murthy

    CHRISMED Journal of Health and Research, Vol 9, Iss 1, Pp 71-

    2022  Band 75

    Abstract: Background: Fluorosis is caused because of excessive fluoride intake. Karnataka is one among the states that have reported high fluoride content in the groundwater. This study aimed to determine the prevalence of and clinical manifestations suggestive of ...

    Abstract Background: Fluorosis is caused because of excessive fluoride intake. Karnataka is one among the states that have reported high fluoride content in the groundwater. This study aimed to determine the prevalence of and clinical manifestations suggestive of fluorosis, along with the causes for fluorosis among the population of Kaiwara village. Methodology: The present cross-sectional survey was performed among 3003 permanent residents of Kaiwara village. Demographic details such as age, occupation, education, economic status, and anthropometric details were recorded. Parameters such as predominant diet, genu valgum, and grades of goiter were studied and recorded to determine their association with fluorosis. Dean's index was used to detect dental fluorosis. The levels of fluoride in urine were estimated using the ELICO-LI-126 Fluoride ion analyzer. Results: The most observed age group among study subjects was 10–49 years (males: 813 and females: 1304). Age, diet, genu valgum, and grade of goiter were significantly (P < 0.001) associated with Dean's index. Of the study subjects, about 11.8% were unable to touch their toes indicating fluorosis. 2.075 mg/dl was the mean baseline fluoride level found in all the four samples from the main water tanks supplying water to the village. Out of 100 urine samples randomly taken, all had fluoride levels above the acceptable levels (>0.1 ppm). Conclusion: Hydric fluorosis is endemic among the general population of Kaiwara village in Karnataka. The main leading cause for fluorosis occurrence in this region might be due to high fluoride levels reported in the groundwater.
    Schlagwörter age groups ; dental ; genu valgum ; goiter ; urinalysis ; Medicine ; R ; Nursing ; RT1-120
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
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  3. Artikel: Validation of the Ayurvedic construct, Rasadhatudushti, in adults at risk of cardiovascular diseases - A mixed-method study.

    Rani R K, Radhika / Shajahan, M A

    Journal of Ayurveda and integrative medicine

    2022  Band 13, Heft 3, Seite(n) 100627

    Abstract: Background: Rasadhatudushti (RD), the deranged state of Rasadhatu, is a construct in Ayurveda mentioned as the cause of diseases affecting the circulatory channels and the heart, collectively called cardiovascular diseases (CVD). It is a morbid ... ...

    Abstract Background: Rasadhatudushti (RD), the deranged state of Rasadhatu, is a construct in Ayurveda mentioned as the cause of diseases affecting the circulatory channels and the heart, collectively called cardiovascular diseases (CVD). It is a morbid condition generic to some other disorders, hence is non-specific to CVD. It was observed that RD was present in majority of acute coronary artery disease in a cross-sectional, descriptive study in 250 patients stabilized after an acute episode.
    Objectives: To validate the available scale for assessing RD in the context of CVD risk. To study the prevalence of RD in participants at risk of cardiovascular diseases.
    Method: In the first part, validation of the scale for assessing RD, as mentioned in the texts, was done through standard steps for scale validation in the context of CVD risk. Psychometric analysis was done after administering the draft scale of 39 items in 218 participants above the age of 40 years who were not yet diagnosed with overt CVD conditions. Construct validation was done by comparing mean score of Framingham global risk score in high and low RD scores and comparing the reduction in CVD risk score assessed by Qrisk®2-2017 by life style modification and a conventional RD correction as add on. Second part was a cross sectional survey study to estimate the prevalence of RD in a specific population vulnerable to CVD. This was done in a sample of 160 sedentary government employees of Thiruvananthapuram District, Kerala, aged above 40, using the validated RD assessment scale.
    Result: -The final scale to assess RD, 'RAS-RCVD', with 25 symptoms was found to have concurrent validity using WHO/ISH risk prediction as the reference standard. Framingham global risk score also showed significant but low positive correlation with eight as the cut off for RD score. The reduction in mean (SD) Qrisk score was 2.53 (3.22) in the trial group receiving RD correction drug and 0.30 (3.43) in the control with statistical significance (p < 0.05). The prevalence of RD as assessed by RD score above the cut off in the second part of the study was 49.4%. The prevalence of RD was significantly high in participants with moderate to high risk for CVD (61.3%).
    Conclusion: - The construct RD was observed to be valid in pre-clinical states of CVD. There was a high prevalence of this morbid construct in moderate to high-risk individuals. Ayurvedic CVD prevention strategies need to target on correction of RD along with individual risk factor management.
    Sprache Englisch
    Erscheinungsdatum 2022-09-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 0975-9476
    ISSN 0975-9476
    DOI 10.1016/j.jaim.2022.100627
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: dsDNA-templated fluorescent copper nanoparticles for the detection of lipopolysaccharides

    N. K., Radhika / Gorthi, Sai Siva

    Analytical methods. 2021 Jan. 21, v. 13, no. 2

    2021  

    Abstract: The introduction of lipopolysaccharides (LPS) or endotoxins that originate from Gram-negative bacteria into the human blood stream induces a severe immune response that can lead to septic shock, and even death. Hence, the accurate detection of LPS is of ... ...

    Abstract The introduction of lipopolysaccharides (LPS) or endotoxins that originate from Gram-negative bacteria into the human blood stream induces a severe immune response that can lead to septic shock, and even death. Hence, the accurate detection of LPS is of great importance in the medical and pharmaceutical sectors. This paper proposes a novel label-free fluorescence assay for the detection of LPS utilizing aptamers and the interference synthesis of dsDNA-templated copper nanoparticles. The assay can be performed at room temperature and does not require expensive reagents. The proposed assay has a limit of detection of 0.95 ng ml⁻¹ of LPS, and the fluorescence emission from the copper nanoparticles was found to vary linearly with the concentration of LPS over a wide range (1 to 10⁵ ng ml⁻¹) with R² = 0.9877.
    Schlagwörter ambient temperature ; blood flow ; copper nanoparticles ; death ; detection limit ; endotoxins ; fluorescence ; humans ; immune response ; lipopolysaccharides ; oligonucleotides ; septic shock
    Sprache Englisch
    Erscheinungsverlauf 2021-0121
    Umfang p. 186-191.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d0ay01906b
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: dsDNA-templated fluorescent copper nanoparticles for the detection of lipopolysaccharides.

    N K, Radhika / Gorthi, Sai Siva

    Analytical methods : advancing methods and applications

    2020  Band 13, Heft 2, Seite(n) 186–191

    Abstract: The introduction of lipopolysaccharides (LPS) or endotoxins that originate from Gram-negative bacteria into the human blood stream induces a severe immune response that can lead to septic shock, and even death. Hence, the accurate detection of LPS is of ... ...

    Abstract The introduction of lipopolysaccharides (LPS) or endotoxins that originate from Gram-negative bacteria into the human blood stream induces a severe immune response that can lead to septic shock, and even death. Hence, the accurate detection of LPS is of great importance in the medical and pharmaceutical sectors. This paper proposes a novel label-free fluorescence assay for the detection of LPS utilizing aptamers and the interference synthesis of dsDNA-templated copper nanoparticles. The assay can be performed at room temperature and does not require expensive reagents. The proposed assay has a limit of detection of 0.95 ng ml-1 of LPS, and the fluorescence emission from the copper nanoparticles was found to vary linearly with the concentration of LPS over a wide range (1 to 105 ng ml-1) with R2 = 0.9877.
    Mesh-Begriff(e) Copper ; DNA ; Fluorescent Dyes ; Humans ; Lipopolysaccharides ; Metal Nanoparticles
    Chemische Substanzen Fluorescent Dyes ; Lipopolysaccharides ; Copper (789U1901C5) ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2020-12-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d0ay01906b
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: A rapid aptamer-based fluorescence assay for the detection of lipopolysaccharides using SYBR Green I.

    N K, Radhika / Kamali R, Vishaalini / Gorthi, Sai Siva

    Luminescence : the journal of biological and chemical luminescence

    2021  Band 36, Heft 7, Seite(n) 1632–1637

    Abstract: Lipopolysaccharides (endotoxins), found on Gram-negative bacteria, can trigger a severe immune response in humans leading to septic shock and in extreme cases, even death. Therefore, the detection and neutralization of lipopolysaccharides (LPS) is of ... ...

    Abstract Lipopolysaccharides (endotoxins), found on Gram-negative bacteria, can trigger a severe immune response in humans leading to septic shock and in extreme cases, even death. Therefore, the detection and neutralization of lipopolysaccharides (LPS) is of utmost importance in the pharmaceutical and medical industries. The United States Food and Drug Administration (US FDA) recommended detection method for LPS, the Limulus amebocyte lysate (LAL) assay, is expensive, time consuming, complex, and is prone to interference from proteases. As an alternative, this paper proposes a rapid, label-free fluorescence-based assay using LPS-specific aptamers and the SYBR Green DNA stain. The proposed method has a detection limit of 0.1 ng/ml, which is sufficient to detect the permissible levels of LPS in many pharmaceutical drugs and medical products. The fluorescence signal was found to be a linear function of the concentration of LPS in the range from 0.1 ng/ml to 10
    Mesh-Begriff(e) Benzothiazoles ; Biological Assay ; Diamines ; Endotoxins ; Humans ; Lipopolysaccharides ; Oligonucleotides ; Quinolines ; United States
    Chemische Substanzen Benzothiazoles ; Diamines ; Endotoxins ; Lipopolysaccharides ; Oligonucleotides ; Quinolines ; SYBR Green I (163795-75-3)
    Sprache Englisch
    Erscheinungsdatum 2021-07-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1470995-8
    ISSN 1522-7243 ; 1522-7235 ; 1099-1271
    ISSN (online) 1522-7243
    ISSN 1522-7235 ; 1099-1271
    DOI 10.1002/bio.4104
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Physicochemical basis of resistance in certain green gram genotypes to pulse bruchid, Calloso bruchus chinensis (L.)

    Kavitha G / Mahalakshmi MS / K. Bayyapu Reddy / Y. Pushpa Reni / K. Radhika

    Environment Conservation Journal, Vol 22, Iss

    2021  Band 3

    Abstract: A study was conducted to know the influence of physical and biochemical parameters on development of the pulse bruchid in green gram at RARS, Lam during 2017-18. The physical parameters of seed viz., colour, shape, surface texture, seed length and width, ...

    Abstract A study was conducted to know the influence of physical and biochemical parameters on development of the pulse bruchid in green gram at RARS, Lam during 2017-18. The physical parameters of seed viz., colour, shape, surface texture, seed length and width, seed coat hardness and 100 seed weight and biochemical parameters such as protein content, phenol content and total sugars were evaluated for twelve genotypes of greengram. The greengram genotypes with smooth texture, oblong or globose shape and light coloured seed might be less preferred by the pulse bruchid for egg laying. The data showed that genotypes having low sugar and protein contents and high phenol content were resistant to pulse bruchid. The correlation studies showed that biological parameters i.e., number of eggs, adult emergence and growth index had significant positive association with protein content, sugar content, moisture content and electrical conductivity and negative correlation phenol content, 100 seed weight and seed coat hardness. In contrast, mean development period had negative association with protein content, sugar content, electrical conductivity and moisture content and positive correlation with phenol content, 100 seed weight and seed coat hardness. Multiple linear regression studies revealed that all the physical and biochemical properties of seed together were contributing to a large and significant variation (65 to 87 %) in growth parameters of pulse bruchid.
    Schlagwörter Bruchid ; Greengram ; Phenols ; Proteins ; Seed coat thickness ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Action for Sustainable Efficacious Development and Awareness
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Enhancement of the fluorescence properties of double stranded DNA templated copper nanoparticles.

    N K, Radhika / Gorthi, Sai Siva

    Materials science & engineering. C, Materials for biological applications

    2019  Band 98, Seite(n) 1034–1042

    Abstract: The weak fluorescence emission from dsDNA templated copper nanoparticles necessitates the use of high-end detectors like photomultiplier tubes for their detection. This sets limitations on their applicability to in-situ analyte detection and point-of- ... ...

    Abstract The weak fluorescence emission from dsDNA templated copper nanoparticles necessitates the use of high-end detectors like photomultiplier tubes for their detection. This sets limitations on their applicability to in-situ analyte detection and point-of-care applications which utilize comparatively low cost and less sensitive detectors. In this article, a technique to improve the fluorescence properties of copper nanoparticles templated on dsDNA is reported. The fluorescence enhancement is achieved by introducing a modification in the conventional synthesis technique by using a combination of sodium ascorbate and Taq buffer. When compared to the existing methods, the proposed method achieves 11 times higher fluorescence signal intensity from the dsDNA templated copper nanoparticles and 4 times faster attainment of maximum fluorescence signal. The effect of the ionic strength of the individual constituent components of Taq buffer on the fluorescence emission from the copper nanoparticles is also studied here. The utility of this enhancement strategy for analyte measurement is demonstrated with the example of melamine detection from milk samples. A linear relationship was observed between the fluorescence intensity from the copper nanoparticles and the concentration of melamine in the range from 0.5 ppm to 100 ppm (R
    Mesh-Begriff(e) Copper/chemistry ; DNA/chemistry ; Fluorescence ; Fluorescent Dyes/chemistry ; Limit of Detection ; Metal Nanoparticles/chemistry ; Spectrometry, Fluorescence/methods
    Chemische Substanzen Fluorescent Dyes ; Copper (789U1901C5) ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2019-01-14
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2012160-X
    ISSN 1873-0191 ; 0928-4931
    ISSN (online) 1873-0191
    ISSN 0928-4931
    DOI 10.1016/j.msec.2019.01.042
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Migraine Disability, Quality of Life, and Its Predictors.

    R, Pradeep / S C, Nemichandra / S, Harsha / K, Radhika

    Annals of neurosciences

    2020  Band 27, Heft 1, Seite(n) 18–23

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2020-07-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2576191-2
    ISSN 0976-3260 ; 0972-7531
    ISSN (online) 0976-3260
    ISSN 0972-7531
    DOI 10.1177/0972753120929563
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  10. Artikel ; Online: A clinicopathologic study of malignant melanoma based on cytomorphology

    K Radhika / A K Prayaga / C Sundaram

    Indian Journal of Cancer, Vol 53, Iss 1, Pp 199-

    2016  Band 203

    Abstract: Context: Melanoma accounts for 1-3% of all malignancies. It is usually diagnosed as metastasis in the draining lymph nodes, that is inguinal lymph node. Due to paucity of cytological studies on melanoma in India, the present study was undertaken. AIM: To ...

    Abstract Context: Melanoma accounts for 1-3% of all malignancies. It is usually diagnosed as metastasis in the draining lymph nodes, that is inguinal lymph node. Due to paucity of cytological studies on melanoma in India, the present study was undertaken. AIM: To study the cytomorphology of malignant melanoma and to correlate the cytological diagnosis with histopathology and clinical details. Settings and Design: Sixteen cytomorphological features were studied and analysed from the cases diagnosed as melanoma on cytology with histopathological correlation. Materials and Methods: Thirty patients diagnosed with malignant melanoma on fine-needle aspiration cytology (FNAC) were studied over a period of 10 years and compared by histopathology. Papanicolaou (Pap)- and May Grunwald Giemsa (MGG)-stained smears were studied and analysed for the cytomorphological spectrum of melanoma. Results: Among the 30 patients studied, males were 19 and females were 11 (M:F:1.7:1) with a mean age of 49.3 years. The commonest primary site was foot followed by maxilla and thigh. The most common site for metastasis was inguinal lymph node. All 30 cases had histopathological correlation. Pigmented melanophages (83%) was the predominant feature followed by presence of melanin pigment (77%) and pseudo-inclusions (73%). Condensed chromatin was observed in the majority of the patients (53%). Smooth and irregular nuclear contours were seen in combination in 37% of the cases. A combination of nuclear placement, that is eccentric and central was observed as a predominant feature (53%). Spindle cell pattern was the predominant shape. Among cytoplasmic features, melanin granules and vacuoles were equally distributed (50%). Mixed pattern, that is singly scattered plasmacytoid cell pattern and cell clusters was the predominant cell architecture. Conclusion: A spectrum of cytomorphological features in correlation with clinical details leads to greater precision in diagnosis and helps to avoid pitfalls in diagnosing melanoma.
    Schlagwörter Cytomorphology ; fine-needle aspiration cytology ; melanoma ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
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