Article ; Online: Acute Kynurenine Exposure of Rat Thoracic Aorta Induces Vascular Dysfunction via Superoxide Anion Production.
Biological & pharmaceutical bulletin
2022 Volume 45, Issue 4, Page(s) 522–527
Abstract: The accumulation of uremic toxins is known to be one of the causes of cardiovascular disorder related to renal disease. Among the many uremic toxins, we focused on kynurenine (kyn), whose levels have been shown to be positively correlated with vascular ... ...
| Abstract | The accumulation of uremic toxins is known to be one of the causes of cardiovascular disorder related to renal disease. Among the many uremic toxins, we focused on kynurenine (kyn), whose levels have been shown to be positively correlated with vascular endothelial dysfunction markers, and directly evaluated the influence of kyn on the rat thoracic aorta. Exposure of the endothelium-intact aorta to kyn markedly attenuated the acetylcholine (ACh)-induced relaxation and significantly increased superoxide anion (O |
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| MeSH term(s) | Animals ; Aorta, Thoracic ; Endothelium, Vascular ; Kynurenine/pharmacology ; Rats ; Superoxides ; Vasodilation | |||||
| Chemical Substances | Superoxides (11062-77-4) ; Kynurenine (343-65-7) | |||||
| Language | English | |||||
| Publishing date | 2022-04-01 | |||||
| Publishing country | Japan | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1150271-x | |||||
| ISSN | 1347-5215 ; 0918-6158 | |||||
| ISSN (online) | 1347-5215 | |||||
| ISSN | 0918-6158 | |||||
| DOI | 10.1248/bpb.b21-01079 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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