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  1. Artikel ; Online: PET-CT for characterising TB infection (TBI) in immunocompetent subjects: a systematic review.

    Kim, Jee Whang / Munavvar, Rayhan / Kamil, Anver / Haldar, Pranabashis

    Journal of medical microbiology

    2023  Band 72, Heft 9

    Abstract: Introduction. ...

    Abstract Introduction.
    Mesh-Begriff(e) Animals ; Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Latent Tuberculosis ; Lymph Nodes
    Chemische Substanzen Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Sprache Englisch
    Erscheinungsdatum 2023-09-26
    Erscheinungsland England
    Dokumenttyp Systematic Review ; Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: PET-CT-guided characterisation of progressive, preclinical tuberculosis infection and its association with low-level circulating Mycobacterium tuberculosis DNA in household contacts in Leicester, UK: a prospective cohort study.

    Kim, Jee Whang / Bowman, Karen / Nazareth, Joshua / Lee, Joanne / Woltmann, Gerrit / Verma, Raman / Sharifpour, Meedya / Shield, Christopher / Rees, Catherine / Kamil, Anver / Swift, Benjamin / Haldar, Pranabashis

    The Lancet. Microbe

    2024  Band 5, Heft 2, Seite(n) e119–e130

    Abstract: Background: Incipient tuberculosis, a progressive state of Mycobacterium tuberculosis infection with an increased risk of developing into tuberculosis disease, remains poorly characterised. Animal models suggest an association of progressive infection ... ...

    Abstract Background: Incipient tuberculosis, a progressive state of Mycobacterium tuberculosis infection with an increased risk of developing into tuberculosis disease, remains poorly characterised. Animal models suggest an association of progressive infection with bacteraemia. Circulating M tuberculosis DNA has previously been detected in pulmonary tuberculosis by use of Actiphage, a bacteriophage-based real-time PCR assay. We aimed to investigate whether serial [
    Methods: We did a prospective 12-month cohort study in healthy, asymptomatic adults (aged ≥16 years) who were household contacts of patients with pulmonary tuberculosis, and who had a clinical phenotype of latent tuberculosis infection, in Leicester, UK. Actiphage testing of participants' blood samples was done at baseline, and [
    Findings: 20 contacts were recruited between Aug 5 and Nov 5, 2020; 16 of these participants had a positive result on IFNγ release assay (QuantiFERON-TB Gold Plus [QFT]) indicating tuberculosis infection. Baseline PET-CT scans were positive in ten contacts (all QFT positive), indeterminate in six contacts (three QFT positive), and negative in four contacts (three QFT positive). Four of eight PET-CT-positive contacts sampled had M tuberculosis identified (three through culture, one through Xpert MTB/RIF Ultra test) from intrathoracic lymph nodes or bronchial wash and received full antituberculosis treatment. Two further unsampled PET-CT-positive contacts were also treated: one with [
    Interpretation: Microbiological and inflammatory features of incipient tuberculosis can be visualised on PET-CT and are associated with M tuberculosis detection in the blood, supporting the development of pathogen-directed blood biomarkers of tuberculosis risk.
    Funding: MRC Confidence in Concept.
    Mesh-Begriff(e) Adult ; Humans ; Latent Tuberculosis/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Mycobacterium tuberculosis/genetics ; Prospective Studies ; Cohort Studies ; Fluorodeoxyglucose F18 ; Tuberculosis/diagnostic imaging ; Tuberculosis, Pulmonary/diagnostic imaging ; United Kingdom/epidemiology ; Antitubercular Agents
    Chemische Substanzen Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Antitubercular Agents
    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00289-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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