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  1. Artikel ; Online: Hypertension Increases Susceptibility to Experimental Malaria in Mice.

    Kandalgaonkar, Mrunmayee R / Yeoh, Beng San / Joe, Bina / Schmidt, Nathan W / Vijay-Kumar, Matam / Saha, Piu

    Function (Oxford, England)

    2024  Band 5, Heft 3, Seite(n) zqae009

    Abstract: Global prevalence of hypertension is on the rise, burdening healthcare, especially in developing countries where infectious diseases, such as malaria, are also rampant. Whether hypertension could predispose or increase susceptibility to malaria, however, ...

    Abstract Global prevalence of hypertension is on the rise, burdening healthcare, especially in developing countries where infectious diseases, such as malaria, are also rampant. Whether hypertension could predispose or increase susceptibility to malaria, however, has not been extensively explored. Previously, we reported that hypertension is associated with abnormal red blood cell (RBC) physiology and anemia. Since RBC are target host cells for malarial parasite,
    Mesh-Begriff(e) Animals ; Malaria/immunology ; Malaria/parasitology ; Malaria/complications ; Malaria/blood ; Malaria/physiopathology ; Plasmodium yoelii ; Mice ; Hypertension ; Erythrocytes/parasitology ; Erythrocytes/metabolism ; Disease Susceptibility ; Male ; Anemia/parasitology ; Disease Models, Animal ; Hemolysis
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqae009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy.

    Campbell, Connor / Kandalgaonkar, Mrunmayee R / Golonka, Rachel M / Yeoh, Beng San / Vijay-Kumar, Matam / Saha, Piu

    Biomedicines

    2023  Band 11, Heft 2

    Abstract: Gut microbes and their metabolites are actively involved in the development and regulation of host immunity, which can influence disease susceptibility. Herein, we review the most recent research advancements in the gut microbiota-immune axis. We discuss ...

    Abstract Gut microbes and their metabolites are actively involved in the development and regulation of host immunity, which can influence disease susceptibility. Herein, we review the most recent research advancements in the gut microbiota-immune axis. We discuss in detail how the gut microbiota is a tipping point for neonatal immune development as indicated by newly uncovered phenomenon, such as maternal imprinting, in utero intestinal metabolome, and weaning reaction. We describe how the gut microbiota shapes both innate and adaptive immunity with emphasis on the metabolites short-chain fatty acids and secondary bile acids. We also comprehensively delineate how disruption in the microbiota-immune axis results in immune-mediated diseases, such as gastrointestinal infections, inflammatory bowel diseases, cardiometabolic disorders (e.g., cardiovascular diseases, diabetes, and hypertension), autoimmunity (e.g., rheumatoid arthritis), hypersensitivity (e.g., asthma and allergies), psychological disorders (e.g., anxiety), and cancer (e.g., colorectal and hepatic). We further encompass the role of fecal microbiota transplantation, probiotics, prebiotics, and dietary polyphenols in reshaping the gut microbiota and their therapeutic potential. Continuing, we examine how the gut microbiota modulates immune therapies, including immune checkpoint inhibitors, JAK inhibitors, and anti-TNF therapies. We lastly mention the current challenges in metagenomics, germ-free models, and microbiota recapitulation to a achieve fundamental understanding for how gut microbiota regulates immunity. Altogether, this review proposes improving immunotherapy efficacy from the perspective of microbiome-targeted interventions.
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020294
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice.

    Yeoh, Beng San / Golonka, Rachel M / Saha, Piu / Kandalgaonkar, Mrunmayee R / Tian, Yuan / Osman, Islam / Patterson, Andrew D / Gewirtz, Andrew T / Joe, Bina / Vijay-Kumar, Matam

    Function (Oxford, England)

    2023  Band 4, Heft 5, Seite(n) zqad040

    Abstract: Sporadic occurrence of congenital portosystemic shunt (PSS) at a rate of ∼1 out of 10 among C57BL/6 J mice, which are widely used in biomedical research, results in aberrancies in serologic, metabolic, and physiologic parameters. Therefore, mice with PSS ...

    Abstract Sporadic occurrence of congenital portosystemic shunt (PSS) at a rate of ∼1 out of 10 among C57BL/6 J mice, which are widely used in biomedical research, results in aberrancies in serologic, metabolic, and physiologic parameters. Therefore, mice with PSS should be identified as outliers in research. Accordingly, we sought methods to, reliably and efficiently, identify PSS mice. Serum total bile acids ≥ 40 µm is a
    Mesh-Begriff(e) Animals ; Mice ; Portasystemic Shunt, Transjugular Intrahepatic ; Mice, Inbred C57BL ; Portal System/abnormalities ; Vascular Malformations ; Biomarkers
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-07-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqad040
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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