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  1. Artikel ; Online: Immune-inflammatory modulation by natural products derived from edible and medicinal herbs used in Chinese classical prescriptions.

    Kang, Qianming / He, Luying / Zhang, Yang / Zhong, Zhangfeng / Tan, Wen

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Band 130, Seite(n) 155684

    Abstract: Background: Edible and medicinal herbs: Purpose: Our purpose is to explore the potential therapeutic effect of EMHs with immune-inflammatory modulation for the study of modern cancer drugs.: Study design: In the present study, we present a ... ...

    Abstract Background: Edible and medicinal herbs
    Purpose: Our purpose is to explore the potential therapeutic effect of EMHs with immune-inflammatory modulation for the study of modern cancer drugs.
    Study design: In the present study, we present a detailed account of some EMHs used in CCPs that have shown considerable research potential in studies exploring modern drugs with immune-inflammatory modulation.
    Methods: Approximately 500 publications in the past 30 years were collected from PubMed, Web of Science and ScienceDirect using the keywords, such as natural products, edible and medicinal herbs, Chinese medicine, classical prescription, immune-inflammatory, tumor microenvironment and some related synonyms. The active ingredients instead of herbal extracts or botanical mixtures were focused on and the research conducted over the past decade were discussed emphatically and analyzed comprehensively.
    Results: More than ten natural products derived from EMHs used in CCPs are discussed and their immune-inflammatory modulation activities, including enhancing antitumor immunity, regulating inflammatory signaling pathways, lowering the proportion of immunosuppressive cells, inhibiting the secretion of proinflammatory cytokines, immunosuppressive factors, and inflammatory mediators, are summarized.
    Conclusion: Our findings demonstrate the immune-inflammatory modulating role of those EMHs used in CCPs and provide new ideas for cancer treatment in clinical settings.
    Sprache Englisch
    Erscheinungsdatum 2024-05-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer.

    He, Luying / Kang, Qianming / Chan, Ka Iong / Zhang, Yang / Zhong, Zhangfeng / Tan, Wen

    Frontiers in immunology

    2023  Band 13, Seite(n) 1093990

    Abstract: Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that function through the extracellular matrix (ECM). They are involved in diverse pathophysiological processes, such as tumor invasion and metastasis, cardiovascular diseases, ...

    Abstract Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that function through the extracellular matrix (ECM). They are involved in diverse pathophysiological processes, such as tumor invasion and metastasis, cardiovascular diseases, arthritis, periodontal disease, osteogenesis imperfecta, and diseases of the central nervous system. MMPs participate in the occurrence and development of numerous cancers and are closely related to immunity. In the present study, we review the immunomodulatory role of MMPs in colitis-associated cancer (CAC) and discuss relevant clinical applications. We analyze more than 300 pharmacological studies retrieved from PubMed and the Web of Science, related to MMPs, cancer, colitis, CAC, and immunomodulation. Key MMPs that interfere with pathological processes in CAC such as MMP-2, MMP-3, MMP-7, MMP-9, MMP-10, MMP-12, and MMP-13, as well as their corresponding mechanisms are elaborated. MMPs are involved in cell proliferation, cell differentiation, angiogenesis, ECM remodeling, and the inflammatory response in CAC. They also affect the immune system by modulating differentiation and immune activity of immune cells, recruitment of macrophages, and recruitment of neutrophils. Herein we describe the immunomodulatory role of MMPs in CAC to facilitate treatment of this special type of colon cancer, which is preceded by detectable inflammatory bowel disease in clinical populations.
    Mesh-Begriff(e) Humans ; Cardiovascular Diseases/metabolism ; Colitis/metabolism ; Colitis-Associated Neoplasms/metabolism ; Extracellular Matrix/metabolism ; Neoplasms/metabolism ; Matrix Metalloproteinases/metabolism
    Chemische Substanzen Matrix Metalloproteinases (EC 3.4.24.-)
    Sprache Englisch
    Erscheinungsdatum 2023-01-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1093990
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

    He, Luying / Kang, Qianming / Zhang, Yang / Chen, Man / Wang, Zefei / Wu, Yonghui / Gao, Hetong / Zhong, Zhangfeng / Tan, Wen

    Phytotherapy Research. 2023 July, v. 37, no. 7 p.3135-3160

    2023  

    Abstract: Glycyrrhizae Radix et Rhizoma is a well‐known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. ... ...

    Abstract Glycyrrhizae Radix et Rhizoma is a well‐known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. The article discusses the resources and distribution of species, methods of authentication and determination chemical composition, quality control of the original plants and herbal medicines, dosages use, common classical prescriptions, indications, and relevant mechanisms of the active content. Pharmacokinetic parameters, toxicity tests, clinical trials, and patent applications are discussed. The review will provide a good starting point for the research and development of classical prescriptions to develop herbal medicines for clinical use.
    Schlagwörter chemical composition ; herbal medicines ; pharmacokinetics ; phytotherapy ; quality control ; research and development ; toxicity
    Sprache Englisch
    Erscheinungsverlauf 2023-07
    Umfang p. 3135-3160.
    Erscheinungsort John Wiley & Sons, Ltd.
    Dokumenttyp Artikel ; Online
    Anmerkung REVIEW
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7869
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

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  4. Artikel ; Online: Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions.

    He, Luying / Kang, Qianming / Zhang, Yang / Chen, Man / Wang, Zefei / Wu, Yonghui / Gao, Hetong / Zhong, Zhangfeng / Tan, Wen

    Phytotherapy research : PTR

    2023  Band 37, Heft 7, Seite(n) 3135–3160

    Abstract: Glycyrrhizae Radix et Rhizoma is a well-known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. ... ...

    Abstract Glycyrrhizae Radix et Rhizoma is a well-known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. The article discusses the resources and distribution of species, methods of authentication and determination chemical composition, quality control of the original plants and herbal medicines, dosages use, common classical prescriptions, indications, and relevant mechanisms of the active content. Pharmacokinetic parameters, toxicity tests, clinical trials, and patent applications are discussed. The review will provide a good starting point for the research and development of classical prescriptions to develop herbal medicines for clinical use.
    Mesh-Begriff(e) Medicine, Chinese Traditional ; Herbal Medicine ; Drugs, Chinese Herbal/therapeutic use ; Plants, Medicinal ; Prescriptions
    Chemische Substanzen glycyrrhizae radix et rhizoma (2788Z9758H) ; Drugs, Chinese Herbal
    Sprache Englisch
    Erscheinungsdatum 2023-05-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7869
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

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