Artikel ; Online: It is not NOD2 - genetic and clinical risk factors for postoperative complications following ileocolic resection in Crohn's disease.
International journal of colorectal disease
2022 Band 37, Heft 8, Seite(n) 1901–1908
Abstract: Purpose: To evaluate the role of the nucleotide oligomerization domain 2 (NOD2) mutation status and other risk factors for the incidence of postoperative complications after ileocolic resection for Crohn's disease (CD).: Methods: Data of 138 patients ...
Abstract | Purpose: To evaluate the role of the nucleotide oligomerization domain 2 (NOD2) mutation status and other risk factors for the incidence of postoperative complications after ileocolic resection for Crohn's disease (CD). Methods: Data of 138 patients consecutively undergoing ileocolic resection for CD at a tertiary academic referral center were retrospectively analyzed including single nucleotide polymorphism (SNP) data of the NOD2 gene. Uni- and multivariate regression analysis was performed to identify factors associated with increased risk of severe postoperative complications. Results: From 114 patients (83%), the NOD2 mutation status was available. Of these, 60 (53%) had a NOD2 wildtype, whereas eleven (10%) were homozygous for the high risk p.Leu1007fsX1008 (rs2066847) variant. Major postoperative complications occurred in 28 patients (20%). Twenty-seven of these (96%) were intraabdominal septic complications such as anastomotic leakage or abscess. Male gender (P = 0.029; OR 3.052, the duration of CD (time [months] from initial diagnosis of CD to surgery; P = 0.001; OR 1.009), previous abdominal surgery for CD (P = 0.017; OR 3.49), and the presence of enteric fistulas (P = 0.023; OR 3.21) were identified as independent risk factors for major postoperative complications. Homozygosity for the NOD2 high-risk variant p.Leu1007fsX1008 did not show increased postoperative morbidity in the short and long-term outcome. Conclusions: We could detect independent risk factors for major postoperative complications after ileocolic resection for Crohn's disease. However, patients with the high-risk variant p.Leu1007fsX1008 of the NOD2 gene did not show increased postoperative morbidity. |
|||||
---|---|---|---|---|---|---|
Mesh-Begriff(e) | Crohn Disease/complications ; Crohn Disease/genetics ; Crohn Disease/surgery ; Humans ; Male ; Nod2 Signaling Adaptor Protein/genetics ; Nucleotides ; Postoperative Complications/genetics ; Retrospective Studies ; Risk Factors | |||||
Chemische Substanzen | Nod2 Signaling Adaptor Protein ; Nucleotides | |||||
Sprache | Englisch | |||||
Erscheinungsdatum | 2022-08-01 | |||||
Erscheinungsland | Germany | |||||
Dokumenttyp | Journal Article | |||||
ZDB-ID | 84975-3 | |||||
ISSN | 1432-1262 ; 0179-1958 | |||||
ISSN (online) | 1432-1262 | |||||
ISSN | 0179-1958 | |||||
DOI | 10.1007/s00384-022-04223-6 | |||||
Signatur |
|
|||||
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 2121: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.