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  1. Artikel ; Online: Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic.

    Hallam, T M / Sharp, S J / Andreadi, A / Kavanagh, D

    Immunobiology

    2023  Band 228, Heft 5, Seite(n) 152410

    Abstract: Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate ... ...

    Abstract Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate whereupon a structural reorganization allows the catalytic triad to cleave its substrates, C3b and C4b. In keeping with its role as the master complement regulatory enzyme, deficiency has been linked to immunopathology. In the setting of complete FI deficiency, a consumptive C3 deficiency results in recurrent infections with encapsulated microorganisms. Aseptic cerebral inflammation and vasculitic presentations are also less commonly observed. Heterozygous mutations in the factor I gene (CFI) have been demonstrated to be enriched in atypical haemolytic uraemic syndrome, albeit with a very low penetrance. Haploinsufficiency of CFI has also been associated with decreased retinal thickness and is a strong risk factor for the development of age-related macular degeneration. Supplementation of FI using plasma purified or recombinant protein has long been postulated, however, technical difficulties prevented progression into clinical trials. It is only using gene therapy that CFI supplementation has reached the clinic with GT005 in phase I/II clinical trials for geographic atrophy.
    Mesh-Begriff(e) Humans ; Complement Factor I/chemistry ; Complement C3/genetics ; Atypical Hemolytic Uremic Syndrome ; Mutation ; Inflammation ; Complement C3b
    Chemische Substanzen Complement Factor I (EC 3.4.21.45) ; Complement C3 ; Complement C3b (80295-43-8)
    Sprache Englisch
    Erscheinungsdatum 2023-06-05
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2023.152410
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Transferability of Technical Skills Across Robotic Surgery Platforms: A Scoping Review.

    Devine, Michael / Morris, Marie / Kavanagh, Dara

    Cureus

    2024  Band 16, Heft 3, Seite(n) e56429

    Abstract: As the application of robotic approaches to surgery continues to broaden, new consoles have been introduced to the market. Due to the global utilization of a single platform, previously validated curricula have not been assessed on new robotic systems. ... ...

    Abstract As the application of robotic approaches to surgery continues to broaden, new consoles have been introduced to the market. Due to the global utilization of a single platform, previously validated curricula have not been assessed on new robotic systems. Surgery by its nature occurs in a high-stakes environment, potentially exacerbated by non-standardized robotic systems. The aim of this review is to critique the evidence available regarding the transferability of technical skills across robotic platforms. A scoping review utilizing the Medline (Pubmed) and Cochrane Databases was conducted. Full texts were reviewed and appraised. Selected articles were eligible for inclusion if they investigated the ability or implications of the transfer of skill across robotic platforms. Data was extracted, coded inductively, and themes synthesized. NVIVO software was used as an adjunct for this qualitative analysis. Following the removal of duplicates a total of 278 papers were screened according to the eligibility criteria. Fifty full-text articles were reviewed and four met the criterion for inclusion. Novices' performance across platforms was comparable. Increasing levels of prior robotic experience revealed an improvement in technical performance on a novel robotic platform. Safety metrics appear comparable across systems. Quantifying learning curves across robotic platforms and their implications for the robotic surgeon in training remains to be determined. Future research needs to address the gaps in the literature by clearly defining the extent of technical skills transfer between robotic platforms. These factors will guide the next iteration of surgical training curriculums and regulations for robotic surgery.
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56429
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch ; Online: Chief Dental Officer letter to registrants, 20/03/2020

    Kavanagh, Dympna

    2020  

    Schlagwörter Covid-19 ; Coronavirus ; Dentists ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-03-20
    Verlag Health Protection Surveillance Centre
    Erscheinungsland ie
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Diagnosis and treatment of thrombotic microangiopathy.

    Thompson, Gemma L / Kavanagh, David

    International journal of laboratory hematology

    2022  Band 44 Suppl 1, Seite(n) 101–113

    Abstract: Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal ... ...

    Abstract Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal involvement is common as the kidney is particularly susceptible to the endothelial damage and microvascular occlusion. TMAs require rapid assessment, diagnosis, and commencement of appropriate treatment due to the high morbidity and mortality associated with them. Ground-breaking research into the pathogenesis of TMAs over the past 20 years has driven the successful development of targeted therapeutics revolutionizing patient outcomes. This review outlines the clinical presentations, pathogenesis, diagnostic tests and treatments for TMAs.
    Mesh-Begriff(e) Humans ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/therapy
    Sprache Englisch
    Erscheinungsdatum 2022-09-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13954
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: XXIX International Complement Workshop Newcastle 2023.

    Marchbank, Kevin J / Kavanagh, David / Harris, Claire L

    Immunobiology

    2023  Band 228, Heft 5, Seite(n) 152729

    Sprache Englisch
    Erscheinungsdatum 2023-08-10
    Erscheinungsland Netherlands
    Dokumenttyp Editorial
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2023.152729
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  6. Artikel ; Online: Use of a B-cell depleting regimen for antifactor H autoantibody-mediated membranoproliferative glomerulonephritis in a paediatric patient.

    Henderson, Sarah / Ardill, Rosalyn / Reynolds, Ben / Kavanagh, David

    BMJ case reports

    2022  Band 15, Heft 4

    Abstract: A male child presented initially well with a mixed nephrotic-nephritic syndrome and was commenced on standard high-dose oral corticosteroids. Clinical deterioration occurred 3 weeks later with rapidly progressing renal dysfunction, seizures and ... ...

    Abstract A male child presented initially well with a mixed nephrotic-nephritic syndrome and was commenced on standard high-dose oral corticosteroids. Clinical deterioration occurred 3 weeks later with rapidly progressing renal dysfunction, seizures and diminished urinary output, requiring renal replacement therapy. Once stabilised, renal biopsy demonstrated mesangial and capillary C3, minimal IgG deposition, with mesangial electron dense deposits felt consistent with postinfectious glomerulonephritis or C3 glomerulopathy. Further investigations identified circulating autoantibody directed against factor H, as a plausible aetiology of the membranoproliferative glomerulonephritis (MPGN). Treatment with rituximab and mycophenolate mofetil was associated with a reduction in antibody titres and a concurrent reduction in proteinuria and normalisation of renal function.Subsequent monitoring of antibody titres prompted further administrations of rituximab, with reduction in titres demonstrated after repeat doses. Atypical presentations or complications of nephrotic syndrome or MPGN should prompt detailed investigations for the cause with consideration of antifactor H antibodies.
    Mesh-Begriff(e) Autoantibodies ; Child ; Female ; Glomerulonephritis/drug therapy ; Glomerulonephritis/etiology ; Glomerulonephritis, Membranoproliferative/pathology ; Humans ; Male ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/etiology ; Rituximab/therapeutic use
    Chemische Substanzen Autoantibodies ; Rituximab (4F4X42SYQ6)
    Sprache Englisch
    Erscheinungsdatum 2022-04-20
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-246281
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Policy planner. Interview by Paul O'Grady.

    Kavanagh, Dympna

    Journal of the Irish Dental Association

    2014  Band 60, Heft 2, Seite(n) 82–83

    Mesh-Begriff(e) Dental Care ; Dentists/supply & distribution ; Health Planning ; Health Policy ; Health Priorities ; Health Services Needs and Demand ; Humans ; Ireland ; Oral Health ; State Dentistry/organization & administration
    Sprache Englisch
    Erscheinungsdatum 2014-04
    Erscheinungsland Ireland
    Dokumenttyp Interview
    ZDB-ID 603659-4
    ISSN 0021-1133
    ISSN 0021-1133
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Validation of deep learning-based markerless 3D pose estimation.

    Kosourikhina, Veronika / Kavanagh, Diarmuid / Richardson, Michael J / Kaplan, David M

    PloS one

    2022  Band 17, Heft 10, Seite(n) e0276258

    Abstract: Deep learning-based approaches to markerless 3D pose estimation are being adopted by researchers in psychology and neuroscience at an unprecedented rate. Yet many of these tools remain unvalidated. Here, we report on the validation of one increasingly ... ...

    Abstract Deep learning-based approaches to markerless 3D pose estimation are being adopted by researchers in psychology and neuroscience at an unprecedented rate. Yet many of these tools remain unvalidated. Here, we report on the validation of one increasingly popular tool (DeepLabCut) against simultaneous measurements obtained from a reference measurement system (Fastrak) with well-known performance characteristics. Our results confirm close (mm range) agreement between the two, indicating that under specific circumstances deep learning-based approaches can match more traditional motion tracking methods. Although more work needs to be done to determine their specific performance characteristics and limitations, this study should help build confidence within the research community using these new tools.
    Mesh-Begriff(e) Deep Learning ; Motion
    Sprache Englisch
    Erscheinungsdatum 2022-10-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0276258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A Pragmatic Informatics Approach to Develop Knowledge Tools for Supporting Cardiac Surgical Patients' Mental Health Needs.

    Smith, Susan / Strodl, Esben / Varnfield, Marlien / Kavanagh, David / Rolls, Tricia / Gurunathan, Usha / Janoschka, Bo / Naidoo, Rishendran

    Studies in health technology and informatics

    2024  Band 310, Seite(n) 1410–1411

    Abstract: A pragmatic informatics approach was developed to create knowledge tools for co-design of a new model of mental healthcare in cardiac surgery The real-world evidence generation leverages existing technological platforms and routine data collections plus ... ...

    Abstract A pragmatic informatics approach was developed to create knowledge tools for co-design of a new model of mental healthcare in cardiac surgery The real-world evidence generation leverages existing technological platforms and routine data collections plus tailored brief tools, surveys and qualitative data.
    Mesh-Begriff(e) Humans ; Mental Health ; Cardiac Surgical Procedures ; Heart ; Patients ; Informatics
    Sprache Englisch
    Erscheinungsdatum 2024-01-25
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI231219
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  10. Artikel: Characterizing individual trainee learning curves in surgical training: Challenges and opportunities.

    Toale, C / O'Byrne, A / Morris, M / Kavanagh, D O

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2022  Band 21, Heft 5, Seite(n) 285–288

    Abstract: The surgical learning curve is an observable and measurable phenomenon. In the era of competency-based approaches to surgical training, monitoring the trajectory of individual trainee competence attainment could represent a meaningful method of formative ...

    Abstract The surgical learning curve is an observable and measurable phenomenon. In the era of competency-based approaches to surgical training, monitoring the trajectory of individual trainee competence attainment could represent a meaningful method of formative and summative assessment. While technology can assist this approach, a number of significant barriers to the implementation of such assessment methods remain, including: accurate data collection, standard setting, and reliable assessment. Translating individual learning curve data into quantifiable case minimum targets in training poses further difficulties, and may not be possible for all procedures, particularly those that are less frequently performed and assessed. In spite of these challenges, significant benefits could be realized through an individualized approach to competency assessment using trainee learning curve data. Tracking competence acquisition against criterion-referenced standards could allow for targeted training and remediation, conforming with modern theories of adult education and empowering trainees to take control of their own learning. Learning curve data could also be used to assess the effects of educational interventions such as simulation-based training on subsequent competence acquisition rates. Ultimately, the individual learning curves of trainees could be used to inform personalised decisions regarding entrustment, credentialing, and certification, allowing training programmes to move beyond minimum operative experience targets as a crude proxy measure of competence.
    Mesh-Begriff(e) Adult ; Humans ; Learning Curve ; Clinical Competence
    Sprache Englisch
    Erscheinungsdatum 2022-11-26
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2022.11.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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