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  1. Artikel ; Online: Atypical Chest Computed Tomography Finding of Predominant Interstitial Thickening in a Patient with Coronavirus Disease 2019 (COVID-19) Pneumonia.

    Lau, Jaclyn Yee Cheun / Khoo, Hau Wei / Hui, Terrence Chi Hong / Kaw, Gregory Jon Leng / Tan, Cher Heng

    The American journal of case reports

    2020  Band 21, Seite(n) e926781

    Abstract: BACKGROUND Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, SARS-CoV-2, and is associated with severe respiratory disease. There are extensive publications on the chest computed tomography (CT) findings of COVID-19 pneumonia, with ... ...

    Abstract BACKGROUND Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, SARS-CoV-2, and is associated with severe respiratory disease. There are extensive publications on the chest computed tomography (CT) findings of COVID-19 pneumonia, with ground-glass opacities (GGO) and mixed GGO and consolidation being the most common findings. Those with interstitial thickening manifesting as reticular opacities typically show superimposed ground-glass opacities, giving a crazy-paving pattern. CASE REPORT We report the case of a 77-year-old man with a background of asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) who presented with progressive cough and shortness of breath for 2 days. He was in close contact with a confirmed COVID-19 case. Reverse-transcription polymerase chain reaction analysis of a nasopharyngeal swab was positive for SARS-CoV-2. The initial chest radiograph was negative for lung consolidation and ground-glass opacities. During admission, he had worsening shortness of breath with desaturation, prompting a chest CT examination, which was performed on day 14 of illness. The chest CT revealed an atypical finding of predominant focal subpleural interstitial thickening in the right lower lobe. He was provided supportive treatment along with steroid and antibiotics. He recovered well and subsequently tested negative for 2 consecutive swabs. He was discharged after 34 days. CONCLUSIONS Interstitial thickening or reticular pattern on CT has been described in COVID-19 pneumonia, but largely in association with ground-glass opacity or consolidation. This case demonstrates an atypical predominance of interstitial thickening on chest CT in COVID-19 pneumonia on day 14 of illness, which is the expected time of greatest severity of the disease.
    Mesh-Begriff(e) Adrenal Cortex Hormones/administration & dosage ; Aged ; Anti-Bacterial Agents/administration & dosage ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Contrast Media ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Cough/diagnosis ; Cough/etiology ; Disease Progression ; Dyspnea/diagnosis ; Dyspnea/etiology ; Follow-Up Studies ; Humans ; Intensive Care Units ; Length of Stay ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/therapy ; Male ; Multidetector Computed Tomography/methods ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/diagnostic imaging ; Radiographic Image Enhancement ; Risk Assessment ; Severe Acute Respiratory Syndrome/diagnostic imaging ; Severe Acute Respiratory Syndrome/virology ; Treatment Outcome
    Chemische Substanzen Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Contrast Media
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-21
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.926781
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Variable computed tomography appearances of COVID-19.

    Lim, Zhan Ye / Khoo, Hau Wei / Hui, Terrence Chi Hong / Kok, Shawn Shi Xian / Kwan, Kenneth Eng Ling / Young, Barnaby Edward / Tan, Cher Heng / Kaw, Gregory Jon Leng

    Singapore medical journal

    2020  Band 61, Heft 7, Seite(n) 387–391

    Abstract: The coronavirus disease 2019 (COVID-19) is typically diagnosed by specific assays that detect viral nucleic acid from the upper respiratory tract; however, this may miss infections involving only the lower airways. Computed tomography (CT) has been ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is typically diagnosed by specific assays that detect viral nucleic acid from the upper respiratory tract; however, this may miss infections involving only the lower airways. Computed tomography (CT) has been described as a diagnostic modality in the COVID-19 diagnosis and treatment plan. We present a case series with virologically confirmed COVID-19 pneumonia. Variable CT features were observed: consolidation with ground-glass opacities, ground-glass opacities with subpleural reticular bands, and an anterior-posterior gradient of lung abnormalities resembling that of acute respiratory distress syndrome. Evolution of CT findings was observed in one patient, where there was interval resolution of bilateral lung consolidation with development of bronchiolectasis and subpleural fibrotic bands. While sensitive for detecting lung parenchymal abnormalities in COVID-19 pneumonia, the use of CT for initial diagnosis is discouraged and should be reserved for specific clinical indications. Interpretation of chest CT findings should be correlated with duration of symptoms to better determine the disease stage and aid in patient management.
    Mesh-Begriff(e) Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-21
    Erscheinungsland India
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.11622/smedj.2020066
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Variable computed tomography appearances of COVID-19

    Lim, Zhan Ye / Khoo, Hau Wei / Hui, Terrence Chi Hong / Kok, Shawn Shi Xian / Kwan, Kenneth Eng Ling / Young, Barnaby Edward / Tan, Cher Heng / Kaw, Gregory Jon Leng

    Singapore Med J

    Abstract: The coronavirus disease 2019 (COVID-19) is typically diagnosed by specific assays that detect viral nucleic acid from the upper respiratory tract; however, this may miss infections involving only the lower airways. Computed tomography (CT) has been ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is typically diagnosed by specific assays that detect viral nucleic acid from the upper respiratory tract; however, this may miss infections involving only the lower airways. Computed tomography (CT) has been described as a diagnostic modality in the COVID-19 diagnosis and treatment plan. We present a case series with virologically confirmed COVID-19 pneumonia. Variable CT features were observed: consolidation with ground-glass opacities, ground-glass opacities with subpleural reticular bands, and an anterior-posterior gradient of lung abnormalities resembling that of acute respiratory distress syndrome. Evolution of CT findings was observed in one patient, where there was interval resolution of bilateral lung consolidation with development of bronchiolectasis and subpleural fibrotic bands. While sensitive for detecting lung parenchymal abnormalities in COVID-19 pneumonia, the use of CT for initial diagnosis is discouraged and should be reserved for specific clinical indications. Interpretation of chest CT findings should be correlated with duration of symptoms to better determine the disease stage and aid in patient management.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #95004
    Datenquelle COVID19

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  4. Artikel: Radiographic features of COVID-19 based on an initial cohort of 96 patients in Singapore.

    Khoo, Hau Wei Wei / Hui, Terrence Chi Hong / Mohideen, Salahudeen Mohamed Haja / Lee, Yeong Shyan / Liew, Charlene Jin Yee / Kok, Shawn Shi Xian / Young, Barnaby Edward / Ong, Sean Wei Xiang / Kalimuddin, Shirin / Tan, Seow Yen / Loh, Jiashen / Chan, Lai Peng / Poh, Angeline Choo Choo / Wong, Steven Bak Siew / Leo, Yee-Sin / Lye, David Chien / Kaw, Gregory Jon Leng / Tan, Cher Heng

    Singapore medical journal

    2020  Band 62, Heft 9, Seite(n) 458–465

    Abstract: Introduction: Chest radiographs (CXRs) are widely used for the screening and management of COVID-19. This article describes the radiographic features of COVID-19 based on an initial national cohort of patients.: Methods: This is a retrospective ... ...

    Abstract Introduction: Chest radiographs (CXRs) are widely used for the screening and management of COVID-19. This article describes the radiographic features of COVID-19 based on an initial national cohort of patients.
    Methods: This is a retrospective review of swab-positive patients with COVID-19 who were admitted to four different hospitals in Singapore between 22 January and 9 March 2020. Initial and follow-up CXRs were reviewed by three experienced radiologists to identify the predominant pattern and distribution of lung parenchymal abnormalities.
    Results: In total, 347 CXRs of 96 patients were reviewed. Initial CXRs were abnormal in 41 (42.7%) out of 96 patients. The mean time from onset of symptoms to CXR abnormality was 5.3 ± 4.7 days. The predominant pattern of lung abnormality was ground-glass opacity on initial CXRs (51.2%) and consolidation on follow-up CXRs (51.0%). Multifocal bilateral abnormalities in mixed central and peripheral distribution were observed in 63.4% and 59.2% of abnormal initial and follow-up CXRs, respectively. The lower zones were involved in 90.2% of initial CXRs and 93.9% of follow-up CXRs.
    Conclusion: In a cohort of swab-positive patients, including those identified from contact tracing, we found a lower incidence of CXR abnormalities than was previously reported. The most common pattern was ground-glass opacity or consolidation, but mixed central and peripheral involvement was more common than peripheral involvement alone.
    Mesh-Begriff(e) COVID-19 ; Humans ; Lung/diagnostic imaging ; Radiography, Thoracic ; Retrospective Studies ; SARS-CoV-2 ; Singapore
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-21
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2020142
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: A practical and adaptive approach to lung cancer screening: a review of international evidence and position on CT lung cancer screening in the Singaporean population by the College of Radiologists Singapore.

    Liew, Charlene Jin Yee / Leong, Lester Chee Hao / Teo, Lynette Li San / Ong, Ching Ching / Cheah, Foong Koon / Tham, Wei Ping / Salahudeen, Haja Mohamed Mohideen / Lee, Chau Hung / Kaw, Gregory Jon Leng / Tee, Augustine Kim Huat / Tsou, Ian Yu Yan / Tay, Kiang Hiong / Quah, Raymond / Tan, Bien Peng / Chou, Hong / Tan, Daniel / Poh, Angeline Choo Choo / Tan, Andrew Gee Seng

    Singapore medical journal

    2019  Band 60, Heft 11, Seite(n) 554–559

    Abstract: Lung cancer is the leading cause of cancer-related death around the world, being the top cause of cancer-related deaths among men and the second most common cause of cancer-related deaths among women in Singapore. Currently, no screening programme for ... ...

    Abstract Lung cancer is the leading cause of cancer-related death around the world, being the top cause of cancer-related deaths among men and the second most common cause of cancer-related deaths among women in Singapore. Currently, no screening programme for lung cancer exists in Singapore. Since there is mounting evidence indicating a different epidemiology of lung cancer in Asian countries, including Singapore, compared to the rest of the world, a unique and adaptive approach must be taken for a screening programme to be successful at reducing mortality while maintaining cost-effectiveness and a favourable risk-benefit ratio. This review article promotes the use of low-dose computed tomography of the chest and explores the radiological challenges and future directions.
    Mesh-Begriff(e) Algorithms ; Clinical Trials as Topic ; Cost-Benefit Analysis ; Deep Learning ; Diagnosis, Computer-Assisted ; Early Detection of Cancer/methods ; Europe ; False Positive Reactions ; Humans ; Interdisciplinary Communication ; Lung Neoplasms/diagnostic imaging ; Mass Screening/methods ; Practice Guidelines as Topic ; Public Health ; Radiation Dosage ; Radiology/organization & administration ; Registries ; Risk Assessment ; Singapore/epidemiology ; Smoking Cessation ; Tomography, X-Ray Computed/methods ; United States
    Sprache Englisch
    Erscheinungsdatum 2019-12-19
    Erscheinungsland Singapore
    Dokumenttyp Journal Article ; Review
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2019145
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Radiographic features of COVID-19 based on an initial cohort of 96 patients in Singapore

    Khoo, Hau Wei / Hui, Terrence Chi Hong / Haja Mohideen, Salahudeen Mohamed / Lee, Yeong Shyan / Liew, Charlene Jin Yee / Kok, Shawn Shi Xian / Young, Barnaby Edward / Ong, Sean Wei Xiang / Kalimuddin, Shirin / Tan, Seow Yen / Loh, Jiashen / Chan, Lai Peng / Poh, Angeline Choo Choo / Wong, Steven Bak Siew / Leo, Yee-Sin / Lye, David Chien / Kaw, Gregory Jon Leng / Tan, Cher Heng

    Singap. med. j

    Abstract: INTRODUCTION: Chest radiographs (CXR) are widely used for the screening and management of the coronavirus disease 2019 (COVID-19). This paper determinates the radiographic features of COVID-19 based on an initial national cohort of patients. METHODS: ... ...

    Abstract INTRODUCTION: Chest radiographs (CXR) are widely used for the screening and management of the coronavirus disease 2019 (COVID-19). This paper determinates the radiographic features of COVID-19 based on an initial national cohort of patients. METHODS: This is a retrospective review of swab-positive COVID-19 patients admitted to four different hospitals in Singapore between 22 January and 9 March 2020. Initial and follow-up CXR were reviewed by three experienced radiologists to identify the predominant pattern and distribution of lung parenchymal abnormalities. RESULTS: In total, 347 CXR of 96 patients were reviewed. Initial CXR were abnormal in 41 out of 96 patients (42.7%). The mean time from onset of symptoms to CXR abnormality was 5.3 (range 1-21) days. The predominant pattern of lung abnormality was ground-glass opacity on initial CXR (51.2%) and consolidation on follow-up CXR (51.0%). Multifocal bilateral abnormalities in mixed central and peripheral distribution were seen in 63.4% and 59.2% of abnormal initial and follow-up CXR, respectively. The lower zones were involved in 90.2% of the initial CXR and 93.9% of the follow-up CXR. CONCLUSION: In a cohort of swab-positive patients, including those identified from contact tracing, we found the incidence of CXR abnormality to be lower than previously reported. The most common pattern was ground-glass opacity or consolidation, but mixed central and peripheral involvement was more common than peripheral involvement alone.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #854647
    Datenquelle COVID19

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  7. Artikel: Ministry of Health Clinical Practice Guidelines: Prevention, Diagnosis and Management of Tuberculosis.

    Wang, Yee Tang Sonny / Chee, Cynthia Bin Eng / Hsu, Li Yang / Jagadesan, Raghuram / Kaw, Gregory Jon Leng / Kong, Po Marn / Lew, Yii Jen / Lim, Choon Seng / Lim, Ting Ting Jayne / Lu, Kuo Fan Mark / Ooi, Peng Lim / Sng, Li-Hwei / Thoon, Koh Cheng

    Singapore medical journal

    2016  Band 57, Heft 3, Seite(n) 118–24; quiz 125

    Abstract: The Ministry of Health (MOH) has developed the clinical practice guidelines on Prevention, Diagnosis and Management of Tuberculosis to provide doctors and patients in Singapore with evidence-based treatment for tuberculosis. This article reproduces the ... ...

    Abstract The Ministry of Health (MOH) has developed the clinical practice guidelines on Prevention, Diagnosis and Management of Tuberculosis to provide doctors and patients in Singapore with evidence-based treatment for tuberculosis. This article reproduces the introduction and executive summary (with recommendations from the guidelines) from the MOH clinical practice guidelines on Prevention, Diagnosis and Management of Tuberculosis, for the information of SMJ readers. The chapters and page numbers mentioned in the reproduced extract refer to the full text of the guidelines, which are available from the Ministry of Health website: http://www.moh.gov.sg/content/moh_web/healthprofessionalsportal/doctors/guidelines/cpg_medical.html. The recommendations should be used with reference to the full text of the guidelines. Following this article are multiple choice questions based on the full text of the guidelines.
    Mesh-Begriff(e) Disease Management ; Evidence-Based Medicine/methods ; Government ; Humans ; Morbidity/trends ; Practice Guidelines as Topic ; Singapore/epidemiology ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2016-03
    Erscheinungsland Singapore
    Dokumenttyp Journal Article ; Review
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2016051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Severe acute respiratory syndrome (SARS): imaging findings during the acute and recovery phases of disease.

    Goh, Jeffrey Seow-Kuang / Tsou, Ian Yu-Yan / Kaw, Gregory Jon-Leng

    Journal of thoracic imaging

    2003  Band 18, Heft 3, Seite(n) 195–199

    Abstract: Severe acute respiratory syndrome (SARS) is a new form of atypical pneumonia, which has become a major health crisis in East Asia and Canada, with the potential for becoming the next worldwide epidemic. Until the validation of diagnostic kits is ... ...

    Abstract Severe acute respiratory syndrome (SARS) is a new form of atypical pneumonia, which has become a major health crisis in East Asia and Canada, with the potential for becoming the next worldwide epidemic. Until the validation of diagnostic kits is completed, clinical findings, contact history, and radiologic findings are the key to diagnosis of this disease. The imaging findings on conventional radiographs and computed tomography (CT) in the acute phase as well as during recovery are presented.
    Mesh-Begriff(e) Acute Disease ; Adult ; Convalescence ; Female ; Humans ; Radiography, Thoracic ; Severe Acute Respiratory Syndrome/diagnostic imaging ; Tomography, X-Ray Computed
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2003-07-16
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 632900-7
    ISSN 1536-0237 ; 0883-5993
    ISSN (online) 1536-0237
    ISSN 0883-5993
    DOI 10.1097/00005382-200307000-00010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Hypocortisolism in survivors of severe acute respiratory syndrome (SARS).

    Leow, Melvin Khee-Shing / Kwek, Daniel Seow-Khee / Ng, Alan Wei-Keong / Ong, Kian-Chung / Kaw, Gregory Jon-Leng / Lee, Lawrence Soon-U

    Clinical endocrinology

    2005  Band 63, Heft 2, Seite(n) 197–202

    Abstract: Objective: Following the severe acute respiratory syndrome (SARS) outbreak, many survivors were observed to suffer from psychosomatic symptoms reminiscent of various endocrine disorders. Hence, we sought to determine the existence of any chronic ... ...

    Abstract Objective: Following the severe acute respiratory syndrome (SARS) outbreak, many survivors were observed to suffer from psychosomatic symptoms reminiscent of various endocrine disorders. Hence, we sought to determine the existence of any chronic endocrine sequelae in SARS survivors.
    Design, patients, measurements: Sixty-one survivors of SARS prospectively recruited were analysed for hormonal derangements 3 months following recovery. Patients with pre-existing endocrine disorders were excluded. Any endocrine abnormalities diagnosed were investigated and treated where indicated up to a year. Serial evaluation facilitated characterization of trends and prognostication of any endocrinological aberrations.
    Results: Twenty-four (39.3%) patients had evidence of hypocortisolism. The hypothalamic-pituitary-adrenal (HPA) axis dysfunction of the majority resolved within a year. Two (3.3%) of the hypocortisolic cohort had transient subclinical thyrotoxicosis. Four (6.7%) were biochemically hypothyroid, being comprised of three with central hypothyroidism and one with primary hypothyroidism. Two of the three with central hypothyroidism had concomitant central hypocortisolism. Eight had subnormal DHEAS levels.
    Conclusions: These preliminary findings highlight a possible aetiologic role of SARS-associated coronavirus in causing a reversible hypophysitis or direct hypothalamic effect, with the HPA axis affected more frequently than the HPT axis.
    Mesh-Begriff(e) Adrenocorticotropic Hormone/blood ; Adult ; Anti-Inflammatory Agents/therapeutic use ; Female ; Humans ; Hydrocortisone/blood ; Hydrocortisone/therapeutic use ; Hypothalamo-Hypophyseal System/physiopathology ; Male ; Methylprednisolone/therapeutic use ; Middle Aged ; Pituitary-Adrenal System/physiopathology ; Prednisolone/therapeutic use ; Prospective Studies ; Severe Acute Respiratory Syndrome/blood ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/physiopathology ; Thyroid Diseases/blood ; Thyroid Diseases/complications ; Thyroid Diseases/physiopathology
    Chemische Substanzen Anti-Inflammatory Agents ; Adrenocorticotropic Hormone (9002-60-2) ; Prednisolone (9PHQ9Y1OLM) ; Hydrocortisone (WI4X0X7BPJ) ; Methylprednisolone (X4W7ZR7023)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2005-07-05
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/j.1365-2265.2005.02325.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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