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  1. Artikel ; Online: Triglyceride-Glucose Index Associated with Future Renal Function Decline in the General Population.

    Yoshida, Daisuke / Ikeda, Shota / Shinohara, Keisuke / Kazurayama, Masaya / Tanaka, Shinji / Yamaizumi, Masamitsu / Nagayoshi, Hirokazu / Toyama, Kensuke / Kinugawa, Shintaro

    Journal of general internal medicine

    2024  

    Abstract: Background: The triglyceride-glucose index (TyG index), calculated as the logarithmic product of fasting triglyceride and glucose concentrations, is recognized as a simple marker of insulin resistance. However, the association between the TyG index and ... ...

    Abstract Background: The triglyceride-glucose index (TyG index), calculated as the logarithmic product of fasting triglyceride and glucose concentrations, is recognized as a simple marker of insulin resistance. However, the association between the TyG index and future decline of renal function remains unclear in the general population.
    Objective: To investigate whether the TyG index was associated with future decline of renal function in the general population who had not progressed to chronic kidney disease stage G2.
    Design: Retrospective longitudinal observational cohort study.
    Participants: Individuals who received a population-based health checkup at JA Ehime Kouseiren Checkup Center from 2010 to 2019 (n = 134,007). Individuals without data of baseline fasting triglyceride or glucose levels, or baseline and follow-up data of estimated glomerular filtration rate (eGFR), or those with baseline eGFR < 60 mL/min/1.73 m
    Main measures: Future renal function decline, defined as a ≥ 25% decrease in eGFR from baseline.
    Key results: Of 10,758 participants, 8,076 were classified into the low TyG index group (TyG index < 8.76, 1st to 3rd quartiles) and 2,682 into the high TyG index group (TyG index ≥ 8.76, 4th quartile). The mean follow-up period was 37.8 ± 23.6 months. The incidence rates of renal function decline were 0.31 and 0.69 per 100 person-years in the low and high TyG index groups, respectively. In multivariate Cox proportional hazard models, high TyG index was significantly associated with future renal function decline (hazard ratio 2.25, 95% CI 1.40-3.60). This association was consistent across subgroups stratified by age, sex, body mass index, baseline eGFR, and diagnosed hypertension, diabetes, or dyslipidemia.
    Conclusion: In the general population, high TyG index was associated with future renal function decline. The TyG index may be useful in identifying individuals at high risk for future renal function decline in the setting of health checkups.
    Sprache Englisch
    Erscheinungsdatum 2024-05-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-024-08809-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population.

    Ikeda, Shota / Shinohara, Keisuke / Tagawa, Koshiro / Tohyama, Takeshi / Kishimoto, Junji / Kazurayama, Masaya / Tanaka, Shinji / Yamaizumi, Masamitsu / Nagayoshi, Hirokazu / Toyama, Kensuke / Matsushima, Shouji / Tsutsui, Hiroyuki / Kinugawa, Shintaro

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 301

    Abstract: Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the ... ...

    Abstract Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the general population using a dataset of population-based health checkups from 2010 to 2019 including 19,825 participants. Electrocardiographic LVH was defined according to the Minnesota code. Renal function decline was defined as a decrease of ≥ 25% in the estimated glomerular filtration rate from baseline to < 60 mL/min/1.73 m
    Mesh-Begriff(e) Humans ; Hypertrophy, Left Ventricular/diagnosis ; Hypertension ; Kidney ; Blood Pressure ; Incidence ; Electrocardiography ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-51085-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Low-Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development.

    Abe, Yasunori / Toyama, Kensuke / Kazurayama, Masaya / Tanaka, Shinji / Yamaizumi, Masamitsu / Ueno, Megumi / Spin, Joshua M / Hato, Naohito / Mogi, Masaki

    The Laryngoscope

    2020  Band 131, Heft 4, Seite(n) E1287–E1295

    Abstract: Objective: Identification of undefined risk factors will be crucial for the development of therapeutic strategies in hearing impairment. Platelets are likely to affect the development of sudden sensorineural hearing loss, which is a primary risk factor ... ...

    Abstract Objective: Identification of undefined risk factors will be crucial for the development of therapeutic strategies in hearing impairment. Platelets are likely to affect the development of sudden sensorineural hearing loss, which is a primary risk factor for permanent hearing impairment. This implies that abnormal platelets might contribute to long-term hearing loss. This study investigated the role of platelets in the development of hearing impairment over a 5-year period.
    Methods: This study was a retrospective cohort study and consisted of a population-based survey, which was performed for 1,897 participants in 2014 to 2019. To evaluate the effect of platelet level on hearing ability, the subjects were divided into two groups: a high-normal platelet group (25 ∼ 40 × 10
    Results: Incidence of hearing impairment at low frequencies was significantly higher in the low-normal platelet group than in the high-normal group year over year. Low-normal platelet count associated with low-frequency hearing impairment (LFHI) incidence (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.15-4.76). In the low-normal platelet group, subjects whose counts declined from baseline developed more LFHI than those whose counts increased over time. Further, decreasing platelets appeared to be an independent risk factor contributing to the incidence of LFHI (OR, 2.10; 95%CI, 1.09-4.06) in the low-normal platelet group.
    Conclusion: Both a low-normal platelet and a declining platelet count were independently associated with the incidence of LFHI.
    Level of evidence: 3 Laryngoscope, 131:E1287-E1295, 2021.
    Mesh-Begriff(e) Adult ; Female ; Hearing Loss, Sudden/blood ; Hearing Loss, Sudden/epidemiology ; Humans ; Japan/epidemiology ; Male ; Platelet Count ; Prevalence ; Retrospective Studies ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2020-08-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28970
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ul II Zs.82: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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