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  1. Article ; Online: Novel benzo chromene derivatives: design, synthesis, molecular docking, cell cycle arrest, and apoptosis induction in human acute myeloid leukemia HL-60 cells.

    Abd El-Hameed, Rania H / Mohamed, Mosaad S / Awad, Samir M / Hassan, Bardes B / Khodair, Marwa Abd El-Fattah / Mansour, Yara E

    Journal of enzyme inhibition and medicinal chemistry

    2022  Volume 38, Issue 1, Page(s) 405–422

    Abstract: A series of benzo[ ...

    Abstract A series of benzo[
    MeSH term(s) Humans ; HL-60 Cells ; Benzopyrans/pharmacology ; Molecular Docking Simulation ; Caspase 8 ; Caspase 3 ; Cell Cycle Checkpoints ; Leukemia, Myeloid, Acute ; Proto-Oncogene Proteins c-bcl-2 ; Apoptosis
    Chemical Substances Benzopyrans ; Caspase 8 (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2022.2151592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3004: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Synthesis and Evaluation of Cytotoxic Activity of Certain Benzo[h]chromene Derivatives.

    Awad, Samir M / Mohamed, Mosaad S / Khodair, Marwa Abd El-Fattah / El-Hameed, Rania H Abd

    Anti-cancer agents in medicinal chemistry

    2020  Volume 21, Issue 8, Page(s) 963–986

    Abstract: Background: Benzo[h]chromenes attracted great attention because of their widespread biological activities, including anti-proliferate activity, and the discovery of novel effective anti-cancer agents is imperative.: Objective: The main objective was ... ...

    Abstract Background: Benzo[h]chromenes attracted great attention because of their widespread biological activities, including anti-proliferate activity, and the discovery of novel effective anti-cancer agents is imperative.
    Objective: The main objective was to synthesize new benzo[h]chromene derivatives and some reported derivatives, and then test all of them for their anti-cancer activities.
    Methods: The structures of the newly synthesized derivatives were confirmed by elemental and spectral analysis (IR, Mass,
    Results: Compounds 1a, 1c and 2b have the highest activities among all 35 tested compounds especially compound 1c.
    Conclusion: compound 1c has promising anti-cancer activities compared to the used standards and may need further modification and investigations.
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Benzopyrans/chemical synthesis ; Benzopyrans/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Colchicine/analogs & derivatives ; Colchicine/pharmacology ; Colchicine/standards ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/pharmacology ; Sorafenib/pharmacology ; Sorafenib/standards ; Structure-Activity Relationship ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/pharmacology
    Chemical Substances Antineoplastic Agents ; Benzopyrans ; Protein Kinase Inhibitors ; Tubulin Modulators ; colchicone ; Sorafenib (9ZOQ3TZI87) ; ErbB Receptors (EC 2.7.10.1) ; Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2020-09-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/1871520620666200925103742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5583: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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