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  1. Artikel: Regulation of Med1 protein by overexpression of BAP1 in breast cancer cells.

    Kim, Hyunju

    Molecular & cellular oncology

    2024  Band 11, Heft 1, Seite(n) 2347827

    Abstract: Med1 binds to a nuclear receptor and regulates transcription. Elevated Med1 protein expression promotes cancer growth in hormone-dependent breast and prostate cancers. Med1 protein expression was investigated by deubiquitinating enzymes (DUBs) ... ...

    Abstract Med1 binds to a nuclear receptor and regulates transcription. Elevated Med1 protein expression promotes cancer growth in hormone-dependent breast and prostate cancers. Med1 protein expression was investigated by deubiquitinating enzymes (DUBs) overexpression in breast cancer cell lines. Various DNA constructs of SRT-DUBs were overexpressed in the MCF7 cell line, and Med1 protein expression was investigated by western blotting. The cell growth and in vitro invasion assay were performed in BRCA1-associated protein 1 (BAP1) wild type and mutant (C91A) overexpressed cells. Ubiquitination of the Med1 protein was observed, and Med1 protein expression and transcriptional activity were verified by various DUBs overexpressed. Although Med1 protein expression increased upon the overexpression of BAP1, it was not affected by the overexpression of BAP1 mutant (C91A). BAP1 was increased by the E2 treatment, which has an important effect on the breast cancer growth, and cell growth was decreased by BAP1 C91A overexpression. However, metastatic capacities were decreased by BAP1. In addition, the binding between the Med1 and the BAP1 protein was observed. These data suggested that BAP1 regulated Med1 protein expression in breast cancer cells and involved in cancer cell growth and metastasis by binding to Med1 protein.
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2024.2347827
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Visualization of maternal IL-17a across the placental membrane.

    Kim, Hyunju

    Science progress

    2023  Band 106, Heft 3, Seite(n) 368504231195500

    Abstract: IL-17a is a pro-inflammatory cytokine produced primarily by T helper-17 cells. Several studies have shown that maternal IL-17a, associated with maternal immune activation (MIA), affects the developing brain. However, the mechanisms underlying maternal IL- ...

    Abstract IL-17a is a pro-inflammatory cytokine produced primarily by T helper-17 cells. Several studies have shown that maternal IL-17a, associated with maternal immune activation (MIA), affects the developing brain. However, the mechanisms underlying maternal IL-17a signaling remain partially unknown. This study detected trans-placental IL-17a passage using luminescent activity studies and an
    Mesh-Begriff(e) Female ; Pregnancy ; Animals ; Mice ; Placenta ; Signal Transduction ; Cell Line ; Brain ; RNA, Messenger/genetics
    Chemische Substanzen RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2023-08-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 128412-5
    ISSN 2047-7163 ; 0036-8504 ; 0302-1785
    ISSN (online) 2047-7163
    ISSN 0036-8504 ; 0302-1785
    DOI 10.1177/00368504231195500
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Alleviative Effect of Geniposide on Lipopolysaccharide-Stimulated Macrophages via Calcium Pathway.

    Kim, Hyun-Ju / Park, Wansu

    International journal of molecular sciences

    2024  Band 25, Heft 3

    Abstract: In this study, we investigated how geniposide (a bioactive ingredient of gardenia fruit) acts on lipopolysaccharide (LPS)-stimulated macrophages. Griess reagent assay, Fluo-4 calcium assay, dihydrorhodamine 123 assay, multiplex cytokine assay, ... ...

    Abstract In this study, we investigated how geniposide (a bioactive ingredient of gardenia fruit) acts on lipopolysaccharide (LPS)-stimulated macrophages. Griess reagent assay, Fluo-4 calcium assay, dihydrorhodamine 123 assay, multiplex cytokine assay, quantitative RT-PCR, and flow cytometry assay were used for this study. Data showed that geniposide at concentrations of 10, 25, and 50 μM reduced significantly the levels of nitric oxide, intracellular Ca
    Mesh-Begriff(e) Humans ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Calcium/metabolism ; Macrophages/metabolism ; Cytokines/metabolism ; Nitric Oxide/metabolism ; NF-kappa B/metabolism ; Inflammation/metabolism ; Iridoids
    Chemische Substanzen Lipopolysaccharides ; Calcium (SY7Q814VUP) ; geniposide (145295QLXY) ; Cytokines ; Nitric Oxide (31C4KY9ESH) ; NF-kappa B ; Iridoids
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031728
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Enhancing Safety in Tumescent Liposuction: Managing Sedation-Related Respiratory Issues and Serious Complications Under Deep Sedation with the Propofol-Ketamine Protocol.

    Kim, Eun Ju / Kim, Hyunju / Park, Younchan

    Aesthetic plastic surgery

    2024  Band 48, Heft 10, Seite(n) 1964–1976

    Abstract: Background: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, ...

    Abstract Background: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative.
    Methods: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol. The evaluation of patient safety involved an examination of potential adverse events with a specific focus on respiratory issues related to sedation, including instances of mask ventilation.
    Results: Among the 3094 cases, no fatalities were recorded. Noteworthy events included 43 mask ventilation instances, primarily occurring in the initial 10 min. Twelve cases experienced surgery cancellation due to various factors, including respiratory issues. Three patients were transferred to upper-level hospitals, while another three required blood transfusions. Vigilant management prevented significant complications, and other adverse events like venous thromboembolism (VTE), fat embolism, severe lidocaine toxicity, and so on were not observed.
    Conclusions: The analysis of 3094 tumescent liposuction cases highlighted the overall safety profile of the propofol-ketamine protocol under deep sedation. The scarcity of severe complications underscores its viability. The study emphasizes the significance of thorough preoperative assessments, careful patient selection, and awareness of potential complications. Prompt interventions, particularly in addressing sedation-related respiratory issues, further contribute to positive outcomes for patients.
    Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Mesh-Begriff(e) Humans ; Ketamine/adverse effects ; Ketamine/administration & dosage ; Retrospective Studies ; Propofol/adverse effects ; Propofol/administration & dosage ; Lipectomy/methods ; Lipectomy/adverse effects ; Female ; Deep Sedation/adverse effects ; Deep Sedation/methods ; Adult ; Male ; Middle Aged ; Young Adult ; Risk Assessment ; Patient Safety ; Cohort Studies ; Aged
    Chemische Substanzen Ketamine (690G0D6V8H) ; Propofol (YI7VU623SF)
    Sprache Englisch
    Erscheinungsdatum 2024-03-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-024-03963-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1296: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Multimodal neural correlates of dispositional resilience among healthy individuals.

    Kim, Hyun-Ju / Bang, Minji / Pae, Chongwon / Lee, Sang-Hyuk

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 9875

    Abstract: Resilient individuals are less likely to develop psychiatric disorders despite extreme psychological distress. This study investigated the multimodal structural neural correlates of dispositional resilience among healthy individuals. Participants ... ...

    Abstract Resilient individuals are less likely to develop psychiatric disorders despite extreme psychological distress. This study investigated the multimodal structural neural correlates of dispositional resilience among healthy individuals. Participants included 92 healthy individuals. The Korean version of the Connor-Davidson Resilience Scale and other psychological measures were used. Gray matter volumes (GMVs), cortical thickness, local gyrification index (LGI), and white matter (WM) microstructures were analyzed using voxel-based morphometry, FreeSurfer, and tract-based spatial statistics, respectively. Higher resilient individuals showed significantly higher GMVs in the inferior frontal gyrus (IFG), increased LGI in the insula, and lower fractional anisotropy values in the superior longitudinal fasciculus II (SLF II). These resilience's neural correlates were associated with good quality of life in physical functioning or general health and low levels of depression. Therefore, the GMVs in the IFG, LGI in the insula, and WM microstructures in the SLF II can be associated with resilience that contributes to emotional regulation, empathy, and social cognition.
    Mesh-Begriff(e) Humans ; Male ; Female ; Resilience, Psychological ; Adult ; Gray Matter/diagnostic imaging ; Gray Matter/physiology ; Gray Matter/anatomy & histology ; White Matter/diagnostic imaging ; White Matter/physiology ; Young Adult ; Magnetic Resonance Imaging ; Healthy Volunteers ; Brain/physiology ; Brain/diagnostic imaging ; Quality of Life
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60619-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Algae development in rivers with artificially constructed weirs: Dominant influence of discharge over temperature.

    Kim, Hyunju / Lee, Gyesik / Lee, Chang-Gu / Park, Seong-Jik

    Journal of environmental management

    2024  Band 355, Seite(n) 120551

    Abstract: Algal blooms contribute to water quality degradation, unpleasant odors, taste issues, and the presence of harmful substances in artificially constructed weirs. Mitigating these adverse effects through effective algal bloom management requires identifying ...

    Abstract Algal blooms contribute to water quality degradation, unpleasant odors, taste issues, and the presence of harmful substances in artificially constructed weirs. Mitigating these adverse effects through effective algal bloom management requires identifying the contributing factors and predicting algal concentrations. This study focused on the upstream region of the Seungchon Weir in Korea, which is characterized by elevated levels of total nitrogen and phosphorus due to a significant influx of water from a sewage treatment plant. We employed four distinct machine learning models to predict chlorophyll-a (Chl-a) concentrations and identified the influential variables linked to local algal bloom events. The gradient boosting model enabled an in-depth exploration of the intricate relationships between algal occurrence and water quality parameters, enabling accurate identification of the causal factors. The models identified the discharge flow rate (D-Flow) and water temperature as the primary determinants of Chl-a levels, with feature importance values of 0.236 and 0.212, respectively. Enhanced model precision was achieved by utilizing daily average D-Flow values, with model accuracy and significance of the D-Flow amplifying as the temporal span of daily averaging increased. Elevated Chl-a concentrations correlated with diminished D-Flow and temperature, highlighting the pivotal role of D-Flow in regulating Chl-a concentration. This trend can be attributed to the constrained discharge of the Seungchon Weir during winter. Calculating the requisite D-Flow to maintain a desirable Chl-a concentration of up to 20 mg/m
    Mesh-Begriff(e) Rivers ; Temperature ; Environmental Monitoring ; Chlorophyll A ; Chlorophyll/analysis ; Water Quality ; Eutrophication ; Nitrogen/analysis ; Phosphorus/analysis ; China
    Chemische Substanzen Chlorophyll A (YF5Q9EJC8Y) ; Chlorophyll (1406-65-1) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W)
    Sprache Englisch
    Erscheinungsdatum 2024-03-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120551
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Bonn

    Z 7556: Hefte anzeigen

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  7. Artikel ; Online: A dataset of ambient sensors in a meeting room for activity recognition.

    Kim, Hyunju / Kim, Geon / Lee, Taehoon / Kim, Kisoo / Lee, Dongman

    Scientific data

    2024  Band 11, Heft 1, Seite(n) 516

    Abstract: As IoT technology advances, using machine learning to detect user activities emerges as a promising strategy for delivering a variety of smart services. It is essential to have access to high-quality data that also respects privacy concerns and data ... ...

    Abstract As IoT technology advances, using machine learning to detect user activities emerges as a promising strategy for delivering a variety of smart services. It is essential to have access to high-quality data that also respects privacy concerns and data streams from ambient sensors in the surrounding environment meet this requirement. However, despite growing interest in research, there is a noticeable lack of datasets from ambient sensors designed for public spaces, as opposed to those for private settings. To bridge this gap, we design the DOO-RE dataset within an actual meeting room environment, equipped with three types of ambient sensors: those triggered by actuators, users, and the environment itself. This dataset is compiled from the activities of over twenty students throughout a period of four months. DOO-RE provides reliable and purpose-oriented activity data in a public setting, with activity labels verified by multiple annotators through a process of cross-validation to guarantee data integrity. DOO-RE categorizes nine different types of activities and facilitates the study of both single and group activities. We are optimistic that DOO-RE will play a significant role in advancing human activity recognition technologies, enhancing smart automation systems, and enabling the rapid setup of smart spaces through ambient sensors.
    Sprache Englisch
    Erscheinungsdatum 2024-05-21
    Erscheinungsland England
    Dokumenttyp Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-024-03344-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Moutan Cortex Extract Modulates Macrophage Activation via Lipopolysaccharide-Induced Calcium Signaling and ER Stress-CHOP Pathway.

    Kim, Hyun-Ju / Kim, Do-Hoon / Park, Wansu

    International journal of molecular sciences

    2023  Band 24, Heft 3

    Abstract: Moutan Cortex, ...

    Abstract Moutan Cortex,
    Mesh-Begriff(e) Animals ; Mice ; Calcium/metabolism ; Calcium Signaling ; Cytokines/metabolism ; Hydrogen Peroxide/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Macrophage Activation ; Macrophages/metabolism ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Paeonia/metabolism ; RAW 264.7 Cells ; Endoplasmic Reticulum Stress
    Chemische Substanzen Calcium (SY7Q814VUP) ; Cytokines ; Hydrogen Peroxide (BBX060AN9V) ; Lipopolysaccharides ; moutan cortex ; NF-kappa B ; Nitric Oxide (31C4KY9ESH)
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032062
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  9. Artikel: Functional Role of Phospholipase D in Bone Metabolism.

    Kim, Hyun-Ju / Lee, Dong-Kyo / Choi, Je-Yong

    Journal of bone metabolism

    2023  Band 30, Heft 2, Seite(n) 117–125

    Abstract: Phospholipase D (PLD) proteins are major enzymes that regulate various cellular functions, such as cell growth, cell migration, membrane trafficking, and cytoskeletal dynamics. As they are responsible for such important biological functions, PLD proteins ...

    Abstract Phospholipase D (PLD) proteins are major enzymes that regulate various cellular functions, such as cell growth, cell migration, membrane trafficking, and cytoskeletal dynamics. As they are responsible for such important biological functions, PLD proteins have been considered promising therapeutic targets for various diseases, including cancer and vascular and neurological diseases. Intriguingly, emerging evidence indicates that PLD1 and PLD2, 2 major mammalian PLD isoenzymes, are the key regulators of bone remodeling; this suggests that these isozymes could be used as potential therapeutic targets for bone diseases, such as osteoporosis and rheumatoid arthritis. PLD1 or PLD2 deficiency in mice can lead to decreased bone mass and dysregulated bone homeostasis. Although both mutant mice exhibit similar skeletal phenotypes, PLD1 and PLD2 play distinct and nonredundant roles in bone cell function. This review summarizes the physiological roles of PLD1 and PLD2 in bone metabolism, focusing on recent findings of the biological functions and action mechanisms of PLD1 and PLD2 in bone cells.
    Sprache Englisch
    Erscheinungsdatum 2023-05-31
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2765291-9
    ISSN 2287-7029 ; 2287-6375
    ISSN (online) 2287-7029
    ISSN 2287-6375
    DOI 10.11005/jbm.2023.30.2.117
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  10. Artikel ; Online: Experiences Pertaining to Successful Aging in Middle-Aged Women in South Korea.

    Lee, Do-Young / Kim, Hyun-Ju / Jo, A-Young

    International journal of environmental research and public health

    2023  Band 20, Heft 19

    Abstract: This study aimed to analyze and gain an in-depth understanding of the experiences pertaining to successful aging in middle-aged women in South Korea. A sample of 12 middle-aged women, capable of sharing their lived experiences, was divided into three age- ...

    Abstract This study aimed to analyze and gain an in-depth understanding of the experiences pertaining to successful aging in middle-aged women in South Korea. A sample of 12 middle-aged women, capable of sharing their lived experiences, was divided into three age-based groups: those in their 40s, those in their 50s, and those aged 60-65 years. The collected data were analyzed using Colaizzi's phenomenological method. Five theme clusters and ten themes emerged. The experiences of successful aging among middle-aged women were categorized as: "Coping with changes in the mind and body", "Financially stable life", "Undergoing the aging process with a healthy family", "Preparations for dying well", and "Pursuing a meaningful, harmonious life". These findings highlight the need for programs that prepare middle-aged women to positively accept and enjoy older adulthood by identifying and addressing the factors essential for successful aging and reducing any negative emotions attached to aging and older adulthood.
    Mesh-Begriff(e) Middle Aged ; Humans ; Female ; Aged ; Aging/psychology ; Republic of Korea ; Adaptation, Psychological ; Data Collection ; Qualitative Research
    Sprache Englisch
    Erscheinungsdatum 2023-10-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20196882
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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