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  1. Artikel ; Online: Fourteen

    Webb, Hattie E / Kim, Justin Y / Tagg, Kaitlin A / Kapsak, Curtis J / Tobolowsky, Farrell / Birhane, Meseret G / Francois Watkins, Louise / Folster, Jason P

    Microbiology resource announcements

    2022  Band 11, Heft 5, Seite(n) e0011822

    Abstract: In the United States, reports of Salmonella enterica ... ...

    Abstract In the United States, reports of Salmonella enterica carrying
    Sprache Englisch
    Erscheinungsdatum 2022-04-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00118-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline.

    Wang, Guanning / Lyudovyk, Olga / Kim, Justin Y / Lin, Ya-Hui / Elhanati, Yuval / Mathew, Divij / Wherry, E John / Herati, Ramin S / Greenplate, Allison R / Greenbaum, Benjamin / Vardhana, Santosha A / Huang, Alexander C

    STAR protocols

    2023  Band 4, Heft 2, Seite(n) 102289

    Abstract: The current abundance of immunotherapy clinical trials presents an opportunity to learn about the underlying mechanisms and pharmacodynamic effects of novel drugs on the human immune system. Here, we present a protocol to study how these immune responses ...

    Abstract The current abundance of immunotherapy clinical trials presents an opportunity to learn about the underlying mechanisms and pharmacodynamic effects of novel drugs on the human immune system. Here, we present a protocol to study how these immune responses impact clinical outcomes using large-scale high-throughput immune profiling of clinical cohorts. We describe the Human Immune Profiling Pipeline, which comprises an end-to-end solution from flow cytometry results to computational approaches and unsupervised patient clustering based on lymphocyte landscape. For complete details on the use and execution of this protocol, please refer to Lyudovyk et al. (2022).
    Sprache Englisch
    Erscheinungsdatum 2023-05-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102289
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Five Complete

    Webb, Hattie E / Tagg, Kaitlin A / Kim, Justin Y / Miller, Elizabeth A / Johnson, Timothy J / Peñil-Celis, Arancha / de la Cruz, Fernando / Folster, Jason P

    Microbiology resource announcements

    2022  Band 11, Heft 7, Seite(n) e0038822

    Abstract: Between 2018 and 2019, Salmonella enterica serotype Reading caused a large, multistate outbreak linked to contact with raw turkey products in the United States. Here, we provide five Salmonella Reading reference genomes collected from US patients between ...

    Abstract Between 2018 and 2019, Salmonella enterica serotype Reading caused a large, multistate outbreak linked to contact with raw turkey products in the United States. Here, we provide five Salmonella Reading reference genomes collected from US patients between 2016 and 2018.
    Sprache Englisch
    Erscheinungsdatum 2022-06-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00388-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Genome Sequences of 18 Salmonella enterica Serotype Hadar Strains Collected from Patients in the United States.

    Webb, Hattie E / Kim, Justin Y / Tagg, Kaitlin A / de la Cruz, Fernando / Peñil-Celis, Arancha / Tolar, Beth / Ellison, Zachary / Schwensohn, Colin / Brandenburg, Joshua / Nichols, Megin / Folster, Jason P

    Microbiology resource announcements

    2022  Band 11, Heft 10, Seite(n) e0052222

    Abstract: Despite being linked to a number of recent poultry-associated outbreaks in the United States, few reference genomes are available for Salmonella enterica serotype Hadar. Here, we address this need by reporting 18 Salmonella Hadar genomes from samples ... ...

    Abstract Despite being linked to a number of recent poultry-associated outbreaks in the United States, few reference genomes are available for Salmonella enterica serotype Hadar. Here, we address this need by reporting 18 Salmonella Hadar genomes from samples collected from patients in the United States between 2014 and 2020.
    Sprache Englisch
    Erscheinungsdatum 2022-08-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00522-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses.

    Lyudovyk, Olga / Kim, Justin Y / Qualls, David / Hwee, Madeline A / Lin, Ya-Hui / Boutemine, Sawsan R / Elhanati, Yuval / Solovyov, Alexander / Douglas, Melanie / Chen, Eunise / Babady, N Esther / Ramanathan, Lakshmi / Vedantam, Pallavi / Bandlamudi, Chaitanya / Gouma, Sigrid / Wong, Philip / Hensley, Scott E / Greenbaum, Benjamin / Huang, Alexander C /
    Vardhana, Santosha A

    Cancer cell

    2022  Band 40, Heft 7, Seite(n) 738–753.e5

    Abstract: How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, more than 20% of whom had delayed viral clearance. ...

    Abstract How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, more than 20% of whom had delayed viral clearance. Delayed clearance was associated with loss of antibodies to nucleocapsid and spike proteins with a compensatory increase in functional T cell responses. High-dimensional analysis of peripheral blood samples demonstrated increased CD8
    Mesh-Begriff(e) CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; COVID-19 ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunologic Memory ; Receptors, Antigen, T-Cell ; SARS-CoV-2
    Chemische Substanzen Receptors, Antigen, T-Cell
    Sprache Englisch
    Erscheinungsdatum 2022-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2022.05.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Sequencing and Characterization of Five Extensively Drug-Resistant Salmonella enterica Serotype Typhi Isolates Implicated in Human Infections from Punjab, Pakistan.

    Tagg, Kaitlin A / Amir, Afreenish / Ikram, Aamer / Chen, Jessica C / Kim, Justin Y / Meservey, Elizabeth / Joung, Yoo J / Halpin, Jessica L / Batra, Dhwani / Leeper, Molly M / Katz, Lee S / Saeed, Asim / Freeman, Molly / Watkins, Louise Francois / Salman, Muhammad / Folster, Jason P

    Microbiology resource announcements

    2020  Band 9, Heft 13

    Abstract: A large outbreak of extensively drug-resistant (XDR) ...

    Abstract A large outbreak of extensively drug-resistant (XDR)
    Sprache Englisch
    Erscheinungsdatum 2020-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01466-19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer.

    Bange, Erin M / Han, Nicholas A / Wileyto, Paul / Kim, Justin Y / Gouma, Sigrid / Robinson, James / Greenplate, Allison R / Porterfield, Florence / Owoyemi, Olutosin / Naik, Karan / Zheng, Cathy / Galantino, Michael / Weisman, Ariel R / Ittner, Caroline A G / Kugler, Emily M / Baxter, Amy E / Oniyide, Olutwatosin / Agyekum, Roseline S / Dunn, Thomas G /
    Jones, Tiffanie K / Giannini, Heather M / Weirick, Madison E / McAllister, Christopher M / Babady, N Esther / Kumar, Anita / Widman, Adam J / DeWolf, Susan / Boutemine, Sawsan R / Roberts, Charlotte / Budzik, Krista R / Tollett, Susan / Wright, Carla / Perloff, Tara / Sun, Lova / Mathew, Divij / Giles, Josephine R / Oldridge, Derek A / Wu, Jennifer E / Alanio, Cécile / Adamski, Sharon / Garfall, Alfred L / Vella, Laura / Kerr, Samuel J / Cohen, Justine V / Oyer, Randall A / Massa, Ryan / Maillard, Ivan P / Maxwell, Kara N / Reilly, John P / Maslak, Peter G / Vonderheide, Robert H / Wolchok, Jedd D / Hensley, Scott E / Wherry, E John / Meyer, Nuala / DeMichele, Angela M / Vardhana, Santosha A / Mamtani, Ronac / Huang, Alexander C

    Research square

    2021  

    Abstract: Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer patients hospitalized for COVID-19 at the University of Pennsylvania Health ... ...

    Abstract Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer patients hospitalized for COVID-19 at the University of Pennsylvania Health System, we found that patients with hematologic cancers had a significantly higher mortality relative to patients with solid cancers after accounting for confounders including ECOG performance status and active cancer status. We performed flow cytometric and serologic analyses of 106 cancer patients and 113 non-cancer controls from two additional cohorts at Penn and Memorial Sloan Kettering Cancer Center. Patients with solid cancers exhibited an immune phenotype similar to non-cancer patients during acute COVID-19 whereas patients with hematologic cancers had significant impairment of B cells and SARS-CoV-2-specific antibody responses. High dimensional analysis of flow cytometric data revealed 5 distinct immune phenotypes. An immune phenotype characterized by CD8 T cell depletion was associated with a high viral load and the highest mortality of 71%, among all cancer patients. In contrast, despite impaired B cell responses, patients with hematologic cancers and preserved CD8 T cells had a lower viral load and mortality. These data highlight the importance of CD8 T cells in acute COVID-19, particularly in the setting of impaired humoral immunity. Further, depletion of B cells with anti-CD20 therapy resulted in almost complete abrogation of SARS-CoV-2-specific IgG and IgM antibodies, but was not associated with increased mortality compared to other hematologic cancers, when adequate CD8 T cells were present. Finally, higher CD8 T cell counts were associated with improved overall survival in patients with hematologic cancers. Thus, CD8 T cells likely compensate for deficient humoral immunity and influence clinical recovery of COVID-19. These observations have important implications for cancer and COVID-19-directed treatments, immunosuppressive therapies, and for understanding the role of B and T cells in acute COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2021-02-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-162289/v1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: CD8

    Bange, Erin M / Han, Nicholas A / Wileyto, Paul / Kim, Justin Y / Gouma, Sigrid / Robinson, James / Greenplate, Allison R / Hwee, Madeline A / Porterfield, Florence / Owoyemi, Olutosin / Naik, Karan / Zheng, Cathy / Galantino, Michael / Weisman, Ariel R / Ittner, Caroline A G / Kugler, Emily M / Baxter, Amy E / Oniyide, Olutwatosin / Agyekum, Roseline S /
    Dunn, Thomas G / Jones, Tiffanie K / Giannini, Heather M / Weirick, Madison E / McAllister, Christopher M / Babady, N Esther / Kumar, Anita / Widman, Adam J / DeWolf, Susan / Boutemine, Sawsan R / Roberts, Charlotte / Budzik, Krista R / Tollett, Susan / Wright, Carla / Perloff, Tara / Sun, Lova / Mathew, Divij / Giles, Josephine R / Oldridge, Derek A / Wu, Jennifer E / Alanio, Cécile / Adamski, Sharon / Garfall, Alfred L / Vella, Laura A / Kerr, Samuel J / Cohen, Justine V / Oyer, Randall A / Massa, Ryan / Maillard, Ivan P / Maxwell, Kara N / Reilly, John P / Maslak, Peter G / Vonderheide, Robert H / Wolchok, Jedd D / Hensley, Scott E / Wherry, E John / Meyer, Nuala J / DeMichele, Angela M / Vardhana, Santosha A / Mamtani, Ronac / Huang, Alexander C

    Nature medicine

    2021  Band 27, Heft 7, Seite(n) 1280–1289

    Abstract: Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hospitalized for COVID-19, patients with ... ...

    Abstract Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hospitalized for COVID-19, patients with hematologic cancer had higher mortality relative to patients with solid cancer. In two additional cohorts, flow cytometric and serologic analyses demonstrated that patients with solid cancer and patients without cancer had a similar immune phenotype during acute COVID-19, whereas patients with hematologic cancer had impairment of B cells and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody responses. Despite the impaired humoral immunity and high mortality in patients with hematologic cancer who also have COVID-19, those with a greater number of CD8 T cells had improved survival, including those treated with anti-CD20 therapy. Furthermore, 77% of patients with hematologic cancer had detectable SARS-CoV-2-specific T cell responses. Thus, CD8 T cells might influence recovery from COVID-19 when humoral immunity is deficient. These observations suggest that CD8 T cell responses to vaccination might provide protection in patients with hematologic cancer even in the setting of limited humoral responses.
    Mesh-Begriff(e) Aged ; Antibodies, Viral/immunology ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/complications ; COVID-19/immunology ; COVID-19/mortality ; Cohort Studies ; Female ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/immunology ; Humans ; Immunity, Cellular/immunology ; Immunity, Humoral/immunology ; Immunophenotyping ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasms/complications ; Neoplasms/immunology ; Proportional Hazards Models ; Prospective Studies ; SARS-CoV-2 ; Survival Rate
    Chemische Substanzen Antibodies, Viral
    Sprache Englisch
    Erscheinungsdatum 2021-05-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-021-01386-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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