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  1. Artikel ; Online: The impact of delayed access to COVID-19 vaccines in low- and lower-middle-income countries.

    Duroseau, Brenice / Kipshidze, Nodar / Limaye, Rupali Jayant

    Frontiers in public health

    2023  Band 10, Seite(n) 1087138

    Abstract: Introduction: A majority of low-income (LIC) and lower-middle-income countries (LMIC) were unable to achieve at least 10% population coverage during initial vaccine rollouts, despite the rapid development of the coronavirus disease 2019 (COVID-19) ... ...

    Abstract Introduction: A majority of low-income (LIC) and lower-middle-income countries (LMIC) were unable to achieve at least 10% population coverage during initial vaccine rollouts, despite the rapid development of the coronavirus disease 2019 (COVID-19) vaccines. Nearly three years into this pandemic, evaluating the impact of inequities in vaccine access, uptake, and availability is long overdue. We hypothesized that a delay in receiving COVID-19 vaccines was associated with an increased toll on cumulative cases and mortality. Furthermore, this relationship was modified by the size of a country's economy.
    Methods: We performed an ecological study assessing these relationships, in which a country's economic standing was assessed by world bank income classification, gross domestic product based on the purchasing power parity (GDP PPP) per capita category, and crude GDP PPP.
    Results: Countries with the smallest economies reported first vaccination much later than larger economies on all three rankings, as much as 100 days longer. Among low-income countries, a one-day increase until the first vaccination was associated with a 1.92% (95% CI: 0.100, 3.87) increase in cumulative cases when compared to high-income countries (
    Conclusion: Economic standing modified the effects of delayed access to COVID-19 vaccination on cumulative cases and mortality, in which LMICs tended to fare worse in outcomes than high-income countries despite the eventual rollout of vaccines. These findings highlight the importance of prioritizing equitable and timely access to COVID-19 vaccines across all countries, irrespective of economic size. Future studies should examine the impacts that vaccine inequities had on local transmission dynamics.
    Mesh-Begriff(e) Humans ; COVID-19 Vaccines ; Developing Countries ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccination ; Vaccines
    Chemische Substanzen COVID-19 Vaccines ; Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-01-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1087138
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Incorporating endogenous human behavior in models of COVID-19 transmission: A systematic scoping review.

    Hamilton, Alisa / Haghpanah, Fardad / Tulchinsky, Alexander / Kipshidze, Nodar / Poleon, Suprena / Lin, Gary / Du, Hongru / Gardner, Lauren / Klein, Eili

    Dialogues in health

    2024  Band 4, Seite(n) 100179

    Abstract: Background: During the COVID-19 pandemic there was a plethora of dynamical forecasting models created, but their ability to effectively describe future trajectories of disease was mixed. A major challenge in evaluating future case trends was forecasting ...

    Abstract Background: During the COVID-19 pandemic there was a plethora of dynamical forecasting models created, but their ability to effectively describe future trajectories of disease was mixed. A major challenge in evaluating future case trends was forecasting the behavior of individuals. When behavior was incorporated into models, it was primarily incorporated exogenously (e.g., fitting to cellphone mobility data). Fewer models incorporated behavior endogenously (e.g., dynamically changing a model parameter throughout the simulation).
    Methods: This review aimed to qualitatively characterize models that included an adaptive (endogenous) behavioral element in the context of COVID-19 transmission. We categorized studies into three approaches: 1) feedback loops, 2) game theory/utility theory, and 3) information/opinion spread.
    Findings: Of the 92 included studies, 72% employed a feedback loop, 27% used game/utility theory, and 9% used a model if information/opinion spread. Among all studies, 89% used a compartmental model alone or in combination with other model types. Similarly, 15% used a network model, 11% used an agent-based model, 7% used a system dynamics model, and 1% used a Markov chain model. Descriptors of behavior change included mask-wearing, social distancing, vaccination, and others. Sixty-eight percent of studies calibrated their model to observed data and 25% compared simulated forecasts to observed data. Forty-one percent of studies compared versions of their model with and without endogenous behavior. Models with endogenous behavior tended to show a smaller and delayed initial peak with subsequent periodic waves.
    Interpretation: While many COVID-19 models incorporated behavior exogenously, these approaches may fail to capture future adaptations in human behavior, resulting in under- or overestimates of disease burden. By incorporating behavior endogenously, the next generation of infectious disease models could more effectively predict outcomes so that decision makers can better prepare for and respond to epidemics.
    Funding: This study was funded in-part by Centers for Disease Control and Prevention (CDC)
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2772-6533
    ISSN (online) 2772-6533
    DOI 10.1016/j.dialog.2024.100179
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Response to Letter to the Editor: Left Gastric Artery Embolization for Weight Loss-a Dead-End Procedure.

    Fried, Martin / Kipshidze, Nodar

    Obesity surgery

    2019  Band 29, Heft 6, Seite(n) 1939–1941

    Mesh-Begriff(e) Bariatrics ; Embolization, Therapeutic ; Gastric Artery ; Humans ; Obesity ; Obesity, Morbid/surgery ; Weight Loss
    Sprache Englisch
    Erscheinungsdatum 2019-03-15
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-019-03811-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: COVID-19 Vaccines: Special Considerations for the Obese Population.

    Kipshidze, Nicholas / Kipshidze, Nodar / Fried, Martin

    Obesity surgery

    2021  Band 31, Heft 8, Seite(n) 3854–3856

    Mesh-Begriff(e) COVID-19 ; COVID-19 Vaccines ; Humans ; Obesity, Morbid/surgery ; SARS-CoV-2
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2021-04-08
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-021-05404-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Photodynamic and sonodynamic therapy of acute hypoxemic respiratory failure in patients with COVID-19.

    Kipshidze, Nicholas / Yeo, Nicholas / Kipshidze, Nodar

    Photodiagnosis and photodynamic therapy

    2020  Band 31, Seite(n) 101961

    Mesh-Begriff(e) Acute Disease ; COVID-19 ; Cause of Death ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Critical Illness/mortality ; Disease Progression ; Female ; Humans ; Hypoxia/drug therapy ; Hypoxia/etiology ; Male ; Pandemics/statistics & numerical data ; Photochemotherapy/methods ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Respiratory Insufficiency/drug therapy ; Risk Assessment ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/epidemiology ; Survival Analysis
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-17
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2020.101961
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Transcatheter Endoluminal Phototherapy as a Possible Adjunct Treatment for Patients with COVID-19.

    Kipshidze, Nicholas N / Kipshidze, Nodar / Horn, Joseph B

    Photobiomodulation, photomedicine, and laser surgery

    2020  Band 38, Heft 10, Seite(n) 579–580

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Catheterization/instrumentation ; Coronavirus Infections/therapy ; Endovascular Procedures/instrumentation ; Humans ; Pandemics ; Phototherapy/instrumentation ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-18
    Erscheinungsland United States
    Dokumenttyp Letter
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2020.4884
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Human Placental Mesenchymal Stem Cells for the Treatment of ARDS in Rat.

    Kakabadze, Zurab / Kipshidze, Nicholas / Paresishvili, Teona / Kipshidze, Nodar / Vadachkoria, Zurab / Chakhunashvili, David

    Stem cells international

    2022  Band 2022, Seite(n) 8418509

    Abstract: The acute respiratory distress syndrome (ARDS) is one of the main causes of high mortality in patients with coronavirus (COVID-19). In recent years, due to the coronavirus pandemic, the number of patients with ARDS has increased significantly. ... ...

    Abstract The acute respiratory distress syndrome (ARDS) is one of the main causes of high mortality in patients with coronavirus (COVID-19). In recent years, due to the coronavirus pandemic, the number of patients with ARDS has increased significantly. Unfortunately, until now, there are no effective treatments for ARDS caused by COVID-19. Many drugs are either ineffective or have a low effect. Currently, there have been reports of efficient use of mesenchymal stem cells (MSCs) for the treatment of ARDS caused by COVID-19. We investigated the influence of freeze-dried human placenta-derived mesenchymal stem cells (HPMSCs) in ARDS rat model. All animals have received intratracheal injection of 6 mg/kg of lipopolysaccharide (LPS). The rats were randomly divided into five groups: I: LPS, II: LPS+dexamethasone, III: LPS+HPMSCs, IV: HPMSC, and V: saline. ARDS observation time was short-term and amounted to 168 hours. The study has shown that HPMSCs are able to migrate and attach to damaged lung tissue, contributing to the resolution of pathology, restoration of function, and tissue repair in the alveolar space. Studies have also shown that the administration of HPMSCs in animals with ARDS model significantly reduced the levels of key cytokines such as IL-1
    Sprache Englisch
    Erscheinungsdatum 2022-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2022/8418509
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: A novel therapeutic vaccine targeting the soluble TNFα receptor II to limit the progression of cardiovascular disease: AtheroVax™.

    Iversen, Patrick L / Kipshidze, Nicholas / Kipshidze, Nodar / Dangas, George / Ramacciotti, Eduardo / Kakabadze, Zurab / Fareed, Jawed

    Frontiers in cardiovascular medicine

    2023  Band 10, Seite(n) 1206541

    Abstract: The burden of atherosclerotic cardiovascular disease contributes to a large proportion of morbidity and mortality, globally. Vaccination against atherosclerosis has been proposed for over 20 years targeting different mediators of atherothrombosis; ... ...

    Abstract The burden of atherosclerotic cardiovascular disease contributes to a large proportion of morbidity and mortality, globally. Vaccination against atherosclerosis has been proposed for over 20 years targeting different mediators of atherothrombosis; however, these have not been adequately evaluated in human clinical trials to assess safety and efficacy. Inflammation is a driver of atherosclerosis, but inflammatory mediators are essential components of the immune response. Only pathogenic forms of sTNFR2 are acted upon while preserving the membrane-bound (wild-type) TNFR2 contributions to a non-pathogenic immune response. We hypothesize that the inhibition of sTNRF2 will be more specific and offer long-term treatment options. Here we describe pre-clinical findings of an sTNFR2-targeting peptide vaccine (AtheroVax™) in a mouse model. The multiple pathways to synthesis of the soluble TNFRII receptor (sTNFRII) were identified as sTNFRII(PC), sTNFRII(Δ7), and sTNFRII(Δ7,9). The sTNFRII(Δ7) peptide, NH2-DFALPVEKPLCLQR-COOH is specific to sTNFR2 based on an mRNA splice-variant in which exon 6 is joined to exon 8. The role of sTNFRII(Δ7) as a mediator of prolonged TNFα activity by preventing degradation and clearance was investigated. Inflammation is a critical driver of onset, progression and expansion of atherosclerosis. The TNFα ligand represents a driver of inflammation that is mediated by a splice variant of TNFR2, referred to as sTNFRII(Δ7). The multiple forms of TNFRII, both membrane bound and soluble, are associated with distinctly different phenotypes. sTNFRII(PC) and sTNFRII(Δ7) are not equivalent to etanercept because they lack a clearance mechanism. The unique peptide associated with sTNFRII(Δ7) contains a linear B-cell epitope with amino acids from both exon 6 and exon 8 supporting the vaccine design. Animal studies to evaluate the vaccine are ongoing, and results will be forthcoming. We describe a peptide vaccine targeting sTNFR2 in limiting the progression of atherosclerosis. A therapeutic vaccine limiting the progression of atherosclerosis will greatly contribute to the reduction in morbidity and mortality from cardiovascular disease. It is likely the vaccine will be used in combination with the current standards of care and lifestyle modifications.
    Sprache Englisch
    Erscheinungsdatum 2023-07-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1206541
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Metabolic Outcomes of Percutaneous Transcathether Bariatric Embolotherapy: Insights from an RCT.

    Fried, Martin / Kipshidze, Nodar / Sramkrova, Petra / Rosen, Robert / Neuzil, Petr / Kipshidze, Nicholas / Reddy, Vivek

    Obesity surgery

    2021  Band 31, Heft 6, Seite(n) 2784–2786

    Mesh-Begriff(e) Bariatric Surgery ; Bariatrics ; Embolization, Therapeutic ; Humans ; Obesity, Morbid/surgery ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2021-02-19
    Erscheinungsland United States
    Dokumenttyp Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-021-05259-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Photodynamic and sonodynamic therapy of acute hypoxemic respiratory failure in patients with COVID-19

    Kipshidze, Nicholas / Yeo, Nicholas / Kipshidze, Nodar

    Photodiagnosis Photodyn Ther

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #716914
    Datenquelle COVID19

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