LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: In vitro evaluation of the cytotoxic and genotoxic effects of Al and Mn in ambient concentrations detected in groundwater intended for human consumption.

    Francisco, Luiza Flavia Veiga / Baldivia, Debora da Silva / Crispim, Bruno do Amaral / Baranoski, Adrivanio / Klafke, Syla Maria Farias Ferraz / Dos Santos, Edson Lucas / Oliveira, Rodrigo Juliano / Barufatti, Alexeia

    Ecotoxicology and environmental safety

    2023  Band 264, Seite(n) 115415

    Abstract: Environmental exposure to metals can induce cytotoxic and genotoxic effects in cells and affect the health of the exposed population. To investigate the effects of aluminum (Al) and manganese (Mn), we evaluated their cytogenotoxicity using peripheral ... ...

    Abstract Environmental exposure to metals can induce cytotoxic and genotoxic effects in cells and affect the health of the exposed population. To investigate the effects of aluminum (Al) and manganese (Mn), we evaluated their cytogenotoxicity using peripheral blood mononuclear cells (PBMCs) exposed to these metals at previously quantified concentrations in groundwater intended for human consumption. The cell viability, membrane integrity, nuclear division index (NDI), oxidative stress, cell death, cell cycle, and DNA damage were analyzed in PBMCs exposed to Al (0.2, 0.6, and 0.8 mg/L) and Mn (0.1, 0.3, 1.0, and 1.5 for 48 h. We found that Al induced late apoptosis; decreased cell viability, NDI, membrane integrity; and increased DNA damage. However, no significant alterations in the early apoptosis, cell cycle, and reactive oxygen species levels were observed. In contrast, exposure to Mn altered all evaluated parameters related to cytogenotoxicity. Our data show that even concentrations allowed by the Brazilian legislation for Al and Mn in groundwater intended for human consumption cause cytotoxic and genotoxic effects in PBMCs. Therefore, in view of the results found, a comprehensive approach through in vivo investigations is needed to give robustness and validity to the results obtained, thus broadening the understanding of the impacts of metals on the health of environmentally exposed people.
    Mesh-Begriff(e) Humans ; Aluminum ; Manganese/toxicity ; Leukocytes, Mononuclear ; Antineoplastic Agents ; Groundwater ; DNA Damage
    Chemische Substanzen Aluminum (CPD4NFA903) ; Manganese (42Z2K6ZL8P) ; Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2023-09-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2023.115415
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Acute Toxic and Genotoxic Effects of Aluminum and Manganese Using In Vitro Models.

    Francisco, Luiza Flavia Veiga / Baldivia, Debora da Silva / Crispim, Bruno do Amaral / Klafke, Syla Maria Farias Ferraz / Castilho, Pamella Fukuda de / Viana, Lucilene Finoto / Santos, Edson Lucas Dos / Oliveira, Kelly Mari Pires de / Barufatti, Alexeia

    Toxics

    2021  Band 9, Heft 7

    Abstract: The objective of this study was to use the same concentrations of aluminum (Al) and manganese (Mn) detected previously in groundwater above those permitted by Brazilian law and assess their cytotoxic and genotoxic effects in hamster ovary cell lines and ... ...

    Abstract The objective of this study was to use the same concentrations of aluminum (Al) and manganese (Mn) detected previously in groundwater above those permitted by Brazilian law and assess their cytotoxic and genotoxic effects in hamster ovary cell lines and their mutagenic effects through the
    Sprache Englisch
    Erscheinungsdatum 2021-06-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics9070153
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang