LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 5 von insgesamt 5

Suchoptionen

  1. Artikel ; Online: Comparative cardiac effects of antimalarial drug halofantrine with or without concomitant administration of kolanut or fluconazole in healthy volunteers.

    Adedapo, Aduragbenro DA / Ojji, Dike B / Adedapo, Kayode S / Kolade, Yetunde / Babalola, Chinedum P

    African health sciences

    2023  Band 23, Heft 1, Seite(n) 262–269

    Abstract: Background: There is rekindled interest in the cardiotoxicity of antimalarial medicines. Halofantrine is associated with QT interval prolongation. Fluconazole and kolanut alter the pharmacokinetics of halofantrine.: Objectives: The study assessed the ...

    Abstract Background: There is rekindled interest in the cardiotoxicity of antimalarial medicines. Halofantrine is associated with QT interval prolongation. Fluconazole and kolanut alter the pharmacokinetics of halofantrine.
    Objectives: The study assessed the electrocardiographic changes of concomitant administration of kolanut or fluconazole with halofantrine and the effects on the QTc interval.
    Methods: Eighteen healthy volunteers received a single oral dose of halofantrine, halofantrine with kolanut or halofantrine with fluconazole in a crossover study. Twelve lead electrocardiography (ECG) was performed to measure the PR and QT interval (QTc). Statistical analysis was with SPSS at 5% level of significance.
    Results: PR intervals were shortened by halofantrine alone and halofantrine with kolanut (169.29 28.67 to 165.29 28.007 and 172.73 29.843 to 163.00 18.336ms) but was prolonged by halofantrine with fluconazole (177.70 27.394 to 186.59 44.434ms). There was prolongation of QTc (384.76 21.727 to 394.12 21.525; 381.36 22.29 to 388.30 17.26 and 382.35 20.08 to 390.84 21.97) in all the three treatment groups at 6 hours, p>0.05. One subject on halofantrine and fluconazole had QTc >440ms. Pre-treatment PR interval (PR
    Conclusion: Concomitant intake of kolanut with halofantrine was significantly decrease cardiac effect of halofantrine.
    Mesh-Begriff(e) Humans ; Antimalarials/adverse effects ; Cross-Over Studies ; Electrocardiography ; Fluconazole/adverse effects ; Healthy Volunteers
    Chemische Substanzen Antimalarials ; Fluconazole (8VZV102JFY) ; halofantrine (Q2OS4303HZ)
    Sprache Englisch
    Erscheinungsdatum 2023-07-28
    Erscheinungsland Uganda
    Dokumenttyp Clinical Trial ; Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v23i1.28
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3851: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Konferenzbeitrag: Viruzide Wirksamkeit von Cetylpyridiniumchlorid-Lutschtabletten gegen Coronavirus und Influenzavirus

    Peiter, Tina / Goelzer, Maren / Kolade, Yetunde / Coutinho, Graca / Eggers, Maren

    2023  , Seite(n) P–03–09

    Veranstaltung/Kongress 57. Kongress für Allgemeinmedizin und Familienmedizin; Berlin; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2023
    Schlagwörter Medizin, Gesundheit
    Erscheinungsdatum 2023-09-27
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/23degam177
    Datenquelle German Medical Science

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel: Analysis of the antimalarial drug halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by high performance liquid chromatography.

    Kolade, Yetunde T / Babalola, Chinedum P / Scriba, Gerhard K E

    Journal of pharmaceutical and biomedical analysis

    2006  Band 41, Heft 1, Seite(n) 315–319

    Abstract: The determination of halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by reversed phase high-pressure liquid chromatography is described. The method involves protein precipitation of plasma samples by acetonitrile followed by ... ...

    Abstract The determination of halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by reversed phase high-pressure liquid chromatography is described. The method involves protein precipitation of plasma samples by acetonitrile followed by basification with sodium hydroxide and subsequent liquid-liquid extraction using hexane-diethyl ether (1:1, v/v). The chromatographic separation was carried out on a C-18 column with a mobile phase consisting of methanol/0.05 M KH2PO4 (78:22, v/v) containing 55 mM perchloric acid. Chlorprothixen was used as internal standard. The relative standard deviations of intraday and interday precision for both compounds were less than 7%, the relative standard deviation of the accuracy did not exceed 7.1% at concentrations of 50 and 300 ng/ml. This method is simple, rapid, sensitive and cost effective and was applied to the determination of the pharmacokinetics of halofantrine and N-desbutylhalofantrine in two healthy male volunteers after an oral administration of 500 mg halofantrine. Moreover, the influence of the frequently consumed kolanut on the pharmacokinetics of halofantrine was investigated.
    Mesh-Begriff(e) Antimalarials/analysis ; Antimalarials/chemistry ; Calibration ; Chemistry, Pharmaceutical/methods ; Chromatography, High Pressure Liquid/methods ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Models, Chemical ; Phenanthrenes/analysis ; Phenanthrenes/blood ; Phenanthrenes/metabolism ; Phenanthrenes/pharmacokinetics ; Reproducibility of Results ; Technology, Pharmaceutical/methods ; Time Factors
    Chemische Substanzen Antimalarials ; Phenanthrenes ; 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol (7K35DDV85X) ; halofantrine (Q2OS4303HZ)
    Sprache Englisch
    Erscheinungsdatum 2006-04-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2005.11.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1850: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine.

    Kolade, Yetunde T / Babalola, Chinedum P / Olaniyi, Ajibola A / Scriba, Gerhard K E

    European journal of clinical pharmacology

    2007  Band 64, Heft 1, Seite(n) 77–81

    Abstract: Objective: To study the effect of the concomitant consumption of kolanut, a caffeine-containing nut, on the pharmacokinetics of halofantrine.: Methods: A single dose of 500 mg halofantrine hydrochloride was orally administered either alone or ... ...

    Abstract Objective: To study the effect of the concomitant consumption of kolanut, a caffeine-containing nut, on the pharmacokinetics of halofantrine.
    Methods: A single dose of 500 mg halofantrine hydrochloride was orally administered either alone or concomitant with 12.5 g kolanut to 15 healthy male volunteers in a Latin-square randomized crossover design with a wash-out period of 6 weeks between treatments. Blood samples were collected and analyzed by HPLC for halofantrine and the active metabolite N-desbutylhalofantrine.
    Results: Concomitant intake of kolanut with halofantrine significantly decreased C(max) and AUC of both halofantrine and the metabolite desbutylhalofantrine, while no significant effect was observed for t (max) and t(1/2) of the compounds. In the case of halofantrine, C(max) decreased from 179 +/- 119 to 98 +/- 32 ng/ml, and the AUC was reduced from 17,450 +/- 4,611 to 11,821 +/- 4,069 ng x h/ml. C(max) of desbutylhalofantrine decreased from 124 +/- 41 to 62 +/- 23 ng/ml and the AUC from 13,341 +/- 4,749 to 7,359 +/- 3,018 ng x h/ml when kolanut was co-administered.
    Conclusions: Co-administration of halofantrine and kolanut caused a significant decrease in the plasma concentrations of halofantrine and the active metabolite desbutylhalofantrine probably during adsorption of the drug due to complex formation. This indicates that caution should be exerted when the drug is taken together with caffeine-containing nutrients.
    Mesh-Begriff(e) Administration, Oral ; Adult ; Antimalarials/pharmacokinetics ; Area Under Curve ; Caffeine/isolation & purification ; Caffeine/pharmacology ; Chromatography, High Pressure Liquid ; Cola/chemistry ; Cross-Over Studies ; Drug Interactions ; Half-Life ; Humans ; Male ; Nuts/chemistry ; Phenanthrenes/pharmacokinetics
    Chemische Substanzen Antimalarials ; Phenanthrenes ; Caffeine (3G6A5W338E) ; 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol (7K35DDV85X) ; halofantrine (Q2OS4303HZ)
    Sprache Englisch
    Erscheinungsdatum 2007-10-20
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-007-0387-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 672: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Kinetics of thermal decomposition of 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD).

    Idowu, Olakunle S / Kolawole, Abiola O / Adegoke, Olajire A / Kolade, Yetunde T / Fasanmade, Adedigbo A / Olaniyi, Ajibola A

    Journal of AOAC International

    2005  Band 88, Heft 4, Seite(n) 1108–1113

    Abstract: The kinetics of thermal decomposition of 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD), an arenediazonium ion newly developed as a derivatizing reagent for drug analysis, are described. The arenediazonium ion, in an optimized concentrated sulfuric ... ...

    Abstract The kinetics of thermal decomposition of 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD), an arenediazonium ion newly developed as a derivatizing reagent for drug analysis, are described. The arenediazonium ion, in an optimized concentrated sulfuric acid/orthophosphoric acid medium, was incubated for various time intervals at 30 degrees, 45 degrees, 55 degrees , 65 degrees , 75 degrees, and 85 degrees C. The amount of ion left after each time interval was quantified selectively by colorimetric assay at 490 nm, using mefenamic acid as a model diazo-coupling component. The rate constants for the decomposition were determined graphically. An Arrhenius plot was used to delineate the dependence of the rate constant on temperature and to predict the half-life at 25 degrees C and lower temperatures. The diazonium ion decomposed by first-order kinetics. The rate constants of decomposition, which increased progressively with temperature, were 3.18 +/- 0.41 x 10(-5), 1.19 +/- 0.07 x 10(-4), 4.87 +/- 0.15 x 10(-4), 12.88 +/- 0.73 x 10(-4), and 21.32 +/- 2.74 x 10(-4) (s(-1)) with corresponding half-lives of 363, 97.06, 23.72, 8.97, and 5.42 min at 30 degrees, 45 degrees, 55 degrees, 65 degrees, and 75 degrees C, respectively. CDNBD is highly stable in concentrated acid medium, with half-life values of about 10 h, 10 days, and 7.3 months at 25 degrees, 0 degrees, and -20 degrees C, respectively. The reagent stability profile shows that it could be readily adapted for routine applications in instrumental chemical analysis.
    Mesh-Begriff(e) Acetates/analysis ; Acetic Acid/analysis ; Calibration ; Colorimetry ; Diazonium Compounds/analysis ; Diazonium Compounds/chemistry ; Dose-Response Relationship, Drug ; Drug Stability ; Drug Storage ; Hot Temperature ; Hydroxybenzoate Ethers ; Hydroxybenzoates/analysis ; Ions ; Kinetics ; Mefenamic Acid/analysis ; Models, Chemical ; Sodium Nitrite/analysis ; Solutions ; Temperature ; Time Factors
    Chemische Substanzen 4-carboxyl-2,6-dinitrobenzenediazonium ion ; Acetates ; Diazonium Compounds ; Hydroxybenzoate Ethers ; Hydroxybenzoates ; Ions ; Solutions ; Mefenamic Acid (367589PJ2C) ; 4-anisic acid (4SB6Y7DMM3) ; ethyl acetate (76845O8NMZ) ; Sodium Nitrite (M0KG633D4F) ; Acetic Acid (Q40Q9N063P)
    Sprache Englisch
    Erscheinungsdatum 2005-03-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1229: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang