Artikel ; Online: Single-domain antibody-based protein degrader for synucleinopathies.
2024 Band 19, Heft 1, Seite(n) 44
Abstract: Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for synucleinopathies, and treatments ... ...
Abstract | Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for synucleinopathies, and treatments mainly focus on symptom management. In this study, we developed a single-domain antibody (sdAb)-based protein degrader with features designed to enhance proteasomal degradation of α-syn. This sdAb derivative targets both α-syn and Cereblon (CRBN), a substrate-receptor for the E3-ubiquitin ligase CRL4 |
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Mesh-Begriff(e) | Animals ; Synucleinopathies/metabolism ; alpha-Synuclein/metabolism ; alpha-Synuclein/immunology ; Mice ; Humans ; Single-Domain Antibodies ; Disease Models, Animal ; Brain/metabolism ; Proteasome Endopeptidase Complex/metabolism |
Chemische Substanzen | alpha-Synuclein ; Single-Domain Antibodies ; Proteasome Endopeptidase Complex (EC 3.4.25.1) |
Sprache | Englisch |
Erscheinungsdatum | 2024-05-31 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 2244557-2 |
ISSN | 1750-1326 ; 1750-1326 |
ISSN (online) | 1750-1326 |
ISSN | 1750-1326 |
DOI | 10.1186/s13024-024-00730-y |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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