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  1. Buch ; Dissertation / Habilitation: Untersuchung von Parametern der Gefäßfunktion bei Lebendnierenspendern und Lebendnierentransplantatempfängern

    Mang, Johannes / Krämer, Bernhard

    2022  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Johannes Felix Mang ; Referent: Prof. Dr. med. Bernhard Krämer
    Thema/Rubrik (Code) 617.46 ; 610
    Sprache Deutsch
    Umfang 59 Blätter, Diagramme, Illustrationen
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    HBZ-ID HT030358747
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch ; Dissertation / Habilitation: Patienten- und Transplantatüberleben nach Doppelnierentransplantation im Vergleich zu einer gematchten Kontrollgruppe

    Marinez, Julian / Krämer, Bernhard

    „Ergebnisse des Mannheimer Transplantationszentrums in der aktuellen Spendersituation mit zunehmender Zahl marginaler Organe“

    2021  

    Titelvarianten Patientenüberleben
    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Julian Marinez ; Referent: Herr Prof. Dr. med. B. Krämer
    Sprache Deutsch
    Umfang 55 Blätter, Diagramme, 30 cm
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021410254
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Buch ; Dissertation / Habilitation: Effekt von Omega-3-Fettsäuren auf die Expression der endothelialen und thrombozytären Aktivitäts- und Progressionsmarker

    Michaeli, Christoph T. / Krämer, Bernhard

    2022  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Christoph Thomas Michaeli ; Referent: Prof. Dr. med. Bernhard Krämer
    Sprache Deutsch
    Umfang 100 Blätter, Illustrationen, Diagramme, 30 cm
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2023
    HBZ-ID HT030043566
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch ; Dissertation / Habilitation: Der Einsatz von Minoxidil zur Behandlung der therapieresistenten Hypertonie bei chronischer Niereninsuffizienz

    Matenaer, Matthias / Krämer, Bernhard

    2020  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Matthias Matenaer ; Referent: Prof. Dr. med. Bernhard Krämer
    Sprache Deutsch
    Umfang 46 Blätter, Diagramme, 30 cm
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2020
    HBZ-ID HT020893723
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Artikel ; Online: Does the Expanded Controlled Evidence Now Mandate the Routine Use of Machine Perfusion in Kidney Transplantation?

    Schnuelle, Peter / Krämer, Bernhard K

    Mayo Clinic proceedings

    2023  Band 99, Heft 1, Seite(n) 22–25

    Mesh-Begriff(e) Humans ; Kidney Transplantation ; Kidney ; Perfusion ; Graft Survival
    Sprache Englisch
    Erscheinungsdatum 2023-11-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.09.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Konferenzbeitrag: Abstracts / International Meeting on Cyclooxygenase-2 and Renal Function

    Krämer, Bernhard K.

    May 26 - 27, 2000, Regensburg, Germany

    2000  

    Veranstaltung/Kongress International Meeting on Cyclooxygenase-2 and Renal Function (2000, Regensburg)
    Verfasserangabe ed. Bernhard Krämer
    Sprache Englisch
    Erscheinungsland Schweiz
    Dokumenttyp Artikel ; Konferenzbeitrag
    Anmerkung In: Kidney & blood pressure research. - ISSN 1420-4096. - 23 (2000),6, S. 405 - 413
    HBZ-ID HT012856743
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  7. Artikel ; Online: Erhöhen Antihypertensiva das Krebsrisiko?

    Krämer, Bernhard K

    MMW Fortschritte der Medizin

    2019  Band 161, Heft 13, Seite(n) 63–64

    Titelübersetzung Hypertension therapy - what is the risk of getting cancer from antihypertensive drugs?
    Mesh-Begriff(e) Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Humans ; Hypertension/drug therapy ; Neoplasms/chemically induced
    Chemische Substanzen Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents
    Sprache Deutsch
    Erscheinungsdatum 2019-07-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-019-0717-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Diagnostic accuracy of Afirma Gene Expression Classifier, Afirma Gene Sequencing Classifier, ThyroSeq v2 and ThyroSeq v3 for indeterminate (Bethesda III and IV) thyroid nodules: a meta-analysis.

    Vardarli, Irfan / Tan, Susanne / Görges, Rainer / Krämer, Bernhard K / Herrmann, Ken / Brochhausen, Christoph

    Endocrine connections

    2024  

    Abstract: Objective: The management of thyroid nodules with indeterminate cytology (ITN) is still a challenge. To evaluate the performance of commercial molecular tests for ITN, we performed this comprehensive meta-analysis.: Methods: We performed an ... ...

    Abstract Objective: The management of thyroid nodules with indeterminate cytology (ITN) is still a challenge. To evaluate the performance of commercial molecular tests for ITN, we performed this comprehensive meta-analysis.
    Methods: We performed an electronic search using PubMed/Medline, Embase and the Cochrane Library. Studies assessing the diagnostic accuracy of Afirma Gene Expression Classifier (GEC), Afirma Gene Sequencing Classifier (GSC), ThyroSeq v2 (TSv2) or ThyroSeq v3 (TSv3) in patients with ITN (only Bethesda category III or IV) were selected; Statistical analyses were performed by using Stata.
    Results: 71 samples (GEC, n=38; GSC, n=16; TSv2, n=9; TSv3, n=8) in 53 studies, involving 6,490 fine needle aspirations (FNA) with ITN cytology with molecular diagnostics (GEC, GSC, TSv2 or TSv3) were included in the study. Meta-analysis showed the following pooled estimates: sensitivity 0.95 (95% CI, 0.94-0.97), specificity 0.35 (0.28-0.43), Positive Likelihood Ratio (LR+) 1.5 (1.3-1.6), and Negative Likelihood Ratio (LR-) 0.13 (0.09-0.19), with the best performance for TSv3 (area under the ROC curve 0.95 (0.93-0.96), followed by TSv2 (0.90 (0.87-0.92)), GSC (0.86 (0.82-0.88)) and GEC (0.82 (0.78-0.85)); with the best rule-out property for GSC (LR-, 0.07 (0.02-0.19)), followed by TSv3 (0.11 (0.05-0.24)) and GEC (0.16 (0.10-0.28); with the best rule-in for TSv2 (LR+, 2,9 (1.4-4.6)), followed by GSC (1.9 (1.6-2.4)). Meta-regression analysis revealed that study design, Bethesda category, and type of molecular test were independent factors.
    Conclusions: We showed that in patients with ITN, TSv3 has the best molecular diagnostic performance, followed by TSv2, GSC, and GEC. For rule-out malignancy, GSC, and for rule-in, TSV2 is superior to other tests.
    Sprache Englisch
    Erscheinungsdatum 2024-05-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-24-0170
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Reno- and cardioprotective molecular mechanisms of SGLT2 inhibitors beyond glycemic control: from bedside to bench.

    Chen, Xin / Hocher, Carl-Friedrich / Shen, Linghong / Krämer, Bernhard K / Hocher, Berthold

    American journal of physiology. Cell physiology

    2023  Band 325, Heft 3, Seite(n) C661–C681

    Abstract: Large placebo-controlled clinical trials have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) delay the deterioration of renal function and reduce cardiovascular events in a glucose-independent manner, thereby ultimately reducing mortality ... ...

    Abstract Large placebo-controlled clinical trials have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) delay the deterioration of renal function and reduce cardiovascular events in a glucose-independent manner, thereby ultimately reducing mortality in patients with chronic kidney disease (CKD) and/or heart failure. These existing clinical data stimulated preclinical studies aiming to understand the observed clinical effects. In animal models, it was shown that the beneficial effect of SGLT2i on the tubuloglomerular feedback (TGF) improves glomerular pressure and reduces tubular workload by improving renal hemodynamics, which appears to be dependent on salt intake. High salt intake might blunt the SGLT2i effects on the TGF. Beyond the salt-dependent effects of SGLT2i on renal hemodynamics, SGLT2i inhibited several key aspects of macrophage-mediated renal inflammation and fibrosis, including inhibiting the differentiation of monocytes to macrophages, promoting the polarization of macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype, and suppressing the activation of inflammasomes and major proinflammatory factors. As macrophages are also important cells mediating atherosclerosis and myocardial remodeling after injury, the inhibitory effects of SGLT2i on macrophage differentiation and inflammatory responses may also play a role in stabilizing atherosclerotic plaques and ameliorating myocardial inflammation and fibrosis. Recent studies suggest that SGLT2i may also act directly on the Na
    Mesh-Begriff(e) Animals ; Fibrosis ; Inflammation/drug therapy ; Kidney/metabolism ; Renal Insufficiency, Chronic ; Sodium Chloride, Dietary ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemische Substanzen Sodium Chloride, Dietary ; Sodium-Glucose Transporter 2 Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2023-07-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00177.2023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Clinical and genetic diagnosis of familial hypercholesterolaemia in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health Study.

    Molnar, Stefan / Scharnagl, Hubert / Delgado, Graciela E / Krämer, Bernhard K / Laufs, Ulrich / März, Winfried / Kleber, Marcus E / Katzmann, Julius L

    European heart journal. Quality of care & clinical outcomes

    2024  

    Abstract: Aims: To investigate the prevalence of familial hypercholesterolaemia (FH) and compare the performance of clinical criteria and genetic testing in patients undergoing coronary angiography.: Methods: The prevalence of FH was determined with the Dutch ... ...

    Abstract Aims: To investigate the prevalence of familial hypercholesterolaemia (FH) and compare the performance of clinical criteria and genetic testing in patients undergoing coronary angiography.
    Methods: The prevalence of FH was determined with the Dutch Lipid Clinical Network (DLCN), US-MEDPED, Simon Broome (SB) criteria, the 'Familial Hypercholesterolaemia Case Ascertainment Tool' (FAMCAT), and a clinical algorithm. Genetic screening was conducted with a custom array from Affymetrix (CARRENAL array) harboring 944 FH mutations.
    Results: The study cohort consisted of 3267 patients (78.6% with coronary artery disease [CAD]). FH was diagnosed in 2.8%, 2.2%, 3.9%, and 7.9% using the DLCN, US-MEDPED, SB criteria, and the FAMCAT. The clinical algorithm identified the same patients as the SB criteria. Pathogenic FH mutations were found in 1.2% (1.2% in patients with CAD, 1.0% in patients without CAD). FH was more frequently diagnosed in younger patients. With genetic testing as reference, the clinical criteria achieved areas under the ROC curve (AUCs) in the range of 0.56-0.68. Using only LDL-C corrected for statin intake, an AUC of 0.68 was achieved.
    Conclusion: FH is up to fourfold more prevalent in patients undergoing coronary angiography than in contemporary cohorts representing the general population. Different clinical criteria yield substantially different diagnosis rates, overestimating the prevalence of FH compared to genetic testing. LDL-C testing alone may be sufficient to raise the suspicion of FH, which then needs to be corroborated by genetic testing.
    Sprache Englisch
    Erscheinungsdatum 2024-01-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2823451-0
    ISSN 2058-1742 ; 2058-5225
    ISSN (online) 2058-1742
    ISSN 2058-5225
    DOI 10.1093/ehjqcco/qcad075
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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