LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Krista M. Pullen"
  2. AU="Higo, Tomoya"
  3. AU="Bremadesam Raman, Lakshmi"
  4. AU="Duffner, P K"
  5. AU="Walsh, Jacinta"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: 3D RNA-scaffolded wireframe origami

    Molly F. Parsons / Matthew F. Allan / Shanshan Li / Tyson R. Shepherd / Sakul Ratanalert / Kaiming Zhang / Krista M. Pullen / Wah Chiu / Silvi Rouskin / Mark Bathe

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 14

    Abstract: Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold ... ...

    Abstract Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold messenger and ribosomal RNA into 3D polyhedral structures.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

    Matthew J. Gorman / Nita Patel / Mimi Guebre-Xabier / Alex L. Zhu / Caroline Atyeo / Krista M. Pullen / Carolin Loos / Yenny Goez-Gazi / Ricardo Carrion, Jr. / Jing-Hui Tian / Dansu Yuan / Kathryn A. Bowman / Bin Zhou / Sonia Maciejewski / Marisa E. McGrath / James Logue / Matthew B. Frieman / David Montefiori / Colin Mann /
    Sharon Schendel / Fatima Amanat / Florian Krammer / Erica Ollmann Saphire / Douglas A. Lauffenburger / Ann M. Greene / Alyse D. Portnoff / Michael J. Massare / Larry Ellingsworth / Gregory Glenn / Gale Smith / Galit Alter

    Cell Reports Medicine, Vol 2, Iss 9, Pp 100405- (2021)

    2021  

    Abstract: Summary: Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a ... ...

    Abstract Summary: Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a spectrum of antibody titers is urgently required. Thus, we profiled the humoral immune response in a cohort of non-human primates immunized with a recombinant SARS-CoV-2 spike glycoprotein (NVX-CoV2373) at two doses, administered as a single- or two-dose regimen. Both antigen dose and boosting significantly altered neutralization titers and Fc-effector profiles, driving unique vaccine-induced antibody fingerprints. Combined differences in antibody effector functions and neutralization were associated with distinct levels of protection in the upper and lower respiratory tract. Moreover, NVX-CoV2373 elicited antibodies that functionally targeted emerging SARS-CoV-2 variants. Collectively, the data presented here suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
    Schlagwörter Fc-function ; antibodies ; COVID-19 ; Fc-receptors ; correlates ; vaccination ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang