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  1. Article ; Online: Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

    Qu Deng / Ramakrishnan Natesan / Florencia Cidre-Aranaz / Shehbeel Arif / Ying Liu / Reyaz ur Rasool / Pei Wang / Erick Mitchell-Velasquez / Chandan Kanta Das / Endrit Vinca / Zvi Cramer / Patrick J. Grohar / Margaret Chou / Chandan Kumar-Sinha / Kristy Weber / T.S. Karin Eisinger-Mathason / Nicolas Grillet / Thomas Grünewald / Irfan A. Asangani

    Cell Reports, Vol 39, Iss 11, Pp 110971- (2022)

    2022  

    Abstract: Summary: Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription program ... ...

    Abstract Summary: Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription program through de novo enhancers. By integrative analysis of thousands of transcriptomes representing pan-cancer cell lines, primary cancers, metastasis, and normal tissues, we identify a 32-gene signature (ESS32 [Ewing Sarcoma Specific 32]) that stratifies EwS from pan-cancer. Among the ESS32, LOXHD1, encoding a stereociliary protein, is the most highly expressed gene through an alternative transcription start site. Deletion or silencing of EWSR1::FLI1 bound upstream de novo enhancer results in loss of the LOXHD1 short isoform, altering EWSR1::FLI1 and HIF1α pathway genes and resulting in decreased proliferation/invasion of EwS cells. These observations implicate LOXHD1 as a biomarker and a determinant of EwS metastasis and suggest new avenues for developing LOXHD1-targeted drugs or cellular therapies for this deadly disease.
    Keywords CP: Cancer ; CP: Molecular biology ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Life or limb

    Peter F M Choong / Michelle M Dowsey / Samantha Bunzli / Michelle Ghert / Ajay Puri / Robert Turcotte / Penny O'Brien / Peter Rose / Will Aston / Miguel A Ayerza / Lester Chan / Stephane Cherix / Jorge de las Heras / Davide Donati / Uwale Eyesan / Nicola Fabbri / Thomas Hilton / Oluwaseyi Kayode Idowu / Jungo Imanishi /
    Dundar Sabah / Kristy Weber

    BMJ Open, Vol 11, Iss

    an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic

    2021  Volume 9

    Keywords Medicine ; R
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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