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  1. Buch ; Online ; E-Book: Environmental Metagenomics, Water Quality and Suggested Remediation Measures of Polluted Waters

    Tyagi, Inderjeet / Kumar, Vikas / Karri, Rama Rao

    2024  

    Thema/Rubrik (Code) 572.8629
    Sprache Englisch
    Umfang 1 online resource (318 pages)
    Ausgabenhinweis 1st ed.
    Verlag Elsevier
    Erscheinungsort San Diego
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-13660-2 ; 0-443-13659-9 ; 978-0-443-13660-3 ; 978-0-443-13659-7
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online ; E-Book: Herbs for diabetes and neurological disease management

    Kumar, Vikas / Veeranjaneyulu, Addepalli

    research and advancements

    2018  

    Verfasserangabe edited by Vikas Kumar, PhD; Addepalli Veeranjaneyulu, PhD
    Schlagwörter Diabetes Mellitus / therapy ; Nervous System Diseases / therapy ; Phytotherapy / methods
    Sprache Englisch
    Umfang 1 Online-Ressource (xxii, 312 Seiten), Illustrationen, Diagramme
    Verlag Apple Academic Press
    Erscheinungsort Oakville
    Erscheinungsland Kanada
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019653859
    ISBN 978-1-351-80108-9 ; 9781315207575 ; 9781771885881 ; 1-351-80108-2 ; 1315207575 ; 1771885882
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Buch ; Online ; E-Book: Nanomedicine for Bioactives

    Rahman, Mahfoozur / Beg, Sarwar / Kumar, Vikas / Ahmad, Farhan Jalees

    Healthcare applications

    2020  

    Abstract: Nanotechnology is opening up new avenues in all scientific and technological fields. Among the novel applications, bioactives and nutraceuticals are fast-growing areas of nano research for better healthcare solutions. A variety of nanoformulations, such ... ...

    Verfasserangabe edited by Mahfoozur Rahman, Sarwar Beg, Vikas Kumar, Farhan Jalees Ahmad
    Abstract Nanotechnology is opening up new avenues in all scientific and technological fields. Among the novel applications, bioactives and nutraceuticals are fast-growing areas of nano research for better healthcare solutions. A variety of nanoformulations, such as polymeric nanoparticles, nanocapsules, nanoemulsions, transferosomes and ethosomes, liposomes, lipospheres, and lipid polymer hybrid nanoparticles have proved valuable in bioactive delivery and food materials. Further, new herbal drugs and nutraceuticals are reported to have remarkable advantages over conventional formulations of plant actives and extracts, including enhanced solubility, bioavailability, multiple drug delivery, greater stability, sustained delivery, improved tissue macrophage distribution, protection from toxicity, enhancement of pharmacological activity and protection from physical and chemical degradation. This book focuses on the advanced nanomaterials that are utilized for the encapsulation of nutrients/vitamin/phytoconstituents, as well as their other healthcare benefits. .
    Schlagwörter Pharmaceutical technology ; Medicinal chemistry ; Nanochemistry ; Biomaterials ; Nanotechnology ; Pharmaceutical Sciences/Technology ; Medicinal Chemistry ; Nanotecnologia ; Compostos bioactius ; Salut
    Thema/Rubrik (Code) 363.7288
    Sprache Englisch
    Umfang 1 online resource (XIII, 486 p. 132 illus.)
    Ausgabenhinweis 1st ed. 2020.
    Verlag Springer Singapore ; Imprint: Springer
    Erscheinungsort Singapore
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-1664-2 ; 981-15-1663-4 ; 978-981-15-1664-1 ; 978-981-15-1663-4
    DOI 10.1007/978-981-15-1664-1
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  4. Buch: Microbial nanotechnology

    Kumar, Vikas / Singh, Manoj

    advances in agriculture, industry and health sectors

    2022  

    Verfasserangabe edited by Vikas Kumar and Manoj Singh
    Mesh-Begriff(e) Nanostructures/microbiology ; Nanotechnology
    Schlagwörter Nanobiotechnology. ; Nanotechnology. ; Nanobiotechnology
    Sprache Englisch
    Umfang vi, 246 pages :, illustrations (some color) ;, 24 cm
    Verlag De Gruyter
    Erscheinungsort Berlin ; Boston
    Dokumenttyp Buch
    ISBN 9783110754391 ; 3110754398 ; 9783110754476 ; 9783110754544 ; 3110754398 ; 9783110754391 ; 3110754479 ; 3110754541
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel: Whole-genome sequencing of the blue whale and other rorquals finds signatures for introgressive gene flow

    Lammers, Fritjof / Kumar, Vikas / Nilsson Janke, Maria / Janke, Axel

    Science advances, 4(4):eaap9873

    2018  

    Abstract: Reconstructing the evolution of baleen whales (Mysticeti) has been problematic because morphological and genetic analyses have produced different scenarios. This might be caused by genomic admixture that may have taken place among some rorquals. We ... ...

    Körperschaft Senckenberg Biodiversität und Klima Forschungszentrum
    Abstract Reconstructing the evolution of baleen whales (Mysticeti) has been problematic because morphological and genetic analyses have produced different scenarios. This might be caused by genomic admixture that may have taken place among some rorquals. We present the genomes of six whales, including the blue whale (Balaenoptera musculus), to reconstruct a species tree of baleen whales and to identify phylogenetic conflicts. Evolutionary multilocus analyses of 34,192 genome fragments reveal a fast radiation of rorquals at 10.5 to 7.5 million years ago coinciding with oceanic circulation shifts. The evolutionarily enigmatic gray whale (Eschrichtius robustus) is placed among rorquals, and the blue whale genome shows a high degree of heterozygosity. The nearly equal frequency of conflicting gene trees suggests that speciation of rorqual evolution occurred under gene flow, which is best depicted by evolutionary networks. Especially in marine environments, sympatric speciation might be common; our results raise questions about how genetic divergence can be established.
    Sprache Englisch
    Dokumenttyp Artikel
    Datenquelle Fachrepositorium Lebenswissenschaften

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  6. Artikel: Protecting the spinal cord during thoracic endovascular aortic repair-who should place the spinal drain?

    Foley, Edward D / Kumar, Vikas

    Journal of spine surgery (Hong Kong)

    2023  Band 9, Heft 2, Seite(n) 186–190

    Abstract: A well-placed and functioning lumbar spinal drain, for spinal cord protection, is an important aspect of the perioperative care of patients undergoing thoracic endovascular aortic repair (TEVAR) procedures. Spinal cord injury (SCI) is a devastating ... ...

    Abstract A well-placed and functioning lumbar spinal drain, for spinal cord protection, is an important aspect of the perioperative care of patients undergoing thoracic endovascular aortic repair (TEVAR) procedures. Spinal cord injury (SCI) is a devastating complication of TEVAR procedures and is most often associated with Crawford type 2 repairs. Current evidence-based guidelines for the surgical management of patients with thoracic aortic disease include the role of lumbar spine catheter placement and drainage of cerebrospinal fluid (CSF) intraoperatively as part of a strategy to prevent spinal cord ischemia. More often than not, the procedure of lumbar spinal drain placement, using a standard blind technique, and subsequent drain management is the responsibility of the anesthesiologist. However, institutional protocols are inconsistent, and, failure to successfully place the lumbar spinal drain pre-operatively in the operating room, in clinical situations such as patients with poor anatomical landmarks or prior back surgery, presents a clinical dilemma and impacts spinal cord protection during TEVAR. Although a relatively safe procedure, potential complications of lumbar spine catheter placement range from a self-limiting headache to hemorrhage and permanent neurological injury. Spinal drain placement with image-guided fluoroscopy by interventional radiology should be considered in the preoperative assessment and planning and is an alternative to conventional, blind lumbar drain insertion.
    Sprache Englisch
    Erscheinungsdatum 2023-05-30
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2874556-5
    ISSN 2414-4630 ; 2414-469X
    ISSN (online) 2414-4630
    ISSN 2414-469X
    DOI 10.21037/jss-22-116
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The Role of "Physiologically Based Pharmacokinetic Model (PBPK)" New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment.

    Deepika, Deepika / Kumar, Vikas

    International journal of environmental research and public health

    2023  Band 20, Heft 4

    Abstract: Physiologically Based Pharmacokinetic (PBPK) models are mechanistic tools generally employed in the pharmaceutical industry and environmental health risk assessment. These models are recognized by regulatory authorities for predicting organ concentration- ...

    Abstract Physiologically Based Pharmacokinetic (PBPK) models are mechanistic tools generally employed in the pharmaceutical industry and environmental health risk assessment. These models are recognized by regulatory authorities for predicting organ concentration-time profiles, pharmacokinetics and daily intake dose of xenobiotics. The extension of PBPK models to capture sensitive populations such as pediatric, geriatric, pregnant females, fetus, etc., and diseased populations such as those with renal impairment, liver cirrhosis, etc., is a must. However, the current modelling practices and existing models are not mature enough to confidently predict the risk in these populations. A multidisciplinary collaboration between clinicians, experimental and modeler scientist is vital to improve the physiology and calculation of biochemical parameters for integrating knowledge and refining existing PBPK models. Specific PBPK covering compartments such as cerebrospinal fluid and the hippocampus are required to gain mechanistic understanding about xenobiotic disposition in these sub-parts. The PBPK model assists in building quantitative adverse outcome pathways (qAOPs) for several endpoints such as developmental neurotoxicity (DNT), hepatotoxicity and cardiotoxicity. Machine learning algorithms can predict physicochemical parameters required to develop in silico models where experimental data are unavailable. Integrating machine learning with PBPK carries the potential to revolutionize the field of drug discovery and development and environmental risk. Overall, this review tried to summarize the recent developments in the in-silico models, building of qAOPs and use of machine learning for improving existing models, along with a regulatory perspective. This review can act as a guide for toxicologists who wish to build their careers in kinetic modeling.
    Mesh-Begriff(e) Humans ; Child ; Pregnancy ; Female ; Aged ; Models, Biological ; Computer Simulation ; Drug-Related Side Effects and Adverse Reactions ; Risk Assessment ; Xenobiotics
    Chemische Substanzen Xenobiotics
    Sprache Englisch
    Erscheinungsdatum 2023-02-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20043473
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Navigating the Antiretroviral Therapy Switch Conundrum: Unveiling the Dilemma of Drug Resistance and Disease Progression in HIV/AIDS.

    Sharma, Ankita / Vardhan, Gyan / Dhamija, Puneet / Kumar, Vikas

    Cureus

    2024  Band 16, Heft 3, Seite(n) e56441

    Abstract: There is a need to establish consensus for harmonization in antiretroviral (ARV) therapy (ART) switch treatment strategy and address the dilemma that exists in terms of subpar immune response to therapy or an immunologic deterioration while on therapy. ... ...

    Abstract There is a need to establish consensus for harmonization in antiretroviral (ARV) therapy (ART) switch treatment strategy and address the dilemma that exists in terms of subpar immune response to therapy or an immunologic deterioration while on therapy. The purpose of this review is to identify the factors that contribute to ARV treatment failure, such as insufficient dosage, drug interactions, poor adherence, drug resistance, and poor medication absorption. It is crucial to adopt a more efficient strategy to address this challenging dilemma. After ARV treatment failure, the aim of therapy is virologic suppression, which targets plasma viral load below the limits of detection as assessed by very sensitive tests with lower limits of quantification of 20 to 75 RNA copies/ml. The therapeutic objectives when complete virologic suppression is not possible, should be to maintain or restore immunologic function, stop the progression of the clinical illness, and minimize the emergence of new drug resistance that could further restrict the options for ARV drugs. Treatment history and drug-resistance testing, including the findings of previous and ongoing resistance tests, should be considered while selecting ARV regimens. Hence, the treatment approach post-ARV failure can be personalized based on clinical, immunologic, virologic, or as a mix of the three domains on a case-to-case basis. The evaluation of projected ARV activity should be based on treatment history and previous resistance test findings.
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56441
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Integrated alternative approaches to select feed-efficient rainbow trout families to enhance the plant protein utilization.

    Kajbaf, Kimia / Overturf, Ken / Kumar, Vikas

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 3869

    Abstract: Improving feed utilization efficiency is a challenge in aquaculture. Therefore, we developed an indirect benchmark to use in selecting trout for improved efficiency of feed utilization on plant protein (soy)-based diets, with the long-term goal of ... ...

    Abstract Improving feed utilization efficiency is a challenge in aquaculture. Therefore, we developed an indirect benchmark to use in selecting trout for improved efficiency of feed utilization on plant protein (soy)-based diets, with the long-term goal of reducing the cost of commercial trout production. We used a four-part integrative approach to identify feed efficient individuals among 1595 fish coming from 12 genetically selected families by establishing the phenotypic relationship between feed conversion ratio (FCR) and body weight variations using compensatory feeding regimes. Additionally, we examined the nutritional composition of fish filet for each efficiency phenotype during the compensatory regimen. Our findings showed that the fish with the lowest weight loss during a feed deprivation period and the highest weight gain during the refeeding period (FD-/RF +) demonstrated the lowest FCR (FCR = 0.99) and consisted of individuals from several lines. This finding confirms the possibility of improving feed efficiency in mixed lines. Although feeding period has an effect on nutritional composition of fillet, such selection criteria did not show an effect on groups. Overall, successful selection for the improvement of feed efficiency will have a broad application to commercial fish selective breeding programs, leading to increased aquaculture sustainability in the long run.
    Mesh-Begriff(e) Humans ; Animals ; Oncorhynchus mykiss/genetics ; Plant Proteins/genetics ; Diet ; Selective Breeding ; Body Weight/genetics ; Animal Feed/analysis
    Chemische Substanzen Plant Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54218-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Alteration of haematological and biochemical biomarkers after sub-lethal chronic malathion (Elathion®) intoxication in freshwater fish, Labeo rohita (Hamilton, 1822).

    Das, Basanta Kumar / Nayak, Kausalya Kumari / Kumar, Vikas

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

    2024  Band 277, Seite(n) 109844

    Abstract: The present investigation aimed to evaluate the long-term effects of malathion (Elathion®) at two sub-lethal concentrations (0.36 and 1.84 ... ...

    Abstract The present investigation aimed to evaluate the long-term effects of malathion (Elathion®) at two sub-lethal concentrations (0.36 and 1.84 mgL
    Mesh-Begriff(e) Animals ; Humans ; Malathion/toxicity ; Cyprinidae/metabolism ; Lethal Dose 50 ; Fresh Water ; Biomarkers/metabolism
    Chemische Substanzen Malathion (U5N7SU872W) ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 189285-x
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    DOI 10.1016/j.cbpc.2024.109844
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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