Artikel ; Online: Association between urinary C-megalin levels and progressive kidney dysfunction: a cohort study based on the diabetes distress and care registry at Tenri (DDCRT 24).
2023 Band 60, Heft 12, Seite(n) 1643–1650
Abstract: Aims: The aim of this cohort study was to evaluate the association between urinary levels of C-megalin, a full-length form of megalin, and kidney dysfunction progression and its dependence on the urinary albumin-creatinine ratio (UACR) in individuals ... ...
Abstract | Aims: The aim of this cohort study was to evaluate the association between urinary levels of C-megalin, a full-length form of megalin, and kidney dysfunction progression and its dependence on the urinary albumin-creatinine ratio (UACR) in individuals with diabetes. Methods: We enrolled 1,547 individuals with diabetes who visited the ambulatory clinic at Tenri Hospital, a regional tertiary-care hospital in Tenri City, Nara Prefecture, Japan, with an estimated glomerular filtration (eGFR) of ≥ 30 mL/min/1.73 m Results: Urinary C-megalin level was not associated with ≥ 40% eGFR decline in an age-, sex-, eGFR-, systolic blood pressure-, hemoglobin-, and UACR-adjusted model in the 1,547 patients enrolled in the study. However, urinary C-megalin levels were associated with a ≥ 40% decline in eGFR when accounting for the relationship between urinary C-megalin levels and UACR in the model. This association was UACR-dependent. Conclusions: High urinary C-megalin levels were associated with progressive kidney dysfunction in individuals with diabetes, and this association was attenuated by high UACRs. |
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Mesh-Begriff(e) | Humans ; Cohort Studies ; Low Density Lipoprotein Receptor-Related Protein-2 ; Diabetes Mellitus, Type 2/complications ; Kidney ; Registries ; Glomerular Filtration Rate ; Albuminuria/etiology ; Albuminuria/complications |
Chemische Substanzen | Low Density Lipoprotein Receptor-Related Protein-2 |
Sprache | Englisch |
Erscheinungsdatum | 2023-07-13 |
Erscheinungsland | Germany |
Dokumenttyp | Journal Article |
ZDB-ID | 1097676-0 |
ISSN | 1432-5233 ; 0940-5429 |
ISSN (online) | 1432-5233 |
ISSN | 0940-5429 |
DOI | 10.1007/s00592-023-02144-6 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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