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  1. Artikel: Functional dissection of parabrachial substrates in processing nociceptive information.

    Ke, Jin / Lu, Wei-Cheng / Jing, Hai-Yang / Qian, Shen / Moon, Sun-Wook / Cui, Guang-Fu / Qian, Wei-Xin / Che, Xiao-Jing / Zhang, Qian / Lai, Shi-Shi / Zhang, Ling / Zhu, Ying-Jie / Xie, Jing-Dun / Huang, Tian-Wen

    Zoological research

    2024  Band 45, Heft 3, Seite(n) 633–647

    Abstract: Painful stimuli elicit first-line reflexive defensive reactions and, in many cases, also evoke second-line recuperative behaviors, the latter of which reflects the sensing of tissue damage and the alleviation of suffering. The lateral parabrachial ... ...

    Abstract Painful stimuli elicit first-line reflexive defensive reactions and, in many cases, also evoke second-line recuperative behaviors, the latter of which reflects the sensing of tissue damage and the alleviation of suffering. The lateral parabrachial nucleus (lPBN), composed of external- (elPBN), dorsal- (dlPBN), and central/superior-subnuclei (jointly referred to as slPBN), receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity disruption. However, the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain unclear. In this study, we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor (
    Mesh-Begriff(e) Animals ; Parabrachial Nucleus/physiology ; Mice ; Nociception/physiology ; Neurons/physiology ; Pain/physiopathology ; Male ; Behavior, Animal/physiology
    Sprache Englisch
    Erscheinungsdatum 2024-05-20
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2023.412
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus.

    Jiang, Ming / Yang, Lifen / Chen, Zhuang-Gui / Lai, Shi-Shi / Zheng, Jun / Peng, Bo

    Microbial biotechnology

    2020  Band 13, Heft 4, Seite(n) 1213–1227

    Abstract: Understanding the interplay between bacterial fitness, antibiotic resistance, host immunity and host metabolism could guide treatment and improve immunity against antibiotic-resistant pathogens. The acquisition of levofloxacin (Lev) resistance affects ... ...

    Abstract Understanding the interplay between bacterial fitness, antibiotic resistance, host immunity and host metabolism could guide treatment and improve immunity against antibiotic-resistant pathogens. The acquisition of levofloxacin (Lev) resistance affects the fitness of Vibrio alginolyticus in vitro and in vivo. Lev-resistant (Lev-R) V. alginolyticus exhibits slow growth, reduced pathogenicity and greater resistance to killing by the host, Danio rerio (zebrafish), than Lev-sensitive (Lev-S) V. alginolyticus, suggesting that Lev-R V. alginolyticus triggers a weaker innate immune response in D. rerio than Lev-S V. alginolyticus. Differences were detected in the metabolome of D. rerio infected with Lev-S or Lev-R V. alginolyticus. Maltose, a crucial metabolite, is significantly downregulated in D. rerio infected with Lev-R V. alginolyticus, and exogenous maltose enhances the immune response of D. rerio to Lev-R V. alginolyticus, leading to better clearance of the infection. Furthermore, we demonstrate that exogenous maltose stimulates the host production of lysozyme and its binding to Lev-R V. alginolyticus, which depends on bacterial membrane potential. We suggest that exogenous exposure to crucial metabolites could be an effective strategy for treating and/or managing infections with antibiotic-resistant bacteria.
    Mesh-Begriff(e) Animals ; Fish Diseases ; Immunity, Innate ; Levofloxacin ; Maltose ; Vibrio Infections ; Vibrio alginolyticus ; Zebrafish
    Chemische Substanzen Maltose (69-79-4) ; Levofloxacin (6GNT3Y5LMF)
    Sprache Englisch
    Erscheinungsdatum 2020-05-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2406063-X
    ISSN 1751-7915 ; 1751-7915
    ISSN (online) 1751-7915
    ISSN 1751-7915
    DOI 10.1111/1751-7915.13582
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Na

    Jiang, Ming / Kuang, Su-Fang / Lai, Shi-Shi / Zhang, Song / Yang, Jun / Peng, Bo / Peng, Xuan-Xian / Chen, Zhuang-Gui / Li, Hui

    mBio

    2020  Band 11, Heft 6

    Abstract: Sodium-translocating NADH:quinone oxidoreductase ( ... ...

    Abstract Sodium-translocating NADH:quinone oxidoreductase (Na
    Mesh-Begriff(e) Alanine/metabolism ; Aminoglycosides/pharmacology ; Anti-Bacterial Agents/analysis ; Anti-Bacterial Agents/pharmacology ; Aspartic Acid/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biological Transport ; Drug Resistance, Bacterial ; Gentamicins/analysis ; Gentamicins/pharmacology ; Glutamic Acid/metabolism ; Membrane Potentials/drug effects ; Metabolome ; Metabolomics ; Oxidation-Reduction ; Sequence Deletion ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism ; Vibrio alginolyticus/drug effects ; Vibrio alginolyticus/genetics ; Vibrio alginolyticus/growth & development
    Chemische Substanzen Aminoglycosides ; Anti-Bacterial Agents ; Bacterial Proteins ; Gentamicins ; Aspartic Acid (30KYC7MIAI) ; Glutamic Acid (3KX376GY7L) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Alanine (OF5P57N2ZX)
    Sprache Englisch
    Erscheinungsdatum 2020-11-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02086-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis.

    Ye, Jin-Zhou / Su, Yu-Bin / Lin, Xiang-Min / Lai, Shi-Shi / Li, Wan-Xin / Ali, Farman / Zheng, Jun / Peng, Bo

    Frontiers in microbiology

    2018  Band 9, Seite(n) 29

    Abstract: Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic- ... ...

    Abstract Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic-resistant bacteria, whose action is through up-regulating TCA cycle, increasing proton motive force and enhancing antibiotic uptake. Despite the fact that alanine altered several metabolic pathways, other mechanisms could be potentially involved in alanine-mediated kanamycin killing of bacteria which remains to be explored. In the present study, we adopted proteomic approach to analyze the proteome changes induced by exogenous alanine. Our results revealed that the expression of three outer membrane proteins was altered and the deletion of
    Sprache Englisch
    Erscheinungsdatum 2018-01-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.00029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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