Artikel ; Online: Air Pollution Drives Macrophage Senescence through a Phagolysosome-15-Lipoxygenase Pathway.
ImmunoHorizons
2024 Band 8, Heft 4, Seite(n) 307–316
Abstract: Urban particulate matter (PM; uPM) poses significant health risks, particularly to the respiratory system. Fine particles, such as PM2.5, can penetrate deep into the lungs and exacerbate a range of health problems, including emphysema, asthma, and lung ... ...
Abstract | Urban particulate matter (PM; uPM) poses significant health risks, particularly to the respiratory system. Fine particles, such as PM2.5, can penetrate deep into the lungs and exacerbate a range of health problems, including emphysema, asthma, and lung cancer. PM exposure is also linked to extrapulmonary disorders such as heart and neurodegenerative diseases. Moreover, prolonged exposure to elevated PM levels can reduce overall life expectancy. Senescence is a dysfunctional cell state typically associated with age but can also be precipitated by environmental stressors. This study aimed to determine whether uPM could drive senescence in macrophages, an essential cell type involved in particulate phagocytosis-mediated clearance. Although it is known that uPM exposure impairs immune function, this deficit is multifaceted and incompletely understood, partly because of the use of particulates such as diesel exhaust particles as a surrogate for true uPM. uPM was collected from several locations in the United States, including Baltimore, Houston, and Phoenix. Bone marrow-derived macrophages were stimulated with uPM or reference particulates (e.g., diesel exhaust particles) to assess senescence-related parameters. We report that uPM-exposed bone marrow-derived macrophages adopt a senescent phenotype characterized by increased IL-1α secretion, senescence-associated β-galactosidase activity, and diminished proliferation. Exposure to allergens failed to elicit such a response, supporting a distinction between different types of environmental exposure. uPM-induced senescence was independent of key macrophage activation pathways, specifically inflammasome and scavenger receptors. However, inhibition of the phagolysosome pathway abrogated senescence markers, supporting this phenotype's attribution to uPM phagocytosis. These data suggest that uPM exposure leads to macrophage senescence, which may contribute to immunopathology. |
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Mesh-Begriff(e) | Arachidonate 15-Lipoxygenase ; Vehicle Emissions ; Air Pollution ; Macrophages ; Phagosomes ; Dust |
Chemische Substanzen | Arachidonate 15-Lipoxygenase (EC 1.13.11.33) ; Vehicle Emissions ; Dust |
Sprache | Englisch |
Erscheinungsdatum | 2024-04-14 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ISSN | 2573-7732 |
ISSN (online) | 2573-7732 |
DOI | 10.4049/immunohorizons.2300096 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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