Artikel: The haematological puzzle of Hb J Cape Town is partly solved.
British journal of haematology
1986 Band 63, Heft 2, Seite(n) 363–367
Abstract: Molecular studies have shown that the mutation giving rise to Hb J Cape Town (alpha 92 arg----gln) is situated on a chromosome from which the other alpha-globin gene has been deleted. The -alpha 3.7 deletion has resulted from crossing-over within segment ...
| Abstract | Molecular studies have shown that the mutation giving rise to Hb J Cape Town (alpha 92 arg----gln) is situated on a chromosome from which the other alpha-globin gene has been deleted. The -alpha 3.7 deletion has resulted from crossing-over within segment I of the Z region of homology. There appears to be an unusually high proportion of the variant haemoglobin in heterozygotes which cannot be explained by gene dosage alone. |
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| Mesh-Begriff(e) | Chromosome Deletion ; Globins/genetics ; Hemoglobin A2/analysis ; Hemoglobin J/analysis ; Hemoglobin J/genetics ; Hemoglobins, Abnormal/genetics ; Heterozygote ; Humans ; Pedigree | |||||
| Chemische Substanzen | Hemoglobins, Abnormal ; Hemoglobin J (58128-48-6) ; Globins (9004-22-2) ; Hemoglobin A2 (9034-53-1) | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 1986-06 | |||||
| Erscheinungsland | England | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 80077-6 | |||||
| ISSN | 1365-2141 ; 0007-1048 | |||||
| ISSN (online) | 1365-2141 | |||||
| ISSN | 0007-1048 | |||||
| DOI | 10.1111/j.1365-2141.1986.tb05561.x | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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