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  1. Konferenzbeitrag ; Online: Antibiotic resistance in aquatic environments

    Jampani, Mahesh / Mateo-Sagasta, Javier / Langan, Simon

    priorities and knowledge for water quality modelling

    2023  

    Schlagwörter resistance to antibiotics ; aquatic environment ; water quality ; modelling ; bacteria ; pollution ; transformation ; wastewater ; health hazards
    Sprache Englisch
    Erscheinungsdatum 2023-12-11T05:37:33Z
    Erscheinungsland fr
    Dokumenttyp Konferenzbeitrag ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Konferenzbeitrag ; Online: Antibiotic resistance in aquatic environments

    Jampani, Mahesh / Mateo-Sagasta, Javier / Langan, Simon

    priorities and knowledge for water quality modelling [Abstract only].

    2023  

    Schlagwörter resistance to antibiotics ; antibiotic resistance genes ; bacteria ; water quality ; modelling ; frameworks ; aquatic environment ; public health ; health hazards
    Sprache Englisch
    Erscheinungsdatum 2023-12-11T09:25:16Z
    Erscheinungsland fr
    Dokumenttyp Konferenzbeitrag ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Using the RECORD guidelines to improve transparent reporting of studies based on routinely collected data.

    Harron, K / Benchimol, E / Langan, S

    International journal of population data science

    2018  Band 3, Heft 1, Seite(n) 2

    Abstract: Transparent reporting of routinely-collected data studies is key to producing valid and reliable research that can inform decisions about patient care and health systems. This article discusses some of the unique challenges in using these data sources, ... ...

    Abstract Transparent reporting of routinely-collected data studies is key to producing valid and reliable research that can inform decisions about patient care and health systems. This article discusses some of the unique challenges in using these data sources, and explains how the REporting of studies Conducted using Observational Routinely-collected Data (RECORD) guidelines were developed to help researchers and journals to maintain a high level of quality in reporting of healthcare studies using routinely-collected data.
    Sprache Englisch
    Erscheinungsdatum 2018-01-24
    Erscheinungsland Wales
    Dokumenttyp Journal Article
    ISSN 2399-4908
    ISSN (online) 2399-4908
    DOI 10.23889/ijpds.v3i1.419
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Cementless versus Cemented Total Knee Arthroplasty Using the Same Implant Design: A Mean 5-Year Follow-up Study.

    Miller, Adam J / Nadar, Arun C / Granade, Charles M / Smith, Langan S / Yakkanti, Madhusudhan R / Malkani, Arthur L

    The journal of knee surgery

    2024  

    Abstract: Cementless implant use continues to increase primarily due to increased numbers of younger and obese patients opting for primary total knee arthroplasty (TKA). Given the increased use of cementless implants, the purpose of this study was to evaluate the ... ...

    Abstract Cementless implant use continues to increase primarily due to increased numbers of younger and obese patients opting for primary total knee arthroplasty (TKA). Given the increased use of cementless implants, the purpose of this study was to evaluate the midterm clinical performance of cementless TKA using a highly porous tibial baseplate compared with its cemented counterpart of the same system. We conducted a retrospective case-control study of 400 patients undergoing primary TKA that included 200 patients with cementless components matched for age and body mass index (BMI) to 200 patients with cemented implants of the same implant design with a 5-year follow-up. We evaluated clinical results, complications, revisions, and overall survivorship between the cohorts. Statistical analysis was performed using student
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2075354-8
    ISSN 1938-2480 ; 1538-8506 ; 0899-7403
    ISSN (online) 1938-2480
    ISSN 1538-8506 ; 0899-7403
    DOI 10.1055/s-0044-1785192
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Results of Primary Total Knee Arthroplasty in Patients on Chronic Psychotropic Medications.

    Smith, Nolan S / Abhari, Sarag / Smith, Langan S / Altman, Kyle M / Yakkanti, Madhusudhan R / Malkani, Arthur L

    The Journal of arthroplasty

    2024  

    Abstract: Background: Psychotropic medications are commonly used to treat several mental health conditions. The aim of this study was to determine the impact of psychotropic medications in patients undergoing primary total knee arthroplasty (TKA) with respect to ... ...

    Abstract Background: Psychotropic medications are commonly used to treat several mental health conditions. The aim of this study was to determine the impact of psychotropic medications in patients undergoing primary total knee arthroplasty (TKA) with respect to postoperative opioid use, complications, patient-reported outcome measures, and satisfaction.
    Methods: This is a retrospective cohort study of 514 consecutive patients undergoing primary TKA. There were 120 patients (23.3%) who were excluded due to preoperative opioid usage. The remaining 394 patients had a minimum 1-year follow-up. Of those, 133 (34%) were on psychotropic medications preoperatively and were compared to the remaining 261 (66%) patients who were not on psychotropics. Clinical data, satisfaction, Knee Society (KS) scores, Western Ontario McMaster Universities Arthritis Index, Patient-Reported Outcomes Measurement Index Score, Forgotten Joint Scores, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, postoperative opioid medication usage, and complications were compared.
    Results: The study cohort (psychotropic medications) had significantly lower postoperative KS Function, KS Knee, Forgotten Joint Scores, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, Western Ontario McMaster Universities Arthritis Index, and Patient-Reported Outcomes Measurement Index Score compared to the control group. The study group had a lower overall satisfaction score (Likert scale 1 to 5) and a lower percentage of patients either satisfied or very satisfied (4.55 versus 4.79, P < .001; 92.0 versus 97.24%, P = .03, respectively). Postoperative opioid usage was significantly greater in the study group at both 6.4 weeks (range, 4 to 8) and 12-month follow-up (52.76 versus 13.33%, P < .001; 5.51 versus 0.39%, P = .002, respectively). There were no differences in complications and revisions between the groups.
    Conclusions: Patients on psychotropic medications should be educated on the risk of increased opioid consumption, diminished satisfaction, and patient-reported outcome measures following primary TKA. Given the large number of patients on psychotropic medications undergoing TKA, additional studies are needed to further improve clinical outcomes in this group.
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2024.02.037
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Konferenzbeitrag ; Online: Lessons from the results of smallholder irrigation technologies (IWMI)

    Langan, Simon

    2015  

    Abstract: Proceedings of the Launching Workshop of the Agricultural Water Management Platform, Addis Ababa, Ethiopia, 15-16 January 2015. Colombo, Sri Lanka: International Water Management Institute (IWMI). ...

    Abstract Proceedings of the Launching Workshop of the Agricultural Water Management Platform, Addis Ababa, Ethiopia, 15-16 January 2015. Colombo, Sri Lanka: International Water Management Institute (IWMI).
    Schlagwörter Irrigation methods ; Technology ; Smallholders ; Farmers ; Pumps ; Productivity Analysis ; Research and Development/Tech Change/Emerging Technologies
    Sprache Englisch
    Erscheinungsland us
    Dokumenttyp Konferenzbeitrag ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Ask Me about My Pearls: Burn Care, Ethics, and Creative Writing.

    Reilly, Debra Ann / Langan, Steve

    AMA journal of ethics

    2018  Band 20, Heft 1, Seite(n) 589–594

    Abstract: Channeling feelings into the written word rather than the scalpel was at the heart of the creative writing challenge that the first author (DR) accepted when she joined the Seven Doctors Project at the University of Nebraska Medical Center in 2008. ... ...

    Abstract Channeling feelings into the written word rather than the scalpel was at the heart of the creative writing challenge that the first author (DR) accepted when she joined the Seven Doctors Project at the University of Nebraska Medical Center in 2008. Burnout has become recognized as a factor undermining physicians' quality of life, and the practice of creative writing helps mitigate stress and sustain a successful practice. When physicians partner with and are mentored by a seasoned creative writer, creative writing can serve as an exercise in ethical reflection, which is particularly valuable at mid-career; this is the subject of the following dialogue between one physician writer and the facilitator of the Seven Doctors Project creative writing class.
    Mesh-Begriff(e) Burnout, Professional/prevention & control ; Burns/therapy ; Creativity ; Curriculum ; Emotions ; Ethics, Medical ; Hospitals, University ; Humanities ; Humans ; Mentors ; Nebraska ; Occupational Stress/psychology ; Occupational Stress/therapy ; Physicians/psychology ; Quality of Life ; Thinking ; Writing
    Sprache Englisch
    Erscheinungsdatum 2018-06-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2376-6980
    ISSN (online) 2376-6980
    DOI 10.1001/journalofethics.2018.20.6.pnar1-1806
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Distribution of vitamin D status in the UK: a cross-sectional analysis of UK Biobank.

    Lin, Liang-Yu / Smeeth, Liam / Langan, Sinead / Warren-Gash, Charlotte

    BMJ open

    2021  Band 11, Heft 1, Seite(n) e038503

    Abstract: Objective: No recent large studies have described the distribution of vitamin D status in the UK. Understanding the epidemiology of vitamin D deficiency is important to inform targeted public health recommendations. This study aimed to investigate the ... ...

    Abstract Objective: No recent large studies have described the distribution of vitamin D status in the UK. Understanding the epidemiology of vitamin D deficiency is important to inform targeted public health recommendations. This study aimed to investigate the distribution of factors associated with serum vitamin D status in a large national cohort.
    Design: A cross-sectional study.
    Setting: The UK Biobank, a prospective cohort study following the health and well-being of middle-aged and older adults recruited between 2006 and 2010.
    Participants: A total of 449 943 participants aged 40-69 years with measured serum vitamin D status were eligible for the analysis. Participants completed a questionnaire about sex, age, ethnic background, vitamin D supplementation, smoking, drinking and socioeconomic status.
    Primary and secondary outcome measures: We investigated the distribution of serum vitamin D status and the association between demographic factors and vitamin D deficiency or insufficiency. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D level <25 nmol/L. Multivariable logistic regression was used to assess the association between demographic factors and vitamin D status.
    Results: Asian (n=4297/8000, 53.7%) and black (n=2459/7046, 34.9%) participants had a higher proportion of vitamin D deficiency than white participants (n=50 920/422 907, 12%). During spring and winter, the proportion of vitamin D deficiency was higher across the UK and higher in the north than in the south. Male sex, abnormal body mass index, non-white ethnic backgrounds, smoking and being more socioeconomically deprived were associated with higher odds of vitamin D deficiency. Increasing age, taking vitamin D supplements and drinking alcohol were associated with lower odds of deficiency.
    Conclusions: Vitamin D status varied among different ethnic groups and by season and geographical area within the UK. Taking supplements was associated with a lower risk of vitamin D deficiency. These findings support the vitamin D supplementation recommendations of Public Health England.
    Mesh-Begriff(e) Adult ; Aged ; Biological Specimen Banks ; Cross-Sectional Studies ; Dietary Supplements ; England ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Seasons ; United Kingdom/epidemiology ; Vitamin D ; Vitamin D Deficiency/epidemiology
    Chemische Substanzen Vitamin D (1406-16-2)
    Sprache Englisch
    Erscheinungsdatum 2021-01-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-038503
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Perceived psychological stress and risk of herpes zoster: a nationwide population-based cohort study.

    Schmidt, S A J / Sørensen, H T / Langan, S M / Vestergaard, M

    The British journal of dermatology

    2021  Band 185, Heft 1, Seite(n) 130–138

    Abstract: Background: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial.: Objectives: To examine the association between perceived psychological stress and risk of HZ. ...

    Abstract Background: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial.
    Objectives: To examine the association between perceived psychological stress and risk of HZ.
    Methods: In a linked registry-based cohort study, we followed 77 310 persons aged 40 years or older who participated in the 2010 Danish National Health Survey from 1 May 2010 until HZ diagnosis, death, emigration or 1 July 2014, whichever occurred first. We computed hazard ratios (HRs) of HZ associated with Cohen's Perceived Stress Scale (PSS) score (range 0-40) using Cox regression with age as the timescale, adjusted for sex, immunosuppressive and selected chronic conditions, immunosuppressive drugs, and sociodemographic, lifestyle and anthropometric factors. The PSS measures chronic stress perceived by an individual in response to various demands of daily life. We modelled the PSS score using quintiles and a restricted cubic spline function.
    Results: The unadjusted rate of HZ varied from 5·53 to 7·20 per 1000 person-years from the lowest to the highest PSS score quintile. Compared with the lowest PSS score quintile, the adjusted HR for HZ was 1·00 [95% confidence interval (CI) 0·86-1·16], 1·08 (95% CI 0·92-1·26), 1·05 (95% CI 0·90-1·23) and 1·14 (95% CI 0·97-1·34) for the second to the fifth quintile, respectively. In cubic spline analyses, PSS scores < 20 were not associated with increased HR of HZ, but thereafter the HR increased linearly from 1·10 (95% CI 0·85-1·41) to 2·22 (95% CI 1·32-3·75).
    Conclusions: Our study indicated that high levels of psychological stress are associated with increased risk of HZ.
    Mesh-Begriff(e) Cohort Studies ; Herpes Zoster/epidemiology ; Herpesvirus 3, Human ; Humans ; Incidence ; Risk Factors ; Stress, Psychological/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2021-05-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.19832
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Alcohol use recording in adults with depression in English primary care: a cross-sectional study.

    Adesanya, Elizabeth / Cook, Sarah / Crellin, Elizabeth / Langan, Sinead / Mansfield, Kathryn / Smeeth, Liam / Herrett, Emily

    BMJ open

    2022  Band 12, Heft 1, Seite(n) e055975

    Abstract: Objectives: To investigate alcohol use recording in people with newly diagnosed depression in English primary care and individual characteristics associated with the recording of alcohol use.: Design: A population-based cross-sectional study.: ... ...

    Abstract Objectives: To investigate alcohol use recording in people with newly diagnosed depression in English primary care and individual characteristics associated with the recording of alcohol use.
    Design: A population-based cross-sectional study.
    Setting: Primary care data from English practices contributing to the UK Clinical Practice Research Datalink.
    Participants: We included adults (18+ years) diagnosed with depression between 1 January 2011 and 1 January 2017 without previous antidepressant use and at least 1 year of registration before diagnosis.
    Primary and secondary outcome measures: We described the proportion of individuals with alcohol use and level of alcohol use recorded at four time points (the date of depression diagnosis, 3 months before or after depression diagnosis, 12 months before or after depression diagnosis and any point pre or postdepression diagnosis). We used logistic regression to investigate individual characteristics associated with alcohol use recording in the 3 months before or after depression diagnosis.
    Results: We identified 36 424 adults with depression. 538 (2%) had alcohol use recorded in the 3 months before or after depression diagnosis using formal validated methods such as the Alcohol Use Disorders Identification Test and its abbreviated versions. At each time point, most individuals with alcohol use recorded were low risk drinkers. Alcohol use recording in the 3 months before or after depression diagnosis was associated with male sex (OR=1.38, 95% CI 1.29 to 1.48) and several other individual-level factors.
    Conclusions: Our study shows low levels of alcohol use recording in the 3 months before or after depression diagnosis. Levels of alcohol use recording varied depending on individual characteristics. Incentivised recording of alcohol use will increase completeness, which could improve clinical management and reduce missed opportunities for care in people with depression.
    Mesh-Begriff(e) Adult ; Alcohol Drinking/epidemiology ; Alcoholism/diagnosis ; Alcoholism/epidemiology ; Cross-Sectional Studies ; Depression/diagnosis ; Depression/epidemiology ; Humans ; Male ; Primary Health Care
    Sprache Englisch
    Erscheinungsdatum 2022-01-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-055975
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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