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  1. AU="Larkin, J"
  2. AU="Gilbert, A."
  3. AU="Jérémie Bruno"
  4. AU="Barg, Alexej"
  5. AU="Niranjan, M"
  6. AU="Solomon, Hilla"
  7. AU="de Aguiar Junior, Francisco Carlos Amanajás"
  8. AU=Carley David W
  9. AU="Solvig Ekblad"
  10. AU=Gibertoni Dino
  11. AU="Sein, Maung Kyaw"
  12. AU="Yun-Fei Xia"

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  1. Artikel: Surgery in Mercy Hospital.

    Larkin, J J

    The Chicago medical journal and examiner

    2023  Band 42, Heft 1, Seite(n) 52–54

    Sprache Englisch
    Erscheinungsdatum 2023-08-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Online: Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders

    Larkin, Jennie / Winslow, Raimond L / Qasba, Pankaj

    2014  

    Abstract: Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be ... ...

    Abstract Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both biology and medicine. Despite this dramatic progress, one of the greatest challenges that continues to confront modern biology is to understand how behavior at the level of genome, proteome and metabolome determines physiological function at the level of cell, tissue and organ in both health and disease. Because of the inherent complexity of biological systems, the development, analysis, and validation of integrative computational models based directly on experimental data is necessary to achieve this understanding.-

    This approach, known as systems biology, integrates computational and experimental approaches through iterative development of mathematical models and experimental validation and testing. The combination of these approaches allows for a mechanistic understanding of the function of complex biological systems in health and their dysfunction in disease. The National Heart, Lung, and Blood Institute (NHLBI) has recognized the importance of the systems biology approach for understanding normal physiology and perturbations associated with heart, lung, blood, and sleep diseases and disorders. In 2006, NHLBI announced the Exploratory Program in Systems Biology, followed in 2010 by the NHLBI Systems Biology Collaborations.-

    The goal of these programs is to support collaborative teams of investigators in using experimental and computational strategies to integrate the component parts of biological networks and pathways into computational models that are based firmly on and validated using experimental data. These validated models are then applied to gain insights into the mechanisms of altered system function in disease, to generate novel hypotheses regarding these mechanisms that can be tested experimentally, and to then use the results of experiments to refine the models. The purpose of this Research Topic is to present the range of innovative, new approaches being developed by investigators working in areas of systems biology that couple experimental and modeling studies to understand the cause and possible treatment of heart, lung, blood and sleep diseases and disorders.-
    Schlagwörter Biotechnology ; Engineering (General). Civil engineering (General) ; Physiology ; Science (General)
    Umfang 1 electronic resource (180 p.)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT020090033
    ISBN 9782889192496 ; 2889192490
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: Laser treatment for glaucoma.

    Larkin, John

    Lancet (London, England)

    2020  Band 396, Heft 10253, Seite(n) 754

    Mesh-Begriff(e) Glaucoma ; Humans ; Laser Therapy ; Ocular Hypertension ; Ophthalmic Solutions ; Trabeculectomy
    Chemische Substanzen Ophthalmic Solutions
    Sprache Englisch
    Erscheinungsdatum 2020-09-12
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31059-X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: To Browse, Click "Search".

    Larkin, John

    Scottish medical journal

    2019  Band 64, Heft 2, Seite(n) 41

    Mesh-Begriff(e) Biomedical Research ; Humans ; Online Systems ; Periodicals as Topic ; Publishing
    Sprache Englisch
    Erscheinungsdatum 2019-05-01
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 414085-0
    ISSN 2045-6441 ; 0036-9330
    ISSN (online) 2045-6441
    ISSN 0036-9330
    DOI 10.1177/0036933019848950
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Editorial.

    Larkin, John

    Scottish medical journal

    2019  Band 64, Heft 1, Seite(n) 1

    Mesh-Begriff(e) Humans ; Medicine ; Radiology ; Scotland
    Sprache Englisch
    Erscheinungsdatum 2019-02-19
    Erscheinungsland Scotland
    Dokumenttyp Editorial ; Introductory Journal Article
    ZDB-ID 414085-0
    ISSN 2045-6441 ; 0036-9330
    ISSN (online) 2045-6441
    ISSN 0036-9330
    DOI 10.1177/0036933019830890
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch ; Online: Coronavirus and Museum Resilience

    Larkin, Jamie

    Art Faculty Articles and Research

    Some Preliminary Observations

    2020  

    Abstract: The rapid spread of COVID-19 has led to virtually all UK museums being closed. The issue at hand is whether these temporary closures may become permanent, and which museums are likely to be the most resilient, both in the short and long term. These ... ...

    Abstract "The rapid spread of COVID-19 has led to virtually all UK museums being closed. The issue at hand is whether these temporary closures may become permanent, and which museums are likely to be the most resilient, both in the short and long term. These closures took place under very different circumstances to those we face today. Never before has the entire UK museum sector shutdown in this way, challenging the basic operating model of attracting visitors to physical sites. Here we consider what light our data might shed on the current situation."
    Schlagwörter Museum Studies ; covid19
    Erscheinungsdatum 2020-03-25T07:00:00Z
    Verlag Chapman University Digital Commons
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: A pyrrhic valedictory?

    Larkin, John

    Scottish medical journal

    2018  Band 63, Heft 4, Seite(n) 103

    Sprache Englisch
    Erscheinungsdatum 2018-11-01
    Erscheinungsland Scotland
    Dokumenttyp Editorial
    ZDB-ID 414085-0
    ISSN 2045-6441 ; 0036-9330
    ISSN (online) 2045-6441
    ISSN 0036-9330
    DOI 10.1177/0036933018811242
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Symptomatic melanoma CNS metastases in the TRICOTEL study.

    Schmitt, Andreas M / Larkin, James

    The Lancet. Oncology

    2022  Band 23, Heft 11, Seite(n) e481

    Mesh-Begriff(e) Humans ; Melanoma/pathology ; Central Nervous System Neoplasms/therapy ; Brain Neoplasms/therapy ; Brain Neoplasms/secondary ; Skin Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2022-10-31
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00566-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Personalized cancer care can't rely on molecular testing alone.

    Larkin, James / Beland, Chloe / Ramalingam, Sivatharshini / Lyon, Alexander R

    Nature

    2024  Band 627, Heft 8002, Seite(n) 38

    Mesh-Begriff(e) Humans ; Dissent and Disputes ; Molecular Diagnostic Techniques ; Neoplasms/classification ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine/methods ; Organ Specificity
    Sprache Englisch
    Erscheinungsdatum 2024-03-05
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-024-00631-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Lifileucel: the first cellular therapy approved for solid tumours.

    Julve, Max / Lythgoe, Mark P / Larkin, James / Furness, Andrew J S

    Trends in cancer

    2024  

    Abstract: The US Food and Drug Administration (FDA) approval of lifileucel, for advanced melanoma, represents the first cellular therapy to reach the clinic for solid cancers. Here, we summarise this landmark approval, consider the associated regulatory pathway, ... ...

    Abstract The US Food and Drug Administration (FDA) approval of lifileucel, for advanced melanoma, represents the first cellular therapy to reach the clinic for solid cancers. Here, we summarise this landmark approval, consider the associated regulatory pathway, and evaluate the challenges that remain to ensure effective implementation of this advanced 'living' therapy.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2024.04.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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