Artikel ; Online: Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer.
Cell chemical biology
2024 Band 31, Heft 5, Seite(n) 989–999.e7
Abstract: Human epidermal growth factor receptor 2 (HER2)-targeted agents have proven to be effective, however, the development of resistance to these agents has become an obstacle in treating HER2+ breast cancer. Evidence implicates HUNK as an anti-cancer target ... ...
Abstract | Human epidermal growth factor receptor 2 (HER2)-targeted agents have proven to be effective, however, the development of resistance to these agents has become an obstacle in treating HER2+ breast cancer. Evidence implicates HUNK as an anti-cancer target for primary and resistant HER2+ breast cancers. In this study, a selective inhibitor of HUNK is characterized alongside a phosphorylation event in a downstream substrate of HUNK as a marker for HUNK activity in HER2+ breast cancer. Rubicon has been established as a substrate of HUNK that is phosphorylated at serine (S) 92. Findings indicate that HUNK-mediated phosphorylation of Rubicon at S92 promotes both autophagy and tumorigenesis in HER2/neu+ breast cancer. HUNK inhibition prevents Rubicon S92 phosphorylation in HER2/neu+ breast cancer models and inhibits tumorigenesis. This study characterizes a downstream phosphorylation event as a measure of HUNK activity and identifies a selective HUNK inhibitor that has meaningful efficacy toward HER2+ breast cancer. |
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Mesh-Begriff(e) | Humans ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-2/antagonists & inhibitors ; Female ; Phosphorylation/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Mice ; Animals ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Mice, Nude ; Structure-Activity Relationship |
Chemische Substanzen | ERBB2 protein, human |
Sprache | Englisch |
Erscheinungsdatum | 2024-02-01 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ISSN | 2451-9448 |
ISSN (online) | 2451-9448 |
DOI | 10.1016/j.chembiol.2024.01.001 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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