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  1. Artikel ; Online: Reversion of glucocorticoid-induced senescence and collagen synthesis decrease by LY294002 is mediated through p38 in skin.

    Le, Quoc-Vu / Wen, Su-Ying / Chen, Chih-Jung / Huang, Chih-Yang / Kuo, Wei-Wen

    International journal of biological sciences

    2022  Band 18, Heft 16, Seite(n) 6102–6113

    Abstract: Glucocorticoids (GCs) are the most common treatment for inflammatory skin disorders; however, they show several adverse side effects, including atrophy and collagen decrease following chronic treatment. In particular, transcription factors and p38 ... ...

    Abstract Glucocorticoids (GCs) are the most common treatment for inflammatory skin disorders; however, they show several adverse side effects, including atrophy and collagen decrease following chronic treatment. In particular, transcription factors and p38 signaling for collagen synthesis have been shown to be suppressed by the active glucocorticoid receptor (GR). LY294002 (LY), a phosphoinositide 3-kinase (PI3K) inhibitor, has been reported to protect keratinocytes in epidermis against GC-induced hypoplasia; however, its protective effect in dermis remains unclear. Furthermore, clobetasol propionate (CP) is the most used commercial synthetic GC, yet studies on how CP causes side effects in dermal fibroblasts are limited. In this study, dermal atrophy was modeled using CP in human dermal fibroblasts (HDFs) and C57BL/6 mice. CP treatment significantly upregulated FK506 binding protein 5 (FKBP51), an atrophy marker (2.4 ± 0.25 and 3.3 ± 0.3 fold in
    Mesh-Begriff(e) Mice ; Humans ; Animals ; Glucocorticoids ; Phosphatidylinositol 3-Kinases ; Mice, Inbred C57BL ; Receptors, Glucocorticoid ; Phosphoinositide-3 Kinase Inhibitors ; Atrophy
    Chemische Substanzen 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (31M2U1DVID) ; Glucocorticoids ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Receptors, Glucocorticoid ; Phosphoinositide-3 Kinase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-10-18
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.73915
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti-pigmentation effects by regulating the CREB/MITF/tyrosinase pathway.

    Ho, Chih-Chu / Ng, Shang-Chuan / Chuang, Ho-Lin / Chen, Jia-Yi / Wen, Su-Ying / Kuo, Chia-Hua / Mahalakshmi, B / Le, Quoc-Vu / Huang, Chih-Yang / Kuo, Wei-Wen

    Environmental toxicology

    2020  Band 36, Heft 4, Seite(n) 654–664

    Abstract: Skin pigmentation is resulted from several processes, such as melanin synthesis transportation and abnormal melanin accumulation in keratinocytes. Various studies have suggested that seven traditional Chinese herbal extracts from Atractylodes ... ...

    Abstract Skin pigmentation is resulted from several processes, such as melanin synthesis transportation and abnormal melanin accumulation in keratinocytes. Various studies have suggested that seven traditional Chinese herbal extracts from Atractylodes macrocephala, Paeonia lactiflora, Bletilla striata, Poria cocos, Dictamnus dasycarpus, Ampelopsis japonica and Tribulus terrestris (which we collectively named ChiBai), show several protective effects toward skin-related diseases. Lactobacillus rhamnosus, a lactic acid bacterium, has been reported to treat skin inflammation and atopic dermatitis. In this study, the broth produced by the cofermentation of ChiBai with Lactobacillus rhamnosus was studied for its effects on skin pigmentation through in vitro and in vitro experiments. In the in vitro experiments, we found that the fermented broth of ChiBai (FB-ChiBai) suppressed alpha-melanocyte stimulating hormone (α-MSH)-induced melanogenesis in B16F0 murine melanoma cells without any cytotoxicity at a concentration of 0.5%. FB-ChiBai significantly attenuated melanin production, tyrosinase activities and melanogenesis-related signaling pathways. Treatment with FB-ChiBai also reduced the nuclear translocation and promoter binding activities of MITF. In the in vivo experiments, FB-ChiBai was topically applied to the dorsal skin of C57BL/6J nude mice and concurrently irradiated with UVB, three times a week for 8 weeks. The results indicated that FB-ChiBai alleviated UVB-induced hyperpigmentation by reducing epidermal hyperplasia and inhibiting the CREB/MITF/tyrosinase pathway. In conclusion, our data indicated that the anti-melanogenic effects of FB-ChiBai are mediated by the inhibition of CREB/MITF/tyrosinase signaling pathway. The findings suggest that FB-ChiBai can protect against UV-B irradiation and that it might be used as an agent in cosmetic products to protect against UVB-induced hyperpigmentation.
    Mesh-Begriff(e) Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Fermentation ; Humans ; Lactobacillus rhamnosus/metabolism ; Melanins/biosynthesis ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Microphthalmia-Associated Transcription Factor/metabolism ; Monophenol Monooxygenase/metabolism ; Signal Transduction ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Skin/radiation effects ; Skin Pigmentation/drug effects ; Skin Pigmentation/radiation effects ; Ultraviolet Rays ; alpha-MSH/antagonists & inhibitors
    Chemische Substanzen Drugs, Chinese Herbal ; Melanins ; Microphthalmia-Associated Transcription Factor ; alpha-MSH (581-05-5) ; Monophenol Monooxygenase (EC 1.14.18.1)
    Sprache Englisch
    Erscheinungsdatum 2020-12-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23069
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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