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Artikel ; Online: Identifying Giant Cell Arteritis patients with higher risk of relapse and vascular events: a cluster analysis.

Guédon, Alexis F / Froger, Chloé / Agard, Christian / Bénichou, Antoine / Le Jeune, Sylvain / Mekinian, Arsène / Morard, Marie / Skaff, Yara / de Boysson, Hubert / Espitia, Olivier

QJM : monthly journal of the Association of Physicians

2024

Abstract: Objective: Giant cell arteritis (GCA) is one of the most common large vessel (LVV) vasculitis and is associated with a high risk of relapse and cardiovascular complications. Improving risk stratification remains a significant issue in this patient ... ...

Abstract	Objective: Giant cell arteritis (GCA) is one of the most common large vessel (LVV) vasculitis and is associated with a high risk of relapse and cardiovascular complications. Improving risk stratification remains a significant issue in this patient population. We aimed to perform a cluster analysis among GCA to identify clusters and evaluate their prognostic value. Methods: In a multicenter cohort study, we performed hierarchical cluster analysis on the factor analysis of mixed data coordinates results with 283 GCA patients' characteristics to generate clusters and assess incidence of relapse, cardiovascular events and death. Results: Three clusters were identified: "Vascular relapsing profile" (23.0%), "Typical GCA profile" (47.7%), and "Ophthalmologic elderly profile" (29.3%). The "Vascular relapsing profile" cluster included younger patients with more frequent relapses and cardiovascular events, particularly thoracic aortic aneurysms. The "Typical GCA profile" was the largest, with classic cranial manifestations and frequently associated polymyalgia rheumatica. The "Ophthalmologic elderly profile" had the oldest patients with more visual loss and the highest mortality rate. Conclusions: Our findings underline the varied prognostic landscape within GCA, emphasizing the poor cardiovascular prognosis of younger patients with LV involvement and the higher mortality among elderly patients. This reinforces the need for further research regarding the screening of aortic abnormalities and whether those patients might benefit from intensive treatment with biotherapy and cardiovascular risk factors management.
Sprache	Englisch
Erscheinungsdatum	2024-05-28
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcae105
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Management of the antiplatelet therapy during the diagnosis of venous thromboembolism disease: A national survey of French general practitioners' compared to the French vascular physicians' management.

Fayol, Antoine / Plaisance, Ludovic / Poenou, Géraldine / Helfer, Hélène / Le Jeune, Sylvain / Mahé, Isabelle

Journal de medecine vasculaire

2020 Band 45, Heft 3, Seite(n) 107–113

Abstract: Introduction: Approximately 15% of patients treated by anticoagulant for a venous thromboembolic event are also treated with antiplatelet therapy; and this association increases the risk of bleeding. The aim of this survey was to evaluate general ... ...

Abstract	Introduction: Approximately 15% of patients treated by anticoagulant for a venous thromboembolic event are also treated with antiplatelet therapy; and this association increases the risk of bleeding. The aim of this survey was to evaluate general practitioner's management of antiplatelet therapy at the initiation of anticoagulation, and at six months compared to French vascular physicians' management. Methods: A questionnaire including 4 clinical situations was established and the physicians were asked to detail antiplatelet and anticoagulant therapy management. From September 2017 to December 2017, an e-mail invitation and a reminder were sent to members of the departmental councils who participated; 218 questionnaires were obtained. Results: Overall, 91.3% of physicians considered that there was an increased risk of bleeding when antiplatelet therapy is associated with anticoagulation. After initiating anticoagulation, 67% of respondents continued antiplatelet therapy, while 30% stopped. Three strategies were used: 49.0% of physicians maintained concomitant antiplatelet therapy with full-dose anticoagulant, both at anticoagulant initiation and at 6 months; 23% of physicians stopped antiplatelet therapy and prescribed full-dose anticoagulant at initiation and at 6 months; 12.4% of physicians prescribed antiplatelet therapy associated with reduced-dose anticoagulation at 6 months regardless of the strategy at anticoagulant initiation. Conclusion: One third of general practitioners stopped antiplatelet therapy at the initiation of an anticoagulation for a venous thromboembolic event. Prospective controlled trials are needed to clarify the best way to treat these patients in this situation.
Mesh-Begriff(e)	Adult ; Aged ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Drug Utilization/trends ; Female ; France/epidemiology ; General Practitioners/trends ; Health Care Surveys ; Hemorrhage/chemically induced ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/adverse effects ; Practice Patterns, Physicians'/trends ; Recurrence ; Risk Assessment ; Risk Factors ; Specialization/trends ; Time Factors ; Treatment Outcome ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology
Chemische Substanzen	Anticoagulants ; Platelet Aggregation Inhibitors
Sprache	Englisch
Erscheinungsdatum	2020-04-22
Erscheinungsland	France
Dokumenttyp	Comparative Study ; Journal Article
ISSN	2542-4513
ISSN	2542-4513
DOI	10.1016/j.jdmv.2020.04.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Relationship between accessory renal arteries and resistant hypertension: A cohort study.

Maisons, Valentin / Le Jeune, Sylvain / Barber-Chamoux, Nicolas / Boudghene-Stambouli, Fanny / Brucker, Marie / Delsart, Pascal / Lopez-Sublet, Marilucy / Perez, Laurence / Radhouani, Ibtissem / Sosner, Philippe / Sautenet, Bénédicte

Journal de medecine vasculaire

2023 Band 48, Heft 1, Seite(n) 18–23

Abstract: Background: Resistant hypertension (RHT) is a major health care concern affecting 20 to 30% of hypertensive patients and increasing cardiovascular risk. Recent renal denervation trials have suggested a high prevalence of accessory renal arteries (ARA) ... ...

Abstract	Background: Resistant hypertension (RHT) is a major health care concern affecting 20 to 30% of hypertensive patients and increasing cardiovascular risk. Recent renal denervation trials have suggested a high prevalence of accessory renal arteries (ARA) in RHT. Our objective was to compare the prevalence of ARA in RHT vs. non-resistant hypertension (NRHT). Methods: Eighty-six patients with essential hypertension who benefited from an abdominal CT-scan or MRI during their initial workup were retrospectively recruited in 6 French ESH (European Society of Hypertension) centers. At the end of a follow-up period of at least 6 months, patients were classified between RHT or NRHT. RHT was defined as uncontrolled blood pressure despite the optimal doses of three antihypertensive agents of which one is a diuretic or similar, or controlled by ≥ 4 medications. Blinded independent central review of all radiologic renal artery charts was performed. Results: Baseline characteristics were: age 50±15 years, 62% males, BP 145±22/87±13mmHg. Fifty-three (62%) patients had RHT and 25 (29%) had at least one ARA. Prevalence of ARA was comparable between RHT (25%) and NRHT patients (33%, P=0.62), but there were more ARA per patient in NRHT (2±0.9) vs. RHT (1.3±0.5, P=0.05), and renin levels were higher in ARA group (51.6±41.7 mUI/L vs. 20.4±25.4 mUI/L, P=0.001). ARA were similar in diameter or length between the 2 groups. Conclusions: In this retrospective series of 86 essential hypertension patients, we found no difference in the prevalence of ARA in RHT and NRHT. More comprehensive studies are needed to answer this question.
Mesh-Begriff(e)	Male ; Humans ; Adult ; Middle Aged ; Aged ; Female ; Renal Artery/diagnostic imaging ; Retrospective Studies ; Cohort Studies ; Hypertension/drug therapy ; Hypertension/epidemiology ; Essential Hypertension
Sprache	Englisch
Erscheinungsdatum	2023-04-05
Erscheinungsland	France
Dokumenttyp	Journal Article
ISSN	2542-4513
ISSN	2542-4513
DOI	10.1016/j.jdmv.2023.03.001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub-Saharan Africa (the BIOCADRE study).

Ranque, Brigitte / Diaw, Mor / Dembele, Abdoul Karim / Lapoumeroulie, Claudine / Offredo, Lucile / Tessougue, Oumar / Gueye, Serigne Mourtalla / Diallo, Dapa / Diop, Saliou / Colin-Aronovicz, Yves / Jouven, Xavier / Blanc-Brude, Olivier / Tharaux, Pierre-Louis / Le Jeune, Sylvain / Connes, Philippe / Romana, Marc / Le Van Kim, Caroline

British journal of haematology

2023 Band 203, Heft 2, Seite(n) 319–326

Abstract: Sickle cell anaemia (SCA) is a monogenic disease with a highly variable clinical course. We aimed to investigate associations between microvascular function, haemolysis markers, blood viscosity and various types of SCA-related organ damage in a ... ...

Abstract	Sickle cell anaemia (SCA) is a monogenic disease with a highly variable clinical course. We aimed to investigate associations between microvascular function, haemolysis markers, blood viscosity and various types of SCA-related organ damage in a multicentric sub-Saharan African cohort of patients with SCA. In a cross-sectional study, we selected seven groups of adult patients with SS phenotype in Dakar and Bamako based on the following complications: leg ulcer, priapism, osteonecrosis, retinopathy, high tricuspid regurgitant jet velocity (TRV), macro-albuminuria or none. Clinical assessment, echocardiography, peripheral arterial tonometry, laboratory tests and blood viscosity measurement were performed. We explored statistical associations between the biological parameters and the six studied complications. Among 235 patients, 58 had high TRV, 46 osteonecrosis, 43 priapism, 33 leg ulcers, 31 retinopathy and 22 macroalbuminuria, whereas 36 had none of these complications. Multiple correspondence analysis revealed no cluster of complications. Lactate dehydrogenase levels were associated with high TRV, and blood viscosity was associated with retinopathy and the absence of macroalbuminuria. Despite extensive phenotyping of patients, no specific pattern of SCA-related complications was identified. New biomarkers are needed to predict SCA clinical expression to adapt patient management, especially in Africa, where healthcare resources are scarce.
Mesh-Begriff(e)	Male ; Adult ; Humans ; Hemolysis ; Blood Viscosity ; Priapism ; Cross-Sectional Studies ; Microcirculation ; Senegal ; Anemia, Sickle Cell ; Leg Ulcer/etiology ; Retinal Diseases/etiology ; Osteonecrosis
Sprache	Englisch
Erscheinungsdatum	2023-08-15
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.19006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: High prevalence of early asymptomatic venous thromboembolism in anticoagulated COVID-19 patients hospitalized in general wards.

Le Jeune, Sylvain / Suhl, Jaehyo / Benainous, Ruben / Minvielle, François / Purser, Christine / Foudi, Farid / Warzocha, Ursula / Dhote, Robin

Journal of thrombosis and thrombolysis

2020 Band 51, Heft 3, Seite(n) 637–641

Abstract: Coronavirus disease 2019 (COVID-19) is associated with coagulation activation and high incidence of venous thromboembolism (VTE) in severe patients despite routine thromboprophylaxis. Conflicting results exist regarding the epidemiology of VTE for ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is associated with coagulation activation and high incidence of venous thromboembolism (VTE) in severe patients despite routine thromboprophylaxis. Conflicting results exist regarding the epidemiology of VTE for unselected anticoagulated COVID-19 patients hospitalized in general wards. The aim of this study was to evaluate the prevalence of asymptomatic deep venous thrombosis (DVT) in unselected patients with COVID-19 recently hospitalized in general wards. We performed a systematic complete doppler ultrasound (CDU) at a median 4 days after admission in 42 consecutive COVID-19 patients hospitalized in general wards of our university hospital, irrespective of D-Dimer level, and retrospectively collected clinical, biological and outcome data from electronic charts. Thromboprophylaxis was systematically applied following a French national proposal. In our population, the prevalence of asymptomatic DVT was 19% (8/42 patients), with distal thrombosis in 7/8 cases and bilateral DVT in 4/8 cases. Symptomatic pulmonary embolism was detected in 4 (9.5%) patients, associated to DVT in one case. Compared to patients without DVT, patients with DVT were older and experienced poorer outcomes. In conclusion, prevalence of asymptomatic DVT is high in the first days of hospitalization of unselected COVID-19 patients in general wards and may be related to poor prognosis. Individualized assessment of thromboprophylaxis and early systematic screening for DVT is warranted in this context.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Asymptomatic Diseases/epidemiology ; COVID-19/complications ; COVID-19/diagnostic imaging ; COVID-19/epidemiology ; Female ; France/epidemiology ; Humans ; Inpatients/statistics & numerical data ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Ultrasonography, Doppler ; Venous Thromboembolism/diagnostic imaging ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/virology
Chemische Substanzen	Anticoagulants
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-08-18
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-020-02246-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Low grade intravascular hemolysis associates with peripheral nerve injury in type 2 diabetes.

Le Jeune, Sylvain / Sadoudi, Sihem / Charue, Dominique / Abid, Salwa / Guigner, Jean-Michel / Helley, Dominique / Bihan, Hélène / Baudry, Camille / Lelong, Hélène / Mirault, Tristan / Vicaut, Eric / Dhote, Robin / Mourad, Jean-Jacques / Boulanger, Chantal M / Blanc-Brude, Olivier P

PloS one

2022 Band 17, Heft 10, Seite(n) e0275337

Abstract: Type 2 diabetes (T2D) induces hyperglycemia, alters hemoglobin (Hb), red blood cell (RBC) deformability and impairs hemorheology. The question remains whether RBC breakdown and intravascular hemolysis (IVH) occur in T2D patients. We characterized RBC- ... ...

Abstract	Type 2 diabetes (T2D) induces hyperglycemia, alters hemoglobin (Hb), red blood cell (RBC) deformability and impairs hemorheology. The question remains whether RBC breakdown and intravascular hemolysis (IVH) occur in T2D patients. We characterized RBC-degradation products and vesiculation in a case-control study of 109 T2D patients and 65 control subjects. We quantified heme-related absorbance by spectrophotometry and circulating extracellular vesicles (EV) by flow cytometry and electron microscopy. Heme-related absorbance was increased in T2D vs. control plasma (+57%) and further elevated in obese T2D plasma (+27%). However, large CD235a+ EV were not increased in T2D plasma. EV from T2D plasma, or shed by isolated T2D RBC, were notably smaller in diameter (-27%) and carried heme-related absorbance. In T2D plasma, higher heme-related absorbance (+30%) was associated to peripheral sensory neuropathy, and no other vascular complication. In vitro, T2D RBC-derived EV triggered endothelial stress and thrombin activation in a phosphatidylserine- and heme-dependent fashion. We concluded that T2D was associated with low-grade IVH. Plasma absorbance may constitute a novel biomarker of peripheral neuropathy in T2D, while flow cytometry focusing on large EV may be maladapted to characterize RBC EV in T2D. Moreover, therapeutics limiting IVH or neutralizing RBC breakdown products might bolster vasculoprotection in T2D.
Mesh-Begriff(e)	Biomarkers/metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Erythrocytes/metabolism ; Heme/metabolism ; Hemoglobins/metabolism ; Hemolysis ; Humans ; Peripheral Nerve Injuries/metabolism ; Phosphatidylserines/metabolism ; Thrombin/metabolism
Chemische Substanzen	Biomarkers ; Hemoglobins ; Phosphatidylserines ; Heme (42VZT0U6YR) ; Thrombin (EC 3.4.21.5)
Sprache	Englisch
Erscheinungsdatum	2022-10-17
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0275337
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: High prevalence of early asymptomatic venous thromboembolism in anticoagulated COVID-19 patients hospitalized in general wards

Le Jeune, Sylvain / Suhl, Jaehyo / Benainous, Ruben / Minvielle, François / Purser, Christine / Foudi, Farid / Warzocha, Ursula / Dhote, Robin

J. thromb. thrombolysis

Abstract	Coronavirus disease 2019 (COVID-19) is associated with coagulation activation and high incidence of venous thromboembolism (VTE) in severe patients despite routine thromboprophylaxis. Conflicting results exist regarding the epidemiology of VTE for unselected anticoagulated COVID-19 patients hospitalized in general wards. The aim of this study was to evaluate the prevalence of asymptomatic deep venous thrombosis (DVT) in unselected patients with COVID-19 recently hospitalized in general wards. We performed a systematic complete doppler ultrasound (CDU) at a median 4 days after admission in 42 consecutive COVID-19 patients hospitalized in general wards of our university hospital, irrespective of D-Dimer level, and retrospectively collected clinical, biological and outcome data from electronic charts. Thromboprophylaxis was systematically applied following a French national proposal. In our population, the prevalence of asymptomatic DVT was 19% (8/42 patients), with distal thrombosis in 7/8 cases and bilateral DVT in 4/8 cases. Symptomatic pulmonary embolism was detected in 4 (9.5%) patients, associated to DVT in one case. Compared to patients without DVT, patients with DVT were older and experienced poorer outcomes. In conclusion, prevalence of asymptomatic DVT is high in the first days of hospitalization of unselected COVID-19 patients in general wards and may be related to poor prognosis. Individualized assessment of thromboprophylaxis and early systematic screening for DVT is warranted in this context.
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #718463
Datenquelle	COVID19

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Artikel ; Online: High prevalence of early asymptomatic venous thromboembolism in anticoagulated COVID-19 patients hospitalized in general wards

Le Jeune, Sylvain / Suhl, Jaehyo / Benainous, Ruben / Minvielle, François / Purser, Christine / Foudi, Farid / Warzocha, Ursula / Dhote, Robin

Journal of Thrombosis and Thrombolysis ; ISSN 0929-5305 1573-742X

2020

Schlagwörter	Hematology ; Cardiology and Cardiovascular Medicine ; covid19
Sprache	Englisch
Verlag	Springer Science and Business Media LLC
Erscheinungsland	us
Dokumenttyp	Artikel ; Online
DOI	10.1007/s11239-020-02246-w
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Heart protection: a key target in the management of patients with diabetes.

Mourad, Jean-Jacques / Le Jeune, Sylvain

Journal of hypertension. Supplement : official journal of the International Society of Hypertension

2009 Band 27, Heft 1, Seite(n) S9–13

Abstract: Cardiovascular disease is responsible for 70% of all mortality among patients with type 2 diabetes and is also a major contributor to diabetes-related healthcare costs. The ADVANCE trial clearly demonstrated that a simple and easily applicable ... ...

Abstract	Cardiovascular disease is responsible for 70% of all mortality among patients with type 2 diabetes and is also a major contributor to diabetes-related healthcare costs. The ADVANCE trial clearly demonstrated that a simple and easily applicable pharmacological strategy based on perindopril/indapamide fixed combination could substantially reduce total and cardiovascular mortality (-14% and -18%, respectively). The observed benefits were largely caused by a substantial decrease in systolic blood pressure (SBP), confirming the need to have ambitious therapeutic goals in such high-risk patients. This point is of importance because most of the patients included in the trial were being treated for hypertension, and baseline brachial SBP and diastolic blood pressure at inclusion were very close to normal. Previous mechanistic studies have highlighted the positive effect of perindopril/indapamide fixed combination on large artery function as well as on microvascular structure. For example, in the REASON trial, in patients treated with perindopril/indapamide, the decrease in central aortic SBP, which closely correlated with the decrease in left ventricular hypertrophy, reflected a significant improvement in large artery function and a changing pattern in both peripheral reflection coefficients and structural arteriolar network. These data are supported by those from other studies, which show increases in coronary blood flow reserve with perindopril/indapamide treatment. In conclusion, normalization of SBP, pulse pressure, arterial function and myocardial perfusion, a haemodynamic profile known to improve survival in the hypertensive populations at high cardiovascular risk, seems to be more easily achieved when a strategy based on the perindopril/indapamide combination is applied.
Mesh-Begriff(e)	Blood Pressure ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Diabetes Complications ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Indapamide/administration & dosage ; Indapamide/therapeutic use ; Perindopril/administration & dosage ; Perindopril/therapeutic use
Chemische Substanzen	Indapamide (F089I0511L) ; Perindopril (Y5GMK36KGY)
Sprache	Englisch
Erscheinungsdatum	2009-05
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	1747-3667
ISSN (online)	1747-3667
DOI	10.1097/01.hjh.0000354418.77815.7a
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Thoracic aorta involvement in giant cell arteritis: a case-control analysis of morphological data at diagnosis.

Rodrigues, François / Abad, Sébastien / Elourimi, Ghassan / Le Jeune, Sylvain / Mourad, Jean-Jacques / Warzocha, Ursula / Larroche, Claire / Boissier, Marie Christophe / Bourgarit-Durand, Anne / Brillet, Pierre Yves / Mekinian, Arsene / Soussan, Michael / Dhote, Robin

Clinical and experimental rheumatology

2019 Band 38, Heft 1, Seite(n) 140–143

Abstract: Objectives: Giant cell arteritis (GCA) is a cause of potentially fatal aortic aneurysms. Descriptive data on thoracic aorta measurements at the beginning of the disease are lacking. We aimed to compare aortic diameters between a recently diagnosed GCA ... ...

Abstract	Objectives: Giant cell arteritis (GCA) is a cause of potentially fatal aortic aneurysms. Descriptive data on thoracic aorta measurements at the beginning of the disease are lacking. We aimed to compare aortic diameters between a recently diagnosed GCA population and an age- and sex-matched control group. Methods: Patients with GCA and with an available thoracic CT concomitant with diagnosis were included. Controls were patients matched for age and sex and hospitalised in the same care centre for pneumonia. The main criteria were the anteroposterior and lateral diameters of the ascending thoracic aorta, which were measured by a blinded evaluator. Results: 90 cases and 90 controls were included. Each group comprised 30 males and 60 females for a mean age of 75.1±9 and 75.7±10.1 years old. At the time of GCA diagnosis no difference was found between the two groups (anteroposterior diameter 37.1±5 mm for cases vs. 36.7±5 mm for controls, p=0.6; lateral diameter 36.6±5 mm for cases vs. 35.9±4 mm for controls, p=0.3). Thoracic aorta diameter was not significantly higher in patients with aortitis at diagnosis (n=44) than in cases without aortitis (n=46). Conclusions: Morphologic comparison of thoracic aorta at diagnosis of GCA with an age- and sex-matched control population showed no significant difference. Morphologic evaluation of aorta cannot predict accurately the occurrence of aortic aneurysm. Systematic follow-up according to current recommendations is thus justified.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Aorta, Thoracic/pathology ; Aortic Aneurysm ; Aortitis ; Female ; Giant Cell Arteritis/pathology ; Humans ; Male
Sprache	Englisch
Erscheinungsdatum	2019-08-03
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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