Artikel ; Online: Resveratrol Reverses Endothelial Colony-Forming Cell Dysfunction in Adulthood in a Rat Model of Intrauterine Growth Restriction.
International journal of molecular sciences
2023 Band 24, Heft 11
Abstract: Individuals born after intrauterine growth restriction (IUGR) are at risk of developing cardiovascular diseases (CVDs). Endothelial dysfunction plays a role in the pathogenesis of CVDs; and endothelial colony-forming cells (ECFCs) have been identified as ...
| Abstract | Individuals born after intrauterine growth restriction (IUGR) are at risk of developing cardiovascular diseases (CVDs). Endothelial dysfunction plays a role in the pathogenesis of CVDs; and endothelial colony-forming cells (ECFCs) have been identified as key factors in endothelial repair. In a rat model of IUGR induced by a maternal low-protein diet, we observed an altered functionality of ECFCs in 6-month-old males, which was associated with arterial hypertension related to oxidative stress and stress-induced premature senescence (SIPS). Resveratrol (R), a polyphenol compound, was found to improve cardiovascular function. In this study, we investigated whether resveratrol could reverse ECFC dysfunctions in the IUGR group. ECFCs were isolated from IUGR and control (CTRL) males and were treated with R (1 μM) or dimethylsulfoxide (DMSO) for 48 h. In the IUGR-ECFCs, R increased proliferation (5'-bromo-2'-deoxyuridine (BrdU) incorporation, |
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| Mesh-Begriff(e) | Humans ; Male ; Female ; Rats ; Animals ; Fetal Growth Retardation/metabolism ; Resveratrol/pharmacology ; Resveratrol/metabolism ; Fluorescent Dyes/metabolism ; Endothelial Cells/metabolism ; Cardiovascular Diseases/metabolism ; Cell Proliferation ; Cells, Cultured |
| Chemische Substanzen | Resveratrol (Q369O8926L) ; Fluorescent Dyes |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-06-05 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms24119747 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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