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Artikel ; Online: Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance.

Jalalirad, Mohammad / Haddad, Tufia C / Salisbury, Jeffrey L / Radisky, Derek / Zhang, Minzhi / Schroeder, Mark / Tuma, Ann / Leof, Eduard / Carter, Jodi M / Degnim, Amy C / Boughey, Judy C / Sarkaria, Jann / Yu, Jia / Wang, Liewei / Liu, Minetta C / Zammataro, Luca / Malatino, Lorenzo / Galanis, Evanthia / Ingle, James N /
Goetz, Matthew P / D'Assoro, Antonino B

Oncogene

2021  Band 40, Heft 14, Seite(n) 2509–2523

Abstract: Triple-negative breast cancer (TNBCs) account for 15-20% of all breast cancers and represent the most aggressive subtype of this malignancy. Early tumor relapse and progression are linked to the enrichment of a sub-fraction of cancer cells, termed breast ...

Abstract Triple-negative breast cancer (TNBCs) account for 15-20% of all breast cancers and represent the most aggressive subtype of this malignancy. Early tumor relapse and progression are linked to the enrichment of a sub-fraction of cancer cells, termed breast tumor-initiating cells (BTICs), that undergo epithelial to mesenchymal transition (EMT) and typically exhibit a basal-like CD44
Mesh-Begriff(e) Aurora Kinase A/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/mortality ; Cell Plasticity/genetics ; Female ; Humans ; Signal Transduction ; Survival Analysis
Chemische Substanzen Aurora Kinase A (EC 2.7.11.1)
Sprache Englisch
Erscheinungsdatum 2021-03-05
Erscheinungsland England
Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID 639046-8
ISSN 1476-5594 ; 0950-9232
ISSN (online) 1476-5594
ISSN 0950-9232
DOI 10.1038/s41388-021-01711-x
Signatur
Zs.A 2218: Hefte anzeigen Standort:
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Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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