Artikel: Negative correlation between metabolic score for insulin resistance index and testosterone in male adults.
Diabetology & metabolic syndrome
2024 Band 16, Heft 1, Seite(n) 113
Abstract: Background: Insulin resistance (IR) is strongly correlated with the decreased deficiency of testosterone levels in males. The metabolic score for insulin resistance (METS-IR) index is regarded as an innovative measure for the assessment on IR. The ... ...
Abstract | Background: Insulin resistance (IR) is strongly correlated with the decreased deficiency of testosterone levels in males. The metabolic score for insulin resistance (METS-IR) index is regarded as an innovative measure for the assessment on IR. The research aims to explore the correlation between the METS-IR index and the testosterone levels in males. Methods: In this study, a cross-sectional design was made through the data obtained from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. Besides, the METS-IR index was derived from serum triglyceride levels, fasting plasma glucose, HDL-C and BMI. Results: A total of 2082 participants were included in the final analysis. After controlling for confounding variables, it was found that METS-IR was independently and negatively correlated with testosterone levels (β = -3.88, 95% CI = -4.49, -3.27, P < 0.001). As shown by the generalized smooth curve fitting, METS-IR had a linear correlation with testosterone levels without threshold or saturation effects, which was consistently observed across all subgroups through stratified analysis (all P > 0.05). As revealed by the analysis on the ROC curve, the area under the curve (AUC) for the METS-IR index (0.732, 95% CI = 0.705, 0.760) was significantly larger than that of homeostatic model assessment of insulin resistance (HOMA-IR), TG/HDL ratio, triglyceride-glucose index (TyG) and body mass index (BMI). Conclusion: The findings suggest a negative relationship between the METS-IR index and the testosterone levels in male adults. Furthermore, the METS-IR index demonstrates superior predictive ability for testosterone deficiency in comparison to HOMA-IR, TG/HDL ratio, TyG and BMI. |
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Sprache | Englisch |
Erscheinungsdatum | 2024-05-23 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 2518786-7 |
ISSN | 1758-5996 |
ISSN | 1758-5996 |
DOI | 10.1186/s13098-024-01353-5 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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