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  1. Artikel ; Online: Modified Minimally Invasive Bunnell Suture Surgery with Channel-assisted Minimally Invasive Reconstruction Device for Treating Achilles Tendon Rupture.

    Li, Chao / Li, Fu-Chun

    Zeitschrift fur Orthopadie und Unfallchirurgie

    2024  

    Abstract: The aim of this study was to improve the process of microincision and endoscopic surgery for the treatment of Achilles tendon (AT) rupture using the modified minimally invasive Bunnell suture (MIBS) technique.From December 2019 to December 2021, 20 ... ...

    Titelübersetzung Modifizierte minimal-invasive Bunnell-Nahtoperation mit kanalunterstütztem minimal-invasivem Rekonstruktionsinstrument zur Behandlung der Achillessehnenruptur.
    Abstract The aim of this study was to improve the process of microincision and endoscopic surgery for the treatment of Achilles tendon (AT) rupture using the modified minimally invasive Bunnell suture (MIBS) technique.From December 2019 to December 2021, 20 patients with AT rupture who visited the First Affiliated Hospital of Harbin Medical University (Harbin, China) underwent MIBS surgery.A total of 20 patients were included, of whom 18 (90.0%) were male and 2 (10.0%) were female. The mean age of the patients was 37.75 ± 9.94 years. In terms of the site of the AT, two (10.0%) had surgery on their left AT. The mean duration of surgery was 23.00 ± 2.47 minutes, and the mean bleeding volume was 5.00 ± 1.12 mL. All 20 patients (100%) showed complete incisional healing (stage I healing) and normal functional recovery (3-6 months postoperatively). There were no cases of abnormal functional recovery or postoperative recurrence within the 3-6 month follow-up period. The Achilles tendon Total Rupture Score (ATRS) significantly improved post-surgery (83.6 ± 5.59) compared to pretreatment (0.3 ± 0.92, p < 0.0001), indicating successful patient recovery.After the modified MIBS surgical process, the operation steps were simplified, the surgical difficulty was reduced, and the surgical trauma was alleviated, resulting in good postoperative recovery and patient satisfaction with the outcome. Therefore, the MIBS surgery has high promotability.
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/a-2294-1043
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The Arf family GTPases: Regulation of vesicle biogenesis and beyond.

    Li, Fu-Long / Guan, Kun-Liang

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2023  Band 45, Heft 6, Seite(n) e2200214

    Abstract: The Arf family proteins are best known for their roles in the vesicle biogenesis. However, they also play fundamental roles in a wide range of cellular regulation besides vesicular trafficking, such as modulation of lipid metabolic enzymes, cytoskeleton ... ...

    Abstract The Arf family proteins are best known for their roles in the vesicle biogenesis. However, they also play fundamental roles in a wide range of cellular regulation besides vesicular trafficking, such as modulation of lipid metabolic enzymes, cytoskeleton remodeling, ciliogenesis, lysosomal, and mitochondrial morphology and functions. Growing studies continue to expand the downstream effector landscape of Arf proteins, especially for the less-studied members, revealing new biological functions, such as amino acid sensing. Experiments with cutting-edge technologies and in vivo functional studies in the last decade help to provide a more comprehensive view of Arf family functions. In this review, we summarize the cellular functions that are regulated by at least two different Arf members with an emphasis on those beyond vesicle biogenesis.
    Mesh-Begriff(e) ADP-Ribosylation Factors/metabolism
    Chemische Substanzen ADP-Ribosylation Factors (EC 3.6.5.2)
    Sprache Englisch
    Erscheinungsdatum 2023-03-30
    Erscheinungsland United States
    Dokumenttyp Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202200214
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Modified Minimally Invasive Bunnell Suture Surgery with Channel-assisted Minimally Invasive Reconstruction Device for Treating Achilles Tendon Rupture

    Li, Chao / Li, Fu-chun

    Zeitschrift für Orthopädie und Unfallchirurgie

    2024  

    Abstract: The aim of this study was to improve the process of microincision and endoscopic ... surgery for the treatment of Achilles tendon (AT) rupture using the modified ... minimally invasive Bunnell suture (MIBS) technique. From December 2019 to December 2021, ... ...

    Abstract The aim of this study was to improve the process of microincision and endoscopic

    surgery for the treatment of Achilles tendon (AT) rupture using the modified

    minimally invasive Bunnell suture (MIBS) technique. From December 2019 to December 2021, 20 patients with AT rupture who visited the

    First Affiliated Hospital of Harbin Medical University (Harbin, China) underwent

    MIBS surgery. A total of 20 patients were included, of whom 18 (90.0%) were male and 2 (10.0%)

    were female. The mean age of the patients was 37.75 ± 9.94 years. In terms of the

    site of the AT, two (10.0%) had surgery on their left AT. The mean duration of

    surgery was 23.00 ± 2.47 minutes, and the mean bleeding volume was 5.00 ± 1.12 mL.

    All 20 patients (100%) showed complete incisional healing (stage I healing) and

    normal functional recovery (3–6 months postoperatively). There were no cases of

    abnormal functional recovery or postoperative recurrence within the 3–6 month

    follow-up period. The Achilles tendon Total Rupture Score (ATRS) significantly

    improved post-surgery (83.6 ± 5.59) compared to pretreatment (0.3 ± 0.92,

    p < 0.0001), indicating successful patient recovery. After the modified MIBS surgical process, the operation steps were simplified, the

    surgical difficulty was reduced, and the surgical trauma was alleviated, resulting

    in good postoperative recovery and patient satisfaction with the outcome. Therefore,

    the MIBS surgery has high promotability.
    Schlagwörter Achilles tendon rupture ; tunnel-assisted suture system ; minimally invasive surgery ; Riss der Achillessehne ; tunnelgestütztes Naht-System ; minimalinvasive Chirurgie
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/a-2294-1043
    Datenquelle Thieme Verlag

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  4. Artikel ; Online: Causal influences of osteoarthritis on COVID-19

    Li Fu / Ancha Baranova / Hongbao Cao / Fuquan Zhang

    Frontiers in Medicine, Vol

    a Mendelian randomization study

    2023  Band 10

    Abstract: ObjectiveAlthough observational and genetic studies have indicated a correlation between OA and COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the severity of COVID-19. Here, we aimed to investigate the potential causal links ... ...

    Abstract ObjectiveAlthough observational and genetic studies have indicated a correlation between OA and COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the severity of COVID-19. Here, we aimed to investigate the potential causal links between the two.MethodsIn this study, we conducted Mendelian randomization (MR) analysis to investigate whether there is a potential causal connection between OA and COVID-19 outcomes. The analysis utilized publicly available GWAS summary datasets, incorporating data on OA (N = 455,221), SARS-CoV-2 infection (N = 2,597,856), hospitalized COVID-19 (N = 2,095,324), and critical COVID-19 (N = 1,086,211). Additionally, we performed a literature analysis to establish a molecular network connecting OA and COVID-19.ResultsThe MR analysis showed causal effects of OA on hospitalized COVID-19 (OR: 1.21, 95% CI: 1.02–1.43, p = 0.026) and critical COVID-19 (OR: 1.35, 95% CI: 1.09–1.68, p = 0.006) but not on SARS-CoV-2 infection as such (OR: 1.00, 95% CI: 0.92–1.08, p = 0.969). Moreover, the literature-based pathway analysis uncovered a set of specific genes, such as CALCA, ACE, SIRT1, TNF, IL6, CCL2, and others, that were found to mediate the association between OA and COVID-19.ConclusionOur findings indicate that OA elevates the risk of severe COVID-19. Therefore, larger efforts should be made in the prevention of COVID-19 in OA patients.
    Schlagwörter osteoarthritis ; COVID-19 ; Mendelian randomization ; GWAS ; ACE ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The Role and Clinical Relevance of Osteopontin in Allergic Airway Diseases

    Yang Liu / Li Fu / Zheng Liu

    Journal of Clinical Medicine, Vol 12, Iss 2433, p

    2023  Band 2433

    Abstract: The airway epithelium is exposed to numerous external irritants including infectious agents, environmental allergens, and atmospheric pollutants, releasing epithelial cytokines including thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 and ... ...

    Abstract The airway epithelium is exposed to numerous external irritants including infectious agents, environmental allergens, and atmospheric pollutants, releasing epithelial cytokines including thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 and initiating downstream type 2 (IL-4, IL-13, and IL-5) and IgE-driven pathways. These pathways trigger the initiation and progression of allergic airway diseases, including chronic rhinosinusitis with nasal polyps (CRSwNP), allergic rhinitis (AR), and allergic asthma. However, the use of biological agents that target downstream cytokines, such as IL-5, IL-4, and IL-13 receptors and IgE, might not be sufficient to manage some patients successfully. Instead of blocking downstream cytokines, targeting upstream epithelial cytokines has been proposed to address the complex immunologic networks associated with allergic airway diseases. Osteopontin (OPN), an extracellular matrix glyco-phosphoprotein, is a key mediator involved in Th1-related diseases, including systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis. Emerging evidence, including ours, indicates that epithelial-cell-derived OPN also plays an essential role in Th2-skewed airway diseases, including CRSwNP, AR, and allergic asthma involving the Th17 response. Therefore, we reviewed the current knowledge of epithelial-cell-derived OPN in the pathogenesis of three type-2-biased airway diseases and provided a direction for its future investigation and clinical relevance.
    Schlagwörter osteopontin ; inflammation ; biomarker ; therapeutic target ; pathogenesis ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Prognostic analysis of uveal melanoma based on the characteristic genes of M2-type macrophages in the tumor microenvironment

    Li Fu / Qun Huang / Yongfeng Wu / Diang Chen

    BMC Bioinformatics, Vol 24, Iss 1, Pp 1-

    2023  Band 15

    Abstract: Abstract Uveal melanoma arises from stromal melanocytes and is the most prevalent primary intraocular tumor in adults. It poses a significant diagnostic and therapeutic challenge due to its high malignancy and early onset of metastases. In recent years, ... ...

    Abstract Abstract Uveal melanoma arises from stromal melanocytes and is the most prevalent primary intraocular tumor in adults. It poses a significant diagnostic and therapeutic challenge due to its high malignancy and early onset of metastases. In recent years, there has been a growing interest in the role of diverse immune cells in tumor cell development and metastasis. Using The Cancer Genome Atlas and the gene expression omnibus databases, and the CIBERSORT method, we investigated the topography of intra-tumor immune infiltration in uveal melanoma in this research. We evaluated the prognosis of uveal melanoma patients using the M2 macrophage immune cell infiltration score in conjunction with clinical tumor patient data. We built a prognostic model based on the distinctive genes of M2 macrophages and combined it with patients’ clinical data in the database; we ran a survival prognostic analysis to authenticate the model’s accuracy. The functional study revealed the importance of macrophage-associated genes in the development of uveal melanoma. Moreover, the reliability of our prediction model was verified by combining tumor mutational load, immune checkpoint, and drug sensitivity, respectively. Our study provides a reference for the follow-up study of uveal melanoma.
    Schlagwörter Uveal melanoma ; M2 macrophages ; Tumor microenvironment (TME) ; The Cancer Genome Atlas (TCGA) ; Gene expression omnibus (GEO) ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: An effective treatment and suspicious adverse reaction to Ibrutinib in a patient diagnosed with splenic B-cell lymphoma/leukaemia with prominent nucleoli: A first case report.

    Shen, Mei-Xiao / Li, Fu-Ling / Luo, Xian-Sheng / Wang, Zhi-Ming

    Medicine

    2024  Band 102, Heft 52, Seite(n) e36022

    Abstract: Rationale: Splenic B-cell lymphoma/leukemia with prominent nucleoli (SBLPN) is a new classification, which is so rare that it lacks clinical data.: Patient concerns: An increased proportion of prolymphocytes (84%) in the bone marrow smear. Whole exon ...

    Abstract Rationale: Splenic B-cell lymphoma/leukemia with prominent nucleoli (SBLPN) is a new classification, which is so rare that it lacks clinical data.
    Patient concerns: An increased proportion of prolymphocytes (84%) in the bone marrow smear. Whole exon sequence analysis revealed a TP53 mutation.
    Diagnoses: Combining the clinical features with laboratory test results led to a diagnosis of SBLPN which was made according to the 5th edition of the WHO classification of hematolymphoid tumors, although the patient was diagnosed with B-PLL when guided by the 4th edition of the WHO classification.
    Interventions: The use of Ibrutinib as an effective treatment.
    Outcomes: The patient was in complete remission after 5 months of Ibrutinib and then died of sudden aortic dissection.
    Lessons: Ibrutinib was an effective regimen for SBLPN. Aortic dissection might be considered as a suspicious adverse reaction to Ibrutinib.
    Mesh-Begriff(e) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Leukemia ; Lymphoma, B-Cell ; Aortic Dissection ; Adenine/analogs & derivatives ; Piperidines
    Chemische Substanzen ibrutinib (1X70OSD4VX) ; Adenine (JAC85A2161) ; Piperidines
    Sprache Englisch
    Erscheinungsdatum 2024-01-11
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000036022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Reconstruction of Plantar Forefoot Area with Lateral Toe Pulp Flap: Case Report and Literature Review.

    Hung, Chen-Ting / Lee, Jiunn-Tat / Wu, Meng-Si / Cheng, Li-Fu

    Plastic and reconstructive surgery. Global open

    2024  Band 12, Heft 3, Seite(n) e5654

    Abstract: Reconstruction of the plantar forefoot area is challenging because it performs important functions, including carrying the body weight and balancing the ambulation gait, and lacks similar skin and soft tissues to manage the adjacent region. Herein, we ... ...

    Abstract Reconstruction of the plantar forefoot area is challenging because it performs important functions, including carrying the body weight and balancing the ambulation gait, and lacks similar skin and soft tissues to manage the adjacent region. Herein, we shared our experience of using a lateral toe pulp flap and reviewed the relevant literature on this topic. A 33-year-old man presented with a large granuloma in the left plantar forefoot area after undergoing multiple operations owing to the diagnosis of callus. After tumor excision, the wound exhibited tendon exposure and a large infected dead space in the myofascial layer. After serial debridement with negative pressure wound therapy, the wound, which measured ~3.5 × 2.5 cm
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005654
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  9. Artikel ; Online: Prognostic factors for resected cases with gallbladder carcinoma: A systematic review and meta-analysis.

    Lv, Tian-Run / Wang, Jun-Ke / Li, Fu-Yu / Hu, Hai-Jie

    International journal of surgery (London, England)

    2024  

    Abstract: Objective: Current meta-analysis was performed to systematically evaluate the potential prognostic factors for overall survival (OS) among resected cases with gallbladder carcinoma (GBC).: Methods: PubMed, EMBASE, and the Cochrane Library were ... ...

    Abstract Objective: Current meta-analysis was performed to systematically evaluate the potential prognostic factors for overall survival (OS) among resected cases with gallbladder carcinoma (GBC).
    Methods: PubMed, EMBASE, and the Cochrane Library were systematically retrieved and hazard ratio (HR) and its 95% confidence interval (CI) were directly extracted from the original study or roughly estimated via Tierney's method. Standard Parmar modifications were used to determine pooled HRs.
    Results: A total of 36 studies with 11502 cases were identified. Pooled results of univariate analyses indicated that advanced age (HR=1.02, P =0.00020), concurrent gallstone disease (HR=1.22, P =0.00200), elevated preoperative CA199 level (HR=1.93, P <0.00001), advanced T stage (HR=3.09, P <0.00001), lymph node metastasis (HR=2.78, P <0.00001), peri-neural invasion (HR=2.20, P <0.00001), lymph-vascular invasion (HR=2.37, P <0.00001), vascular invasion (HR=2.28, P <0.00001), poorly differentiated tumor (HR=3.22, P <0.00001), hepatic side tumor (HR=1.85, P <0.00001), proximal tumor (neck/cystic duct) (HR=1.78, P <0.00001), combined bile duct resection (HR=1.45, P <0.00001), and positive surgical margin (HR=2.90, P <0.00001) were well-established prognostic factors. Pathological subtypes ( P =0.53000) and postoperative adjuvant chemotherapy ( P =0.70000) were not prognostic factors. Pooled results of multi-variate analyses indicated that age, gallstone disease, preoperative CA199, T stage, lymph node metastasis, peri-neural invasion, lymph-vascular invasion, tumor differentiation status, tumor location (peritoneal side vs hepatic side), surgical margin, combined bile duct resection, and postoperative adjuvant chemotherapy were independent prognostic factors.
    Conclusion: Various prognostic factors have been identified beyond the 8th AJCC staging system. By incorporating these factors into a prognostic model, a more individualized prognostication and treatment regime would be developed. Upcoming multinational studies are required for the further refine and validation.
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001403
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Exceptional-point-enhanced phase sensing.

    Mao, Wenbo / Fu, Zhoutian / Li, Yihang / Li, Fu / Yang, Lan

    Science advances

    2024  Band 10, Heft 14, Seite(n) eadl5037

    Abstract: Optical sensors, crucial in diverse fields like gravitational wave detection, biomedical imaging, and structural health monitoring, rely on optical phase to convey valuable information. Enhancing sensitivity is important for detecting weak signals. ... ...

    Abstract Optical sensors, crucial in diverse fields like gravitational wave detection, biomedical imaging, and structural health monitoring, rely on optical phase to convey valuable information. Enhancing sensitivity is important for detecting weak signals. Exceptional points (EPs), identified in non-Hermitian systems, offer great potential for advanced sensors, given their marked response to perturbations. However, strict physical requirements for operating a sensor at EPs limit broader applications. Here, we introduce an EP-enhanced sensing platform featuring plug-in external sensors separated from an EP control unit. EPs are achieved without modifying the sensor, solely through control-unit adjustments. This configuration converts and amplifies optical phase changes into quantifiable spectral features. By separating sensing and control functions, we expand the applicability of EP enhancement to various conventional sensors. As a proof-of-concept, we demonstrate a sixfold reduction in the detection limit of fiber-optic strain sensing using this configuration. This work establishes a universal platform for applying EP enhancement to diverse phase-dependent structures, promising ultrahigh-sensitivity sensing across various applications.
    Sprache Englisch
    Erscheinungsdatum 2024-04-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adl5037
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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