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  1. Artikel: Potential causal association between aspirin use and erectile dysfunction in European population: a Mendelian randomization study.

    Li, Rongkang / Peng, Lei / Deng, Dashi / Li, Guangzhi / Wu, Song

    Frontiers in endocrinology

    2024  Band 14, Seite(n) 1329847

    Abstract: Background: Aspirin, as one of the most commonly used drugs, possesses a broad spectrum of therapeutic applications. Presently, the potential association between aspirin usage and the risk elevation of erectile dysfunction (ED) remains inconclusive. The ...

    Abstract Background: Aspirin, as one of the most commonly used drugs, possesses a broad spectrum of therapeutic applications. Presently, the potential association between aspirin usage and the risk elevation of erectile dysfunction (ED) remains inconclusive. The objective of this study employing two-sample Mendelian randomization (MR) was to clarify the causal impact of aspirin use on the risk of ED.
    Methods: This study incorporated two sets of Genome-Wide Association Study (GWAS) summary statistics, one for aspirin use (46,946 cases and 286,635 controls) and another for ED (6,175 cases and 217,630 controls) in individuals of European ancestry. The inverse-variance weighted (IVW) method was employed as the primary approach, supplemented by MR-Egger, weighted median, weighted mode, and simple mode to estimate the causal effect of aspirin usage on the risk of ED development. To assess pleiotropy, the MR-PRESSO global test and MR-Egger regression were used. Cochran's Q test was adopted to check heterogeneity, and the leave-one-out analysis was performed to confirm the robustness and reliability of the results.
    Results: The causal association between genetically inferred aspirin use and ED was found by using inverse variance weighted (OR = 20.896, 95% confidence interval = 2.077-2.102E+2, P = 0.010). The sensitivity analysis showed that no pleiotropy and heterogeneity was observed. Furthermore, the leave-one-out analysis demonstrated that the findings were not significantly affected by any instrumental variables.
    Conclusion: The results of this study highlighted the significance of aspirin use as a predisposing factor for ED and provided further evidence supporting the causal association between aspirin utilization and ED within European populations.
    Mesh-Begriff(e) Male ; Humans ; Erectile Dysfunction/chemically induced ; Erectile Dysfunction/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Reproducibility of Results ; Aspirin/adverse effects ; Causality
    Chemische Substanzen Aspirin (R16CO5Y76E)
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1329847
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Causal relationship between Alzheimer's disease and prostate cancer: a bidirectional Mendelian randomization analysis.

    Li, Rongkang / Peng, Lei / Deng, Dashi / Li, Guangzhi / Wu, Song

    Frontiers in endocrinology

    2024  Band 15, Seite(n) 1354528

    Abstract: Background: Previous observational researchers have found an inverse bidirectional link between Alzheimer's disease (AD) and prostate cancer (PCa); yet, the causative nature of this link remains unclear. To investigate the causal interactions between AD ...

    Abstract Background: Previous observational researchers have found an inverse bidirectional link between Alzheimer's disease (AD) and prostate cancer (PCa); yet, the causative nature of this link remains unclear. To investigate the causal interactions between AD and PCa, a bidirectional Mendelian randomization (MR) analysis was conducted.
    Methods: This study comprised two Genome-Wide Association Study (GWAS) summary statistics for AD (17,008 cases and 37,154 controls) and PCa (79,148 cases and 61,106 controls) in individuals of European ancestry. The inverse-variance weighted (IVW) method was employed as the primary approach, while MR-Egger, weighted median, weighted mode, and simple mode served as supplementary methods for estimating the causal effect. To assess pleiotropy, the MR-PRESSO global test and MR-Egger regression were used. Cochran's Q test was adopted to check heterogeneity, MR Steiger test and the leave-one-out analysis was performed to confirm the robustness and reliability of the results.
    Results: The causal association genetically inferred of AD on PCa was found using IVW (OR = 0.974, 95% CI = 0.958-0.991, p = 0.003) in forward MR analysis and the causal association genetically inferred of PCa on AD was not found using IVW (OR = 1.000, 95% CI: 0.954-1.049, P = 0.988) in reverse MR analysis. The sensitivity analysis showed that no pleiotropy and heterogeneity was observed. The leave-one-out analysis showed that the findings were not inordinately affected by any instrumental variables.
    Conclusion: The results of this study demonstrated an absence of bidirectional causality between AD and PCa among the European population, suggested that a genetically predicted possibility of decreased PCa risk in AD patients, and no significant genetically predicted causal effect of PCa on AD.
    Mesh-Begriff(e) Male ; Humans ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Reproducibility of Results ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics
    Sprache Englisch
    Erscheinungsdatum 2024-03-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1354528
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Effect of quick acupuncture combined with rehabilitation therapy on improving motor and swallowing function in patients with stroke.

    Ma, Yinfei / Guo, Hairui / Geng, Lijuan / Jia, Zhongfen / Li, Guangzhi / Shen, Wei / Wang, Jianyu

    Clinical rehabilitation

    2024  Band 38, Heft 6, Seite(n) 793–801

    Abstract: Objective: To investigate the effect of quick acupuncture combined with rehabilitation therapy on motor and swallowing function of patients with stroke.: Design: A retrospective study.: Setting: Single center study.: Participants: One hundred ... ...

    Abstract Objective: To investigate the effect of quick acupuncture combined with rehabilitation therapy on motor and swallowing function of patients with stroke.
    Design: A retrospective study.
    Setting: Single center study.
    Participants: One hundred and twenty patients with stroke were divided into control and observation group based on the therapeutic regimen.
    Intervention: Control group (n = 60) only received rehabilitation therapy, and observation group (n = 60) received rehabilitation therapy combined with quick acupuncture. Acupuncture was performed once a day, and 6 times/week for 4 consecutive weeks.
    Main measures: The simplified Fugl-Meyer assessment scale and Barthel index were used to assess limb motor function and daily living ability. The Dysphagia Outcome Severity Scale and Swallowing Quality of Life questionnaire were conducted to estimate the dysphagia severity and life quality of patients with swallowing disorders. The therapeutic efficacy and complications after treatment were analyzed and counted.
    Results: After treatment, the scores of the observation group were significantly improved compared with the control group (
    Conclusion: This study suggests that rehabilitation therapy combined with rapid acupuncture therapy has a potential therapeutic effect on the relief of swallowing and motor dysfunction after stroke.
    Mesh-Begriff(e) Humans ; Male ; Female ; Stroke Rehabilitation/methods ; Acupuncture Therapy/methods ; Middle Aged ; Deglutition Disorders/rehabilitation ; Deglutition Disorders/etiology ; Retrospective Studies ; Stroke/complications ; Aged ; Treatment Outcome ; Combined Modality Therapy ; Quality of Life ; Recovery of Function ; Severity of Illness Index
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 639276-3
    ISSN 1477-0873 ; 0269-2155
    ISSN (online) 1477-0873
    ISSN 0269-2155
    DOI 10.1177/02692155241228694
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The Current Status of Photodynamic Therapy in Cancer Treatment.

    Jiang, Wenqi / Liang, Mingkang / Lei, Qifang / Li, Guangzhi / Wu, Song

    Cancers

    2023  Band 15, Heft 3

    Abstract: Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic therapy (PDT), a non-invasive therapeutic approach, has attracted much ... ...

    Abstract Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic therapy (PDT), a non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance in cancer therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well as oxygen dependence, largely limit its therapeutic efficiency for solid tumors treatment. Thus, numerous strategies have gone into overcoming these obstacles, such as exploring new photosensitizers with higher photodynamic conversion efficiency, alleviating tumor hypoxia to fuel the generation of reactive oxygen species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, we briefly summarized the PDT related tumor therapeutic approaches, which are mainly characterized by advanced PSs, these PSs have excellent conversion efficiency and additional refreshing features. We also briefly summarize PDT-based combination therapies with excellent therapeutic effects.
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030585
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Hypochlorous Acid-Activated UCNPs-LMB/VQIVYK Multifunctional Nanosystem for Alzheimer's Disease Treatment.

    Qiao, Luying / Shen, Yang / Li, Guangzhi / Lv, Guanglei / Li, Chunxia

    Journal of functional biomaterials

    2023  Band 14, Heft 4

    Abstract: The development of nanosystems, which can photooxygenate amyloid-β (Aβ), detect the Tau protein, and inhibit effectively the Tau aggregation, is increasingly important in the diagnosis and therapy of Alzheimer's disease (AD). Herein, UCNPs-LMB/VQIVYK ( ... ...

    Abstract The development of nanosystems, which can photooxygenate amyloid-β (Aβ), detect the Tau protein, and inhibit effectively the Tau aggregation, is increasingly important in the diagnosis and therapy of Alzheimer's disease (AD). Herein, UCNPs-LMB/VQIVYK (UCNPs: upconversion nanoparticles, LMB: Leucomethylene blue, and VQIVYK: Biocompatible peptide) is designed as a HOCl-controlled released nanosystem for AD synergistic treatment. Under exposure to high levels of HOCl, the released MB from UCNPs-LMB/VQIVYK will produce singlet oxygen (
    Sprache Englisch
    Erscheinungsdatum 2023-04-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14040207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Clinical Efficacy of Different Doses of Canagliflozin Combined with Metformin in the Treatment of Type 2 Diabetes: Meta-Analysis.

    Li, GuangZhi / Zhang, Dongmei / Ni, Jie / Wang, Shizhen

    Alternative therapies in health and medicine

    2023  Band 29, Heft 7, Seite(n) 328–334

    Abstract: Background: With social development, an aging population, and the increasing trend of obesity, type 2 diabetes (T2DM) has become one of the major problems affecting human health across the globe.: Methods: Information on controlled trials was ... ...

    Abstract Background: With social development, an aging population, and the increasing trend of obesity, type 2 diabetes (T2DM) has become one of the major problems affecting human health across the globe.
    Methods: Information on controlled trials was retrieved from four databases to obtain the effects of different doses of canagliflozin combined with metformin for treating T2DM. After a rigorous evaluation of the quality of the literature, data analysis was performed using RevMan 5.3 software.
    Results: We included 8 studies in this meta-analysis. The least square (LS) means of HbA1c and FPG in the test group were statistically lower than the control group. Our analysis revealed that the adverse reactions were not significantly different between the experimental and control groups (OR: 1.03; 95% Cl: 0.94, 1.12; P = .555). Also, we found that the urinary tract infection of the experimental group was not statistically different from the control group (OR: 0.94; 95% Cl: 0.71, 1.24; P = .648). Moreover, we identified that the blood pressure and blood lipids of the experimental group did not statistically differ from the control group.
    Conclusion: The meta-analysis demonstrates that high doses of canagliflozin combined with metformin may be potentially effective in patients with T2DM, as evidenced by LS means of HbA1c and FPG, and the above conclusions need to be verified by more high-quality studies.
    Mesh-Begriff(e) Aged ; Humans ; Blood Glucose ; Canagliflozin/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin ; Hypoglycemic Agents/therapeutic use ; Metformin/therapeutic use ; Treatment Outcome
    Chemische Substanzen Blood Glucose ; Canagliflozin (0SAC974Z85) ; Glycated Hemoglobin ; Hypoglycemic Agents ; Metformin (9100L32L2N)
    Sprache Englisch
    Erscheinungsdatum 2023-07-25
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4504: Hefte anzeigen Standort:
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  7. Artikel ; Online: Epigenetic inhibition of lncRNA GMDS-AS1 by methyltransferase ESET promoted cell viability and metastasis of hepatocellular carcinoma.

    Huang, Junling / Zhong, Tengmeng / Li, Guangzhi / Wang, Shuzhen / Qin, Rujuan

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Band 25, Heft 6, Seite(n) 1793–1804

    Abstract: Background: Long noncoding RNA (lncRNAs) GMDS-AS1 has been reported as a tumor regulator in tumor growth and metastasis, but its effect in hepatocellular carcinoma (HCC) remains unclear. ESET, a histone H3K9 methyl-transferase, is involved in epigenomic ...

    Abstract Background: Long noncoding RNA (lncRNAs) GMDS-AS1 has been reported as a tumor regulator in tumor growth and metastasis, but its effect in hepatocellular carcinoma (HCC) remains unclear. ESET, a histone H3K9 methyl-transferase, is involved in epigenomic regulation of tumor progression in multiple cancers. However, the correlation between ESET and lncRNA in HCC is less reported.
    Methods: Quantitative real-time PCR (qRT-PCR) was taken to determine the expression of ESET and GMDS-AS1. Western blot was taken to determine the target protein levels of ESET and GMDS-AS1. Online database and bioinformatics analysis were used to screen abnormally expressed genes. Luciferase assay was performed to confirm the binding of GMDS-AS1 and PSMB1. Ki67 and Edu were used for evaluated the proliferation of tumor cells. ChIP assay was performed to verify the relationship between H3K9me1 and lncRNA GMDS-AS1 promoter. Transwell was taken to determine the migration and invasion ability of tumor cells. CCK-8 was used for determining the viability of tumor cells. Flow cytometry was performed to detect the cell cycle of tumor cells.
    Results: The expression of GMDS-AS1 was decreased and the expression of ESET was increased in HCC. GMDS-AS1 inhibition contributed to tumor development, and this effect was closely related to epigenetic inhibition of GMDS-AS1 by ESET. PSMB1, a downstream target of GMDS-AS1, promoted the tumor proliferation and was negatively regulated by GMDS-AS1.
    Conclusion: Our result demonstrates anti-tumorigenic traits of lncRNA GMDS-AS1 in HCC and explains its pattern of regulation mediated by ESET. Our work unmasked an essential role of GMDS-AS1 in HCC progression and detected a novel pathway for ESET to promote HCC.
    Mesh-Begriff(e) Humans ; Carcinoma, Hepatocellular/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Liver Neoplasms/pathology ; Cell Survival ; Methyltransferases/genetics ; Epigenomics ; Cell Proliferation/genetics ; MicroRNAs/genetics ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cell Movement/genetics
    Chemische Substanzen RNA, Long Noncoding ; Methyltransferases (EC 2.1.1.-) ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2023-02-03
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03077-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6644: Hefte anzeigen Standort:
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  8. Artikel: Functional Nanoparticles for Enhanced Cancer Therapy.

    Li, Chenchen / Li, Yuqing / Li, Guangzhi / Wu, Song

    Pharmaceutics

    2022  Band 14, Heft 8

    Abstract: Cancer is the leading cause of death in people worldwide. The conventional therapeutic approach is mainly based on chemotherapy, which has a series of side effects. Compared with traditional chemotherapy drugs, nanoparticle-based delivery of anti-cancer ... ...

    Abstract Cancer is the leading cause of death in people worldwide. The conventional therapeutic approach is mainly based on chemotherapy, which has a series of side effects. Compared with traditional chemotherapy drugs, nanoparticle-based delivery of anti-cancer drugs possesses a few attractive features. The application of nanotechnology in an interdisciplinary manner in the biomedical field has led to functional nanoparticles achieving much progress in cancer therapy. Nanoparticles have been involved in the diagnosis and targeted and personalized treatment of cancer. For example, different nano-drug strategies, including endogenous and exogenous stimuli-responsive, surface conjugation, and macromolecular encapsulation for nano-drug systems, have successfully prevented tumor procession. The future for functional nanoparticles is bright and promising due to the fast development of nanotechnology. However, there are still some challenges and limitations that need to be considered. Based on the above contents, the present article analyzes the progress in developing functional nanoparticles in cancer therapy. Research gaps and promising strategies for the clinical application are discussed.
    Sprache Englisch
    Erscheinungsdatum 2022-08-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14081682
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Advances in Diagnosis and Therapy for Bladder Cancer.

    Hu, Xinzi / Li, Guangzhi / Wu, Song

    Cancers

    2022  Band 14, Heft 13

    Abstract: Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous ... ...

    Abstract Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. The development of innovative enhanced cystoscopy techniques (optical techniques, imaging systems) and tumor biomarkers-based non-invasive urine screening (DNA methylation-based urine test) would dramatically improve the accuracy of tumor detection, reducing the risk of recurrence and progression of BCa. Moreover, intravesical instillation and systemic therapeutic strategies (cocktail therapy, immunotherapy, vaccine therapy, targeted therapy) also provide plentiful measures to break the predicament of BCa. Several exploratory clinical studies, including novel surgical approaches, pharmaceutical compositions, and bladder preservation techniques, emerged continually, which are supposed to be promising candidates for BCa clinical treatment. Here, recent advances and prospects of diagnosis, intravesical or systemic treatment, and novel drug delivery systems for BCa therapy are reviewed in this paper.
    Sprache Englisch
    Erscheinungsdatum 2022-06-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133181
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Protective Role of Taraxasterol against Cardiovascular Aging and Aging-Induced Desensitization of Insulin Signaling.

    Li, Guangzhi / Zhang, Dongmei / Wang, Shizhen / Jie, Ni / Qin, Yongting

    Frontiers in bioscience (Landmark edition)

    2022  Band 27, Heft 11, Seite(n) 311

    Abstract: Background: Cardiovascular disease (CVD) has become one of the leading causes of death and disability worldwide, and its incidence continues to increase because of an aging population. Studies have shown that the function of cardiomyocytes decreases ... ...

    Abstract Background: Cardiovascular disease (CVD) has become one of the leading causes of death and disability worldwide, and its incidence continues to increase because of an aging population. Studies have shown that the function of cardiomyocytes decreases during aging, leading to changes in the functional and structural integrity of the heart, ultimately resulting in CVD. The decrease in the number of functional cardiomyocytes has a negative impact on cardiac function; thus, myocardial aging is one of the main factors that causes heart-related diseases (such as CVD). Therefore, alleviating cardiac aging is one of the main ways of treating aging-related cardiac diseases. In this study, we evaluated the potential effect of taraxasterol on myocardial aging.
    Methods: The effect of taraxasterol on the aging of cardiomyocytes was analyzed
    Results: The experimental results indicated that taraxasterol could reduce cardiomyocyte senescence, which was evaluated using Sa-β-gal staining and senescence-related marker molecules (e.g., p16 and p21). We found that taraxasterol could significantly alleviate cardiomyocyte senescence in the
    Conclusions: Taken together, this work illustrated that taraxasterol could reduce cardiac aging and fibrosis and enhance insulin signaling sensitivity, indicating that taraxasterol may be an effective drug or health food additive for treating cardiac aging and fibrosis.
    Sprache Englisch
    Erscheinungsdatum 2022-11-22
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2711311
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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