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  1. Artikel ; Online: Managing the Transition to Widespread Metagenomic Monitoring: Policy Considerations for Future Biosurveillance.

    Liang, Chelsea / Wagstaff, James / Aharony, Noga / Schmit, Virginia / Manheim, David

    Health security

    2023  Band 21, Heft 1, Seite(n) 34–45

    Abstract: The technological possibilities and future public health importance of metagenomic sequencing have received extensive attention, but there has been little discussion about the policy and regulatory issues that need to be addressed if metagenomic ... ...

    Abstract The technological possibilities and future public health importance of metagenomic sequencing have received extensive attention, but there has been little discussion about the policy and regulatory issues that need to be addressed if metagenomic sequencing is adopted as a key technology for biosurveillance. In this article, we introduce metagenomic monitoring as a possible path to eventually replacing current infectious disease monitoring models. Many key enablers are technological, whereas others are not. We therefore highlight key policy challenges and implementation questions that need to be addressed for "widespread metagenomic monitoring" to be possible. Policymakers must address pitfalls like fragmentation of the technological base, private capture of benefits, privacy concerns, the usefulness of the system during nonpandemic times, and how the future systems will enable better response. If these challenges are addressed, the technological and public health promise of metagenomic sequencing can be realized.
    Mesh-Begriff(e) Humans ; Biosurveillance ; Communicable Diseases ; Public Health ; Health Policy
    Sprache Englisch
    Erscheinungsdatum 2023-01-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2823049-8
    ISSN 2326-5108 ; 2326-5094
    ISSN (online) 2326-5108
    ISSN 2326-5094
    DOI 10.1089/hs.2022.0029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Comparative genomics of Chinese and international isolates of

    Luo, Lijuan / Wang, Hong / Payne, Michael J / Liang, Chelsea / Bai, Li / Zheng, Han / Zhang, Zhengdong / Zhang, Ling / Zhang, Xiaomei / Yan, Guodong / Zou, Nianli / Chen, Xi / Wan, Ziting / Xiong, Yanwen / Lan, Ruiting / Li, Qun

    Microbial genomics

    2021  Band 7, Heft 12

    Abstract: Escherichia ... ...

    Abstract Escherichia albertii
    Mesh-Begriff(e) Africa ; Animals ; Canada ; China ; Drug Resistance, Multiple, Bacterial ; Escherichia/classification ; Escherichia/drug effects ; Escherichia/genetics ; Escherichia/pathogenicity ; Europe ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Phylogeny ; Plasmids/genetics ; Poultry/microbiology ; Prophages/genetics ; Sequence Analysis, DNA/methods ; United States ; Virulence Factors/genetics
    Chemische Substanzen Virulence Factors
    Sprache Englisch
    Erscheinungsdatum 2021-12-09
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000710
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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