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  1. Artikel ; Online: A new variant of gallbladder duplication mimicking a choledochal cyst: stepwise management of an unexpected surgical finding.

    Kim, M / Lam, S / Thirunavaya Kalathil, M A / Paterson, A / Bowden, D J / Liau, S-S

    Annals of the Royal College of Surgeons of England

    2024  

    Abstract: We present a case of previously unclassified duplicated gallbladder which posed a surgical challenge intraoperatively by mimicking a choledochal cyst. An intraoperative cholangiogram was performed followed by a simple cholecystectomy. No further ... ...

    Abstract We present a case of previously unclassified duplicated gallbladder which posed a surgical challenge intraoperatively by mimicking a choledochal cyst. An intraoperative cholangiogram was performed followed by a simple cholecystectomy. No further dissection was performed to avoid bile duct injury and complication from the unconventional anatomy. Postoperative imaging and histology, followed by the second operation confirmed findings consistent with the duplicated gallbladder. Through this case, we have demonstrated the principles of safe cholecystectomy and the importance of a staged approach in an unanticipated encounter of anatomical uncertainty, as well as the description of a new variant of duplicated gallbladder.
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2022.0131
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  2. Artikel ; Online: Improvised biliary cooling technique for radiofrequency ablation of liver tumours close to central bile ducts.

    Elshaer, M / White, J / Liau, S S

    Annals of the Royal College of Surgeons of England

    2020  Band 102, Heft 9, Seite(n) 758

    Mesh-Begriff(e) Common Bile Duct/physiology ; Humans ; Hypothermia, Induced/methods ; Laparotomy ; Liver/surgery ; Liver Neoplasms/surgery ; Radiofrequency Ablation/methods
    Sprache Englisch
    Erscheinungsdatum 2020-08-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2020.0187
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  3. Artikel ; Online: An update on inflammation in uveal melanoma.

    Liau, Sebastian / Wang, Janney Z / Zagarella, Ethan / Paulus, Paus / Dang, Nguyen Huong Que Hiep / Rawling, Tristan / Murray, Michael / Zhou, Fanfan

    Biochimie

    2023  Band 212, Seite(n) 114–122

    Abstract: Uveal melanoma (UM) is the primary ocular cancer with upto 50% of patients dying from metastasis. Although rare, it is deadly as patients with metastatic UM seldom survive beyond 18 months after diagnosis. Chemotherapeutics have no proven efficacy, ... ...

    Abstract Uveal melanoma (UM) is the primary ocular cancer with upto 50% of patients dying from metastasis. Although rare, it is deadly as patients with metastatic UM seldom survive beyond 18 months after diagnosis. Chemotherapeutics have no proven efficacy, including immunotherapies that have been tried as current treatment options but produce marginal improvement in overall survival for UM patients. While therapeutics are low in efficacy, there is an urgent need to explore novel targets in the treatment of UM. This review provides an update on the contribution of inflammation to UM with a focus on exploring potential therapeutic targets related to the inflammatory tumour microenvironment. As a tumour promoting event, inflammation is one of the hallmarks of cancers. The presence of the inflammatory phenotype characterised by the abundance of immune mediators and proinflammatory cytokines surrounding UM tumours, is a potential area to explore novel therapeutic targets. Despite decades of investigation regarding the role UM tumour microenvironment has played, that of inflammation in UM progression remains poorly understood. With advancement of technologies, an understanding of the prognosis of UM has been accelerated. Excitingly, novel therapeutic targets related to the inflammatory tumour microenvironment have been identified and relevant studies are underway in their preliminary phases, illustrating optimistic results.
    Mesh-Begriff(e) Humans ; Melanoma/therapy ; Uveal Neoplasms/therapy ; Uveal Neoplasms/genetics ; Prognosis ; Inflammation ; Tumor Microenvironment
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland France
    Dokumenttyp Journal Article ; Review
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2023.04.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Combined transversus abdominis plane and rectus sheath catheters for postoperative analgesia following major hepatopancreatobiliary surgery.

    van Laarhoven, S / Janssen, B / Liau, S S

    Annals of the Royal College of Surgeons of England

    2019  Band 102, Heft 1, Seite(n) 71–72

    Mesh-Begriff(e) Abdominal Muscles/surgery ; Biliary Tract Surgical Procedures/adverse effects ; Catheters ; Humans ; Pain Management/instrumentation ; Pain Management/methods ; Pain, Postoperative/prevention & control ; Pain, Postoperative/therapy ; Rectus Abdominis/surgery
    Sprache Englisch
    Erscheinungsdatum 2019-09-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2019.0094
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Biliary cooling during radiofrequency ablation of liver tumours close to central biliary tree: A systematic review and pooled analysis.

    Feretis, M / Wang, Y / Zhang, B / Liau, S-S

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2020  Band 47, Heft 4, Seite(n) 743–747

    Abstract: Introduction: Biliary cooling during radiofrequency ablation (RFA) of liver tumour has been proposed as a protective measure for RFA-related biliary complications in cases whereby the RFA site is close to central biliary tree. This systematic review ... ...

    Abstract Introduction: Biliary cooling during radiofrequency ablation (RFA) of liver tumour has been proposed as a protective measure for RFA-related biliary complications in cases whereby the RFA site is close to central biliary tree. This systematic review aims to assess the effect of biliary cooling during RFA on: 1) the development of biliary complications and 2) tumour recurrence rates at ablation site.
    Methodology: A systematic literature search was performed using the PubMed/EMBASE databases using PRISMA methodology (2000-2019). The initial search yielded 75 reports which were potentially suitable for inclusion. Studies reporting at least one outcome of interest were considered to be suitable for inclusion. Conference abstracts, case reports and animal studies were excluded. Data was retrieved from each study on patient demographics, tumour characteristics, method of cooling, biliary complications, local tumour recurrence and duration of follow-up.
    Results: The final number of studies which met the inclusion criteria was 7, involving 100 patients. There were no randomized controlled trials identified after the literature search. The mean age of the patients included was 65 years. Biliary cooling was performed with the use of a nasobiliary tube in 4 out of 7 studies, via a choledochal incision in 2 out of 7 studies and through the cystic duct in a single study. The overall biliary stricture rate was 2% and the overall tumour recurrence rate at RFA treated site was 14.5%.
    Conclusion: Biliary complications appear to be low after biliary cooling during RFA close to central biliary tree. More evidence is required to assess the tumour recurrence rates.
    Mesh-Begriff(e) Bile Ducts/diagnostic imaging ; Bile Ducts/pathology ; Biliary Tract ; Constriction, Pathologic/diagnostic imaging ; Constriction, Pathologic/etiology ; Humans ; Hypothermia, Induced ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Neoplasm Recurrence, Local ; Radiofrequency Ablation/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2020-09-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Systematic Review
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2020.09.033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Preoperative diagnosis of intraductal papillary neoplasm of the bile duct with endoscopic ultrasound.

    Ramzi, J / Feretis, M / Hickman, K E / Martin, J L / Godfrey, E / Liau, S S

    Annals of the Royal College of Surgeons of England

    2021  Band 103, Heft 2, Seite(n) e65–e68

    Abstract: Intraductal papillary mucinous neoplasm of the bile duct is a rare tumour only recently classified as a distinct pathological entity. These neoplasms, rarely encountered in clinical practice in the UK, are now considered to be important precursors for ... ...

    Abstract Intraductal papillary mucinous neoplasm of the bile duct is a rare tumour only recently classified as a distinct pathological entity. These neoplasms, rarely encountered in clinical practice in the UK, are now considered to be important precursors for the development of cholangiocarcinoma. We present a histologically confirmed case of intraductal papillary neoplasm of the bile duct in a male patient and discuss the main radiographic manifestations of this rare condition across multiple imaging modalities, with an emphasis on the imaging features of endoscopic ultrasonography and its role in establishing the diagnosis.
    Mesh-Begriff(e) Adenocarcinoma, Mucinous/diagnosis ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/surgery ; Adenocarcinoma, Papillary/diagnosis ; Adenocarcinoma, Papillary/pathology ; Adenocarcinoma, Papillary/surgery ; Aged ; Anatomic Variation ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/abnormalities ; Bile Ducts, Intrahepatic/diagnostic imaging ; Bile Ducts, Intrahepatic/pathology ; Bile Ducts, Intrahepatic/surgery ; Cholangiopancreatography, Endoscopic Retrograde ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Endosonography ; Hepatectomy/methods ; Humans ; Incidental Findings ; Male ; Preoperative Care/methods ; Tomography, X-Ray Computed ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2021-02-03
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2020.7010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The FRAIL-NH Scale: Systematic Review of the Use, Validity and Adaptations for Frailty Screening in Nursing Homes.

    Liau, S J / Lalic, S / Visvanathan, R / Dowd, L A / Bell, J S

    The journal of nutrition, health & aging

    2021  Band 25, Heft 10, Seite(n) 1205–1216

    Abstract: Objectives: To investigate frailty prevalence, cross-sectional associations, predictive validity, concurrent validity, and cross-cultural adaptations of the FRAIL-NH scale.: Design: Systematic review.: Setting and participants: Frail residents ... ...

    Abstract Objectives: To investigate frailty prevalence, cross-sectional associations, predictive validity, concurrent validity, and cross-cultural adaptations of the FRAIL-NH scale.
    Design: Systematic review.
    Setting and participants: Frail residents living in nursing homes.
    Methods: MEDLINE, EMBASE, CINAHL, and Cochrane Library were searched from January 2015 to June 2021 for primary studies that used the FRAIL-NH scale, irrespective of study designs and publication language.
    Results: Overall, 40 studies conducted across 20 countries utilized the FRAIL-NH scale; majority in Australia (n=14), followed by China (n=6), United States (n=3), and Spain (n=3). The scale has been translated and back-translated into Brazilian Portuguese, Chinese, and Japanese. Various cut-offs have been used, with ≥2 and ≥6 being the most common cut-offs for frail and most frail, respectively. When defined using these cut-offs, frailty prevalence varied from 15.1-79.5% (frail) to 28.5-75.0% (most frail). FRAIL-NH predicted falls (n=2), hospitalization or length of stay (n=4), functional or cognitive decline (n=4), and mortality (n=9) over a median follow-up of 12 months. FRAIL-NH has been compared to 16 other scales, and was correlated with Fried's phenotype (FP), Frailty Index (FI), and FI-Lab. Four studies reported fair-to-moderate agreements between FRAIL-NH and FI, FP, and the Comprehensive Geriatric Assessment. Ten studies assessed the sensitivity and specificity of different FRAIL-NH cut-offs, with ≥8 having the highest sensitivity (94.1%) and specificity (82.8%) for classifying residents as frail based on FI, while two studies reported an optimal cut-off of ≥2 based on FI and FP, respectively.
    Conclusion: In seven years, the FRAIL-NH scale has been applied in 20 countries and adapted into three languages. Despite being applied with a range of cut-offs, FRAIL-NH was associated with higher care needs and demonstrated good agreement with other well-established but more complex scales. FRAIL-NH was predictive of adverse outcomes across different settings, highlighting its value in guiding care for frail residents in nursing homes.
    Mesh-Begriff(e) Aged ; Cross-Sectional Studies ; Frail Elderly ; Frailty/diagnosis ; Geriatric Assessment ; Humans ; Nursing Homes
    Sprache Englisch
    Erscheinungsdatum 2021-11-09
    Erscheinungsland France
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2081921-3
    ISSN 1760-4788 ; 1279-7707
    ISSN (online) 1760-4788
    ISSN 1279-7707
    DOI 10.1007/s12603-021-1694-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Comprehensive classification of anatomical variants of the main biliary ducts.

    Janssen, B V / van Laarhoven, S / Elshaer, M / Cai, H / Praseedom, R / Wang, T / Liau, S-S

    The British journal of surgery

    2021  Band 108, Heft 5, Seite(n) 458–462

    Mesh-Begriff(e) Bile Ducts/abnormalities ; Classification ; Humans
    Sprache Englisch
    Erscheinungsdatum 2021-03-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znaa147
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Colorectal liver metastases: Current management and future perspectives.

    Martin, Jack / Petrillo, Angelica / Smyth, Elizabeth C / Shaida, Nadeem / Khwaja, Samir / Cheow, H K / Duckworth, Adam / Heister, Paula / Praseedom, Raaj / Jah, Asif / Balakrishnan, Anita / Harper, Simon / Liau, Siong / Kosmoliaptsis, Vasilis / Huguet, Emmanuel

    World journal of clinical oncology

    2021  Band 11, Heft 10, Seite(n) 761–808

    Abstract: The liver is the commonest site of metastatic disease for patients with colorectal cancer, with at least 25% developing colorectal liver metastases (CRLM) during the course of their illness. The management of CRLM has evolved into a complex field ... ...

    Abstract The liver is the commonest site of metastatic disease for patients with colorectal cancer, with at least 25% developing colorectal liver metastases (CRLM) during the course of their illness. The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology (cross sectional, nuclear medicine and interventional), Oncology, Liver surgery, Colorectal surgery, and Histopathology. Patient management is based on assessment of sophisticated clinical, radiological and biomarker information. Despite incomplete evidence in this very heterogeneous patient group, maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure. To this end, liver resection is maximised by the use of downsizing chemotherapy, optimisation of liver remnant by portal vein embolization, associating liver partition and portal vein ligation for staged hepatectomy, and combining resection with ablation, in the context of improvements in the functional assessment of the future remnant liver. Liver resection may safely be carried out laparoscopically or open, and synchronously with, or before, colorectal surgery in selected patients. For unresectable patients, treatment options including systemic chemotherapy, targeted biological agents, intra-arterial infusion or bead delivered chemotherapy, tumour ablation, stereotactic radiotherapy, and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability. Currently evolving areas include biomarker characterisation of tumours, the development of novel systemic agents targeting specific oncogenic pathways, and the potential re-emergence of radical surgical options such as liver transplantation.
    Sprache Englisch
    Erscheinungsdatum 2021-01-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2587357-X
    ISSN 2218-4333
    ISSN 2218-4333
    DOI 10.5306/wjco.v11.i10.761
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A rational approach to postoperative surveillance for resected non-functional pancreatic neuro-endocrine tumours.

    Feretis, M / Wang, T / Ghorani, E / Balakrishnan, A / Harper, S J / Jah, A / Huguet, E L / Praseedom, R K / Liau, S-S

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2019  Band 19, Heft 7, Seite(n) 1000–1007

    Abstract: Background: Non-functional pancreatic neuroendocrine tumours (NF-PNETs) are rare and have highly variable outcomes. Current guidelines recommend surveillance for NF-PNETs <2 cm. Patients who ultimately have surgical resection are at risk of disease ... ...

    Abstract Background: Non-functional pancreatic neuroendocrine tumours (NF-PNETs) are rare and have highly variable outcomes. Current guidelines recommend surveillance for NF-PNETs <2 cm. Patients who ultimately have surgical resection are at risk of disease recurrence, and data to support postoperative surveillance protocols are lacking. The aims of this study were to i) identify post-operative predictors of recurrence and ii) risk stratify patients at risk of recurrence.
    Methods: Consecutive patients who underwent surgery for NF-PNETs between 2002 and 2015 were identified retrospectively. Data were collected on demographics, pre-operative laboratory results and histopathological tumour characteristics. Statistical analyses were based on penalised Cox-regression modelling and a decision-tree model. Comparison of the variables identified was performed using ROC curves to identify the most sensitive and specific variable associated with disease recurrence.
    Results: We identified 73 patients (38 males) with a median age of 61.5 years (range: 31-79). The median period of follow-up was 49 months (5-131). During follow up, 10 deaths (13.9%) were recorded and disease recurrence occurred in 12 patients (16.4%). The Kaplan-Meier predicted 1-,3- and 5-year recurrence-free survival rates were 98.6% (95% CI = 95.9, 100%), 85.4% (76.9-94.8%) and 72% (58.7-88.2%) respectively. Cox multivariate analysis identified poor tumour differentiation (WHO G3 grade) and lymph node ratio (LNR) as independent predictors for recurrence (p < 0.05). A simple criterion of 'tumour grade G3 or LNR ≥0.1' was found to be sensitive and specific in detecting disease recurrence.
    Conclusion: Our results have identified a simple and sensitive criterion for risk stratifying post-resection surveillance. Prospective validation in larger patient cohort is now warranted.
    Mesh-Begriff(e) Adult ; Aged ; Disease-Free Survival ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/pathology ; Neuroendocrine Tumors/surgery ; Odds Ratio ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Postoperative Care ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2019-08-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2019.08.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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