Artikel ; Online: Potential mechanism of transient receptor potential cation channel subfamily V member 1 combined with an ATP‑sensitive potassium channel in severe preeclampsia.
Experimental and therapeutic medicine
2023 Band 26, Heft 1, Seite(n) 318
Abstract: Severe preeclampsia is one of the most serious obstetric diseases. However, the pathogenesis of the disease is not fully understood. In the present study, placental artery and blood serum was collected from patients with severe preeclampsia, as well as ... ...
Abstract | Severe preeclampsia is one of the most serious obstetric diseases. However, the pathogenesis of the disease is not fully understood. In the present study, placental artery and blood serum was collected from patients with severe preeclampsia, as well as from normal pregnant women. The results of reverse transcription-quantitative (q)PCR, western blotting, and immunohistochemical staining revealed markedly decreased transient receptor potential cation channel subfamily V member 1 (TRPV1), ATP-sensitive potassium channel (KATP) subtype Kir6.1/SUR2B and endothelial nitric oxide synthase (eNOS) expression in severe preeclampsia tissue specimens compared with those in samples from normal pregnant women. The nitrate reduction method indicated lower NO levels in the tissue specimens and serum of patients with severe preeclampsia. Moreover, hematoxylin-eosin staining showed that the endothelial cell layer in the placental artery of patients with severe preeclampsia was notably damaged. To investigate the potential role of TRPV1-KATP channels in severe preeclampsia, HUVECs were used for |
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Sprache | Englisch |
Erscheinungsdatum | 2023-05-15 |
Erscheinungsland | Greece |
Dokumenttyp | Journal Article |
ZDB-ID | 2683844-8 |
ISSN | 1792-1015 ; 1792-0981 |
ISSN (online) | 1792-1015 |
ISSN | 1792-0981 |
DOI | 10.3892/etm.2023.12017 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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