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  1. Artikel: Arabidopsis Leaf Chloroplasts Have a Specific Sphingolipidome.

    Yang, Chang / Wang, Ling-Yan / Li, Yong-Kang / Lin, Jia-Ting / Chen, Ding-Kang / Yao, Nan

    Plants (Basel, Switzerland)

    2024  Band 13, Heft 2

    Abstract: Sphingolipids are ubiquitous in eukaryotes and certain prokaryotes, where they serve as vital components of biological membranes and bioactive molecules. Chloroplasts have complex membrane structures that play crucial roles in photosynthesis, but their ... ...

    Abstract Sphingolipids are ubiquitous in eukaryotes and certain prokaryotes, where they serve as vital components of biological membranes and bioactive molecules. Chloroplasts have complex membrane structures that play crucial roles in photosynthesis, but their specific sphingolipidome remains unreported. In this study, we used liquid chromatography-mass spectrometry (LC-MS/MS) to analyze the sphingolipidome of purified
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13020299
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: NAMPT/SIRT1 Expression Levels in White Blood Cells Differentiate the Different Rheumatoid Arthritis Subsets: An Inspiration from Traditional Chinese Medicine.

    Cheng, Xiu-Ping / Wang, Xiao-Wan / Sun, Han-Fei / Xu, Liang / Olatunji, Opeyemi Joshua / Li, Yan / Lin, Jia-Ting / Zuo, Jian

    Journal of inflammation research

    2023  Band 16, Seite(n) 4271–4285

    Abstract: Background: Rheumatoid arthritis (RA) patients are prone to developing different metabolic complications. Traditional Chinese Medicine attributes this uncertainty to varied syndrome types.: Methods and results: We retrospectively analyzed some ... ...

    Abstract Background: Rheumatoid arthritis (RA) patients are prone to developing different metabolic complications. Traditional Chinese Medicine attributes this uncertainty to varied syndrome types.
    Methods and results: We retrospectively analyzed some serological indicators of active RA patients and healthy individuals. Randomly selected RA patients were divided into three groups according to
    Conclusion: NAMPT overexpression is a risk factor for joint injuries and nutrient depletion in RA. Supplementation with lipids would exert beneficial effects on these RA patients. Its aftermath would cause even severe inflammation. Contrarily,
    Sprache Englisch
    Erscheinungsdatum 2023-09-26
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S431600
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: SIRT1 inhibitors within Qing-Luo-Yin alleviated white adipose tissues-mediated inflammation in antigen-induced arthritis mice.

    Ye, Peng / Wang, Qi-Hai / Liu, Chun-Sheng / Li, Guo-Hao / Olatunji, Opeyemi Joshua / Lin, Jia-Ting / Zuo, Jian

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2023  Band 122, Seite(n) 155132

    Abstract: Background: White adipose tissues (WAT) release large amounts of inflammatory mediators, which are responsible for the pathology of rheumatoid arthritis (RA).: Purpose: The current study investigated the involvement of WAT in the treatments of ... ...

    Abstract Background: White adipose tissues (WAT) release large amounts of inflammatory mediators, which are responsible for the pathology of rheumatoid arthritis (RA).
    Purpose: The current study investigated the involvement of WAT in the treatments of antigen-induced arthritis (AIA) mice with the herbal formula Qing-Luo-Yin (QLY).
    Methods: Cytokines and biochemical/metabolic indicators were determined by ELISA and colorimetry methods, respectively. Monocytes were analyzed by flow cytometry. Tissues were subjected to PCR, western-blot and histological analyses. Pre-adipocytes were cultured in the different mouse serum from the in vivo experiment, and some of them were treated by certain compounds or/and lipopolysaccharide. Afterwards, the catalytic activity and thermostability of SIRT1 were tested. Gene/protein expression and cytokine production were investigated too. NAMPT and SIRT1 were silenced in some cells by siRNA.
    Results: AIA mice suffered from inflammatory adipokines-mediated metabolism and immune disorders. Besides joint protective effects, QLY therapies favored adipocyte differentiation and suppressed inflammatory adipokines release. The up-regulation of fatty acid oxidation and inflammatory monocyte polarization was therefore inhibited in peripheral tissues. PPARγ expression was generally promoted by QLY. Whereas, SIRT1 activity was always impaired, indicated by the declined NAD
    Conclusion: SIRT1 inhibitors in QLY reduced eNAMPT production and up-regulated PPARγ in AIA mice, leading to inflammation remission. These clues show that except for the well-known anti-inflammatory functions, SIRT1 participates in inflammatory reactions too and could be a potential anti-rheumatic target.
    Mesh-Begriff(e) Mice ; Animals ; Sirtuin 1/metabolism ; PPAR gamma ; Cytokines/metabolism ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Adipokines ; Inflammation/drug therapy
    Chemische Substanzen Sirtuin 1 (EC 3.5.1.-) ; PPAR gamma ; Cytokines ; Adipokines
    Sprache Englisch
    Erscheinungsdatum 2023-10-04
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.155132
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Orosomucoid proteins limit endoplasmic reticulum stress in plants

    Wang, Ling‐Yan / Li, Jian / Gong, Benqiang / Wang, Rui‐Hua / Chen, Yi‐Li / Yin, Jian / Yang, Chang / Lin, Jia‐Ting / Liu, Hao‐Zhuo / Yang, Yubing / Li, Jianfeng / Li, Chunyu / Yao, Nan

    New Phytologist. 2023 Nov., v. 240, no. 3 p.1134-1148

    2023  

    Abstract: Sphingolipids are cell membrane components and signaling molecules that induce endoplasmic reticulum (ER) stress responses, but the underlying mechanism is unknown. Orosomucoid proteins (ORMs) negatively regulate serine palmitoyltransferase activity, ... ...

    Abstract Sphingolipids are cell membrane components and signaling molecules that induce endoplasmic reticulum (ER) stress responses, but the underlying mechanism is unknown. Orosomucoid proteins (ORMs) negatively regulate serine palmitoyltransferase activity, thus helping maintain proper sphingolipid levels in humans, yeast, and plants. In this report, we explored the roles of ORMs in regulating ER stress in Arabidopsis thaliana. Loss of ORM1 and ORM2 function caused constitutive activation of the unfolded protein response (UPR), as did treatment with the ceramide synthase inhibitor Fumonisin B1 (FB1) or ceramides. FB1 treatment induced the transcription factor bZIP28 to relocate from the ER membrane to the nucleus. The transcription factor WRKY75 positively regulates the UPR and physically interacted with bZIP28. We also found that the orm mutants showed impaired ER‐associated degradation (ERAD), blocking the degradation of misfolded MILDEW RESISTANCE LOCUS‐O 12 (MLO‐12). ORM1 and ORM2 bind to EMS‐MUTAGENIZED BRI1 SUPPRESSOR 7 (EBS7), a plant‐specific component of the Arabidopsis ERAD complex, and regulate its stability. These data strongly suggest that ORMs in the ER membrane play vital roles in the UPR and ERAD pathways to prevent ER stress in Arabidopsis. Our results reveal that ORMs coordinate sphingolipid homeostasis with ER quality control and play a role in stress responses.
    Schlagwörter Arabidopsis thaliana ; cell membranes ; ceramides ; endoplasmic reticulum ; endoplasmic reticulum stress ; fumonisin B1 ; homeostasis ; mildews ; quality control ; serine C-palmitoyltransferase ; sphingosine N-acyltransferase ; transcription factors ; unfolded protein response ; yeasts
    Sprache Englisch
    Erscheinungsverlauf 2023-11
    Umfang p. 1134-1148.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19200
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Orosomucoid proteins limit endoplasmic reticulum stress in plants.

    Wang, Ling-Yan / Li, Jian / Gong, Benqiang / Wang, Rui-Hua / Chen, Yi-Li / Yin, Jian / Yang, Chang / Lin, Jia-Ting / Liu, Hao-Zhuo / Yang, Yubing / Li, Jianfeng / Li, Chunyu / Yao, Nan

    The New phytologist

    2023  Band 240, Heft 3, Seite(n) 1134–1148

    Abstract: Sphingolipids are cell membrane components and signaling molecules that induce endoplasmic reticulum (ER) stress responses, but the underlying mechanism is unknown. Orosomucoid proteins (ORMs) negatively regulate serine palmitoyltransferase activity, ... ...

    Abstract Sphingolipids are cell membrane components and signaling molecules that induce endoplasmic reticulum (ER) stress responses, but the underlying mechanism is unknown. Orosomucoid proteins (ORMs) negatively regulate serine palmitoyltransferase activity, thus helping maintain proper sphingolipid levels in humans, yeast, and plants. In this report, we explored the roles of ORMs in regulating ER stress in Arabidopsis thaliana. Loss of ORM1 and ORM2 function caused constitutive activation of the unfolded protein response (UPR), as did treatment with the ceramide synthase inhibitor Fumonisin B1 (FB1) or ceramides. FB1 treatment induced the transcription factor bZIP28 to relocate from the ER membrane to the nucleus. The transcription factor WRKY75 positively regulates the UPR and physically interacted with bZIP28. We also found that the orm mutants showed impaired ER-associated degradation (ERAD), blocking the degradation of misfolded MILDEW RESISTANCE LOCUS-O 12 (MLO-12). ORM1 and ORM2 bind to EMS-MUTAGENIZED BRI1 SUPPRESSOR 7 (EBS7), a plant-specific component of the Arabidopsis ERAD complex, and regulate its stability. These data strongly suggest that ORMs in the ER membrane play vital roles in the UPR and ERAD pathways to prevent ER stress in Arabidopsis. Our results reveal that ORMs coordinate sphingolipid homeostasis with ER quality control and play a role in stress responses.
    Mesh-Begriff(e) Humans ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Orosomucoid/metabolism ; Endoplasmic Reticulum Stress/physiology ; Unfolded Protein Response ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Sphingolipids/metabolism ; Ceramides/metabolism ; Transcription Factors/metabolism ; Saccharomyces cerevisiae/metabolism
    Chemische Substanzen Orosomucoid ; Arabidopsis Proteins ; Sphingolipids ; Ceramides ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2023-08-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19200
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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