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  1. Artikel: Knowledge, attitude, perceived barriers of hard-to-healed wound care and the association with confidence: A cross-sectional study among community nurses.

    Chuang, Shu-Ting / Lo, Shu-Fen / Liao, Pei-Lin / Lin, Pi-Yu / Tsay, Shwu-Feng

    Journal of tissue viability

    2023  Band 32, Heft 4, Seite(n) 487–492

    Sprache Englisch
    Erscheinungsdatum 2023-08-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1282604-2
    ISSN 0965-206X
    ISSN 0965-206X
    DOI 10.1016/j.jtv.2023.08.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: 9-POHSA prevents NF-kB activation and ameliorates LPS-induced inflammation in rat hepatocytes.

    Situmorang, Jiro Hasegawa / Chen, Ming-Cheng / Kuo, Wei-Wen / Lin, Shinn-Zong / Shih, Cheng-Yen / Lin, Pi-Yu / Loh, Ching-Hui / Huang, Chih-Yang

    Lipids

    2023  Band 58, Heft 5, Seite(n) 241–249

    Abstract: Liver inflammation has become increasingly prevalent in recent years, leading to the development of diseases like hepatitis, alcoholic liver disease, and fatty liver disease. One factor that has been linked to liver inflammation is increased levels of ... ...

    Abstract Liver inflammation has become increasingly prevalent in recent years, leading to the development of diseases like hepatitis, alcoholic liver disease, and fatty liver disease. One factor that has been linked to liver inflammation is increased levels of lipopolysaccharides (LPS), which can be caused by poor diets and sedentary lifestyles that contribute to liver inflammation. There is promising research on a new class of lipids called fatty acid esters of hydroxy fatty acids (FAHFAs), which have been shown to potentiate insulin release and exert an anti-inflammatory effect. Specifically, one type of FAHFA called 9-POHSA (palmitoleic acid ester of 9-hydroxy stearic acid) has been studied for its potential to attenuate inflammation-related indexes induced by LPS in hepatocytes, which play a critical role in the progression of liver inflammation. This study found that following LPS treatment, tumor necrosis factor- α, interleukin-6, and connective tissue growth factor (CTGF) were upregulated and increased cell migration, but 9-POHSA pre-treatment attenuated the upregulation of these markers and prevented cell migration induced by LPS. Using flowcytometry analysis, intracellular reactive oxygen species (ROS) was found to be responsible for CTGF upregulation. In addition, the effects of 9-POHSA were likely associated with its inhibition of the activation of the NF-kB. These results suggest that 9-POHSA has potential as a therapy for liver inflammation and fibrosis by attenuating inflammation-related indexes induced by LPS in hepatocytes. This study provides important insight into the mechanisms of liver inflammation and the potential for new treatments to address liver diseases.
    Mesh-Begriff(e) Animals ; Rats ; Lipopolysaccharides/toxicity ; NF-kappa B ; Inflammation/chemically induced ; Inflammation/drug therapy ; Cell Movement ; Fatty Acids ; Hepatocytes ; Hydroxy Acids
    Chemische Substanzen Lipopolysaccharides ; NF-kappa B ; Fatty Acids ; Hydroxy Acids
    Sprache Englisch
    Erscheinungsdatum 2023-08-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12380
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  3. Artikel ; Online: PKC-δ-dependent mitochondrial ROS attenuation is involved as 9-OAHSA combats lipoapotosis in rat hepatocytes induced by palmitic acid and in Syrian hamsters induced by high-fat high-cholesterol high-fructose diet.

    Loh, Ching-Hui / Kuo, Wei-Wen / Lin, Shinn-Zong / Shih, Cheng-Yen / Lin, Pi-Yu / Situmorang, Jiro Hasegawa / Huang, Chih-Yang

    Toxicology and applied pharmacology

    2023  Band 470, Seite(n) 116557

    Abstract: Metabolic-associated fatty liver disease (MAFLD) is a global concern, often undetected until reaching an advanced stage. Palmitic acid (PA) is a type of fatty acid that increases and leads to liver apoptosis in MAFLD. However, there is currently no ... ...

    Abstract Metabolic-associated fatty liver disease (MAFLD) is a global concern, often undetected until reaching an advanced stage. Palmitic acid (PA) is a type of fatty acid that increases and leads to liver apoptosis in MAFLD. However, there is currently no approved therapy or compound for MAFLD. Recently, branched fatty acid esters of hydroxy fatty acids (FAHFAs), a group of bioactive lipids, have emerged as promising agents to treat associated metabolic diseases. This study utilizes one type of FAHFA, oleic acid ester of 9-hydroxystearic acid (9-OAHSA), to treat PA-induced lipoapoptosis in an in vitro MAFLD model using rat hepatocytes and a high-fat high-cholesterol high-fructose (HFHCHFruc) diet in Syrian hamsters. The results indicate that 9-OAHSA rescues hepatocytes from PA-induced apoptosis and attenuates lipoapoptosis and dyslipidemia in Syrian hamsters. Additionally, 9-OAHSA decreases the generation of mitochondrial reactive oxygen species (mito-ROS) and stabilizes the mitochondrial membrane potential in hepatocytes. The study also demonstrates that the effect of 9-OAHSA on mito-ROS generation is at least partially mediated by PKC-δ signaling. These findings suggest that 9-OAHSA shows promise as a therapy for MAFLD.
    Mesh-Begriff(e) Cricetinae ; Rats ; Animals ; Palmitic Acid/toxicity ; Reactive Oxygen Species/metabolism ; Mesocricetus ; Fructose/toxicity ; Hepatocytes ; Fatty Acids/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Cholesterol/metabolism ; Diet, High-Fat/adverse effects
    Chemische Substanzen Palmitic Acid (2V16EO95H1) ; Reactive Oxygen Species ; Fructose (30237-26-4) ; Fatty Acids ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2023-05-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116557
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  4. Artikel ; Online: Corrigendum to "PKC-δ-dependent mitochondrial ROS attenuation is involved as 9-OAHSA combats lipoapotosis in rat hepatocytes induced by palmitic acid and in Syrian hamsters induced by high-fat high-cholesterol high-fructose diet" [Toxicology and Applied Pharmacology, 470, (2023), 116557].

    Loh, Ching-Hui / Kuo, Wei-Wen / Lin, Shinn-Zong / Shih, Cheng-Yen / Lin, Pi-Yu / Situmorang, Jiro Hasegawa / Huang, Chih-Yang

    Toxicology and applied pharmacology

    2023  Band 476, Seite(n) 116658

    Sprache Englisch
    Erscheinungsdatum 2023-08-19
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116658
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  5. Artikel ; Online: 9‐POHSA prevents NF‐kB activation and ameliorates LPS‐induced inflammation in rat hepatocytes

    Situmorang, Jiro Hasegawa / Chen, Ming‐Cheng / Kuo, Wei‐Wen / Lin, Shinn‐Zong / Shih, Cheng‐Yen / Lin, Pi‐Yu / Loh, Ching‐Hui / Huang, Chih‐Yang

    Lipids. 2023 Sept., v. 58, no. 5 p.241-249

    2023  

    Abstract: Liver inflammation has become increasingly prevalent in recent years, leading to the development of diseases like hepatitis, alcoholic liver disease, and fatty liver disease. One factor that has been linked to liver inflammation is increased levels of ... ...

    Abstract Liver inflammation has become increasingly prevalent in recent years, leading to the development of diseases like hepatitis, alcoholic liver disease, and fatty liver disease. One factor that has been linked to liver inflammation is increased levels of lipopolysaccharides (LPS), which can be caused by poor diets and sedentary lifestyles that contribute to liver inflammation. There is promising research on a new class of lipids called fatty acid esters of hydroxy fatty acids (FAHFAs), which have been shown to potentiate insulin release and exert an anti‐inflammatory effect. Specifically, one type of FAHFA called 9‐POHSA (palmitoleic acid ester of 9‐hydroxy stearic acid) has been studied for its potential to attenuate inflammation‐related indexes induced by LPS in hepatocytes, which play a critical role in the progression of liver inflammation. This study found that following LPS treatment, tumor necrosis factor‐ α, interleukin‐6, and connective tissue growth factor (CTGF) were upregulated and increased cell migration, but 9‐POHSA pre‐treatment attenuated the upregulation of these markers and prevented cell migration induced by LPS. Using flowcytometry analysis, intracellular reactive oxygen species (ROS) was found to be responsible for CTGF upregulation. In addition, the effects of 9‐POHSA were likely associated with its inhibition of the activation of the NF‐kB. These results suggest that 9‐POHSA has potential as a therapy for liver inflammation and fibrosis by attenuating inflammation‐related indexes induced by LPS in hepatocytes. This study provides important insight into the mechanisms of liver inflammation and the potential for new treatments to address liver diseases.
    Schlagwörter anti-inflammatory activity ; cell movement ; fatty liver ; fibrosis ; hepatitis ; hepatocytes ; inflammation ; insulin ; interleukin-6 ; lipopolysaccharides ; liver ; necrosis ; neoplasms ; palmitoleic acid ; rats ; reactive oxygen species ; stearic acid ; therapeutics ; transcription factor NF-kappa B
    Sprache Englisch
    Erscheinungsverlauf 2023-09
    Umfang p. 241-249.
    Erscheinungsort John Wiley & Sons, Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12380
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Köln/Königswinter

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  6. Artikel ; Online: A prospective review of the health-promoting potential of Jing Si Herbal Tea.

    Ho, Tsung-Jung / Ahmed, Tanvir / Shibu, Marthandam Asokan / Lin, Yu-Jung / Shih, Cheng Yen / Lin, Pi-Yu / Ling, Shinn-Zong / Chiang, Chien-Yi / Kuo, Wei-Wen / Huang, Chih-Yang

    Tzu chi medical journal

    2024  Band 36, Heft 1, Seite(n) 1–22

    Abstract: Traditional Chinese medicine (TCM) has gained considerable attention over the past few years for its multicomponent, multitarget, and multi-pathway approach to treating different diseases. Studies have shown that TCMs as adjuvant therapy along with ... ...

    Abstract Traditional Chinese medicine (TCM) has gained considerable attention over the past few years for its multicomponent, multitarget, and multi-pathway approach to treating different diseases. Studies have shown that TCMs as adjuvant therapy along with conventional treatment may benefit in safely treating various disorders. However, investigations on finding effective herbal combinations are ongoing. A novel TCM formula, "Jing Si Herbal Tea (JSHT)," has been reported recently for their health-promoting effects in improving overall body and mental health. JSHT is a combination of eight herbs recognized in Chinese herbal pharmacopoeia for their anti-viral, anti-aging, and anti-cancer properties as well as protective effects against cardiovascular, metabolic, neural, digestive, and genitourinary diseases. Thus, to better understand the beneficial effects of the ingredients of JSHT on health, this review intends to summarize the preclinical and clinical studies of the ingredients of JSHT on human health and diseases, and possible therapeutic effects with the related mode of actions and future prospects for their application in complementary therapies.
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland India
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2452925-4
    ISSN 2223-8956 ; 2223-8956
    ISSN (online) 2223-8956
    ISSN 2223-8956
    DOI 10.4103/tcmj.tcmj_194_23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Ohwia caudata

    Ho, Tsung-Jung / Tsai, Bruce Chi-Kang / Debakshee, Goswami / Shibu, Marthandam Asokan / Kuo, Chia-Hua / Lin, Chih-Hsueh / Lin, Pi-Yu / Lin, Shinn-Zong / Kuo, Wei-Wen / Huang, Chih-Yang

    Heliyon

    2024  Band 10, Heft 9, Seite(n) e29729

    Abstract: Stem cells exhibit pluripotency and self-renewal abilities. Adipose-derived mesenchymal stem cells can potentially be used to reconstruct various tissues. They possess significant versatility and alleviate various aging-related diseases. Unfortunately, ... ...

    Abstract Stem cells exhibit pluripotency and self-renewal abilities. Adipose-derived mesenchymal stem cells can potentially be used to reconstruct various tissues. They possess significant versatility and alleviate various aging-related diseases. Unfortunately, aging leads to senescence, apoptosis, and a decline in regenerative capacity in adipose-derived mesenchymal stem cells. These changes necessitate a strategy to mitigate the effects of aging on stem cells.
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29729
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Ohwia caudata extract relieves the IL‐17A‐induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation

    Lu, Cheng‐You / Kuo, Chia‐Hua / Kuo, Wei‐Wen / Hsieh, Dennis Jine‐Yuan / Wang, Tso‐Fu / Shih, Cheng‐Yen / Lin, Pi‐Yu / Lin, Shinn‐Zong / Ho, Tsung‐Jung / Huang, Chih‐Yang

    Environmental Toxicology. 2023 Aug., v. 38, no. 8 p.1914-1924

    2023  

    Abstract: Fibroblast‐like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer ... ...

    Abstract Fibroblast‐like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling triggers inflammation, and induces cytokine levels in RA. Ohwia caudata have long been used against many disorders. However, in RA, the effects of O. caudata have not been elucidated. In the current study, synoviocytes were used to evaluate the suppressive effects of O. caudate extract (OCE) on the pro‐inflammatory cytokines production. In vitro, the underlying mechanisms by which OCE inhibits inflammatory response through regulation of suppressors of cytokine signaling 3 (SOCS3) and JAK2/STAT3 expression in IL‐17A‐treated HIG‐82 synoviocytes were investigated. The results demonstrated that the proliferation of IL‐17A‐challenged cells were increased in comparison with non‐stimulated control cells. The synoviocyte proliferation was decreased significantly of OCE concentrations in dose dependent manner. The p‐JAK2, p‐STAT3, interleukin (IL)‐1β, and IL‐6 were reduced in IL‐17A‐challenged cells treated with OCE. Furthermore, AZD1480 (a JAK2‐specific inhibitor) or WP1066 (a STAT3‐specific inhibitor) affected the inflammatory mediators production in IL‐17A‐challenged synoviocytes, and OCE failed to mitigate the IL‐17A‐induced inflammatory mediators and SOCS3, acting as a feedback inhibitor of the JAK/STAT3 pathway, in the presence of SOCS3 siRNA, indicating that the beneficial effects of OCE on the regulation of inflammatory response homeostasis were dependent on SOCS3 and the JAK2/STAT3 signaling pathway. Our study also showed that SOCS3 was markedly activated by OCE in RA fibroblast‐like synoviocytes, thereby decreasing the JAK/STAT3 pathway, and the IL‐1β, and IL‐6 activation. Thus, O. caudate should be further investigated as a candidate anti‐inflammatory and anti‐arthritic agent.
    Schlagwörter dose response ; ecotoxicology ; homeostasis ; inflammation ; interleukin-6 ; non-specific protein-tyrosine kinase ; rheumatoid arthritis ; transactivators
    Sprache Englisch
    Erscheinungsverlauf 2023-08
    Umfang p. 1914-1924.
    Erscheinungsort John Wiley & Sons, Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23818
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  9. Artikel ; Online: Ohwia caudata aqueous extract attenuates doxorubicin‐induced mitochondrial dysfunction in Wharton's jelly‐derived mesenchymal stem cells

    Lee, Pei‐Ying / Tsai, Bruce Chi‐Kang / Sitorus, Maria Angelina / Lin, Pi‐Yu / Lin, Shinn‐Zong / Shih, Cheng‐Yen / Lu, Shang‐Yeh / Lin, Yueh‐Min / Ho, Tsung‐Jung / Huang, Chih‐Yang

    Environmental Toxicology. 2023 Oct., v. 38, no. 10 p.2450-2461

    2023  

    Abstract: Mitochondrial dysfunction has been linked to many diseases, including organ degeneration and cancer. Wharton's jelly‐derived mesenchymal stem cells provide a valuable source for stem cell‐based therapy and represent an emerging therapeutic approach for ... ...

    Abstract Mitochondrial dysfunction has been linked to many diseases, including organ degeneration and cancer. Wharton's jelly‐derived mesenchymal stem cells provide a valuable source for stem cell‐based therapy and represent an emerging therapeutic approach for tissue regeneration. This study focused on screening the senomorphic properties of Ohwia caudata aqueous extract as an emerging strategy for preventing or treating mitochondrial dysfunction in stem cells. Wharton's jelly‐derived mesenchymal stem cells were incubated with 0.1 μM doxorubicin, for 24 h to induce mitochondrial dysfunction. Next, the cells were treated with a series concentration of Ohwia caudata aqueous extract (25, 50, 100, and 200 μg/mL) for another 24 h. In addition, an untreated control group and a doxorubicin‐induced mitochondrial dysfunction positive control group were maintained under the same conditions. Our data showed that Ohwia caudata aqueous extract markedly suppressed doxorubicin‐induced mitochondrial dysfunction by increasing Tid1 and Tom20 expression, decreased reactive oxygen species production, and maintained mitochondrial membrane potential to promote mitochondrial stability. Ohwia caudata aqueous extract retained the stemness of Wharton's jelly‐derived mesenchymal stem cells and reduced the apoptotic rate. These results indicate that Ohwia caudata aqueous extract protects Wharton's jelly‐derived mesenchymal stem cells against doxorubicin‐induced mitochondrial dysfunction and can potentially prevent mitochondrial dysfunction in other cells. This study provides new directions for the medical application of Ohwia caudata.
    Schlagwörter apoptosis ; doxorubicin ; ecotoxicology ; membrane potential ; mitochondria ; mitochondrial membrane ; reactive oxygen species ; therapeutics ; tissue repair
    Sprache Englisch
    Erscheinungsverlauf 2023-10
    Umfang p. 2450-2461.
    Erscheinungsort John Wiley & Sons, Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23880
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel: Protective effects of

    Lin, Heng-Dao / Lee, Yuan-Chieh / Chiang, Chien-Yi / Lin, Yu-Jung / Shih, Cheng Yen / Tsai, Rong-Kung / Lin, Pi-Yu / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang

    Frontiers in nutrition

    2023  Band 10, Seite(n) 1085248

    Abstract: Diabetic retinopathy (DR) is a major cause of vision loss in diabetic patients. Hyperglycemia-induced oxidative stress and the accumulation of inflammatory factors result in blood-retinal barrier dysfunction and the pathogenesis of DR. ...

    Abstract Diabetic retinopathy (DR) is a major cause of vision loss in diabetic patients. Hyperglycemia-induced oxidative stress and the accumulation of inflammatory factors result in blood-retinal barrier dysfunction and the pathogenesis of DR.
    Sprache Englisch
    Erscheinungsdatum 2023-03-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1085248
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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