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  1. Buch ; Dissertation / Habilitation: Interaction of TGF-beta-1 and radiation in fibroblasts as a model of wound healing in combination with postoperative and intraoperative radiotherapy

    Ma, Lin

    2013  

    Verfasserangabe vorgelegt von Lin Ma
    Sprache Englisch
    Umfang 103 S. : Ill., graph. Darst.
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Heidelberg, Univ., Diss., 2014
    HBZ-ID HT018464382
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2014 E 1549 bestellbar zur Ausleihe Magazin

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  2. Artikel ; Online: Safety and anatomical outcome analysis after flow diverter coverage of the anterior cerebral artery.

    Lin Ma, Wu / Deng, Xin / Si An, Meng / Liu, Shuo / Bin Guo, Xin

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2024  Band 124, Seite(n) 73–77

    Abstract: Objectives: Few studies on ischemic complications and flow changes after a flow diverter covering the anterior cerebral artery. The purpose of the study was to explore the ischemic complications and anatomical alterations associated with the flow ... ...

    Abstract Objectives: Few studies on ischemic complications and flow changes after a flow diverter covering the anterior cerebral artery. The purpose of the study was to explore the ischemic complications and anatomical alterations associated with the flow diverter after it covers the anterior cerebral artery.
    Materials and methods: In this single-center study, patients treated with FD covering the anterior cerebral artery at the First Affiliated Hospital of Zhengzhou University were retrospectively collected. The primary endpoint was ischemic complications related to the anterior cerebral artery. Secondary endpoints were anatomical changes in the anterior cerebral artery postoperatively and at follow-up.
    Results: A total of 59 patients were included in this study. Four (6.8%) patients presented with ischemic stroke symptoms. Immediately after the procedure, complete occlusion of A1 and decreased blood flow was observed in 13 (22.0%) and 21 patients (35.6%), respectively. At follow-up, A1 artery was occluded in 34 patients (57.6%) and decreased blood flow was observed in 10 patients (16.9%). Symptoms of neurological deficits related to the anterior cerebral artery were not observed in all patients at follow-up.
    Conclusion: Coverage of A1 is safe, with a low incidence of ischemic stroke, when using an FD to treat aneurysms. Risk of reduced perfusion of the anterior cerebral artery postoperatively even if the anterior communicating artery is open. In cases with A1 occlusion, the blood flow in the distal the anterior cerebral artery can be adequately compensated by opening the anterior communicating artery and good vascular anastomoses.
    Mesh-Begriff(e) Humans ; Male ; Female ; Anterior Cerebral Artery/surgery ; Anterior Cerebral Artery/diagnostic imaging ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Intracranial Aneurysm/surgery ; Treatment Outcome ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Follow-Up Studies ; Cerebrovascular Circulation/physiology
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2024.03.027
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3999: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel ; Online: Manifest Quasi-Universals and Embedding Conceptual Clusters

    Jaap van Brakel / Lin Ma

    Asian Studies, Vol 10, Iss

    2022  Band 3

    Abstract: We start this article with a discussion of the problematics involved in translating into modern English a (modern) Chinese text concerning a classical Chinese notion, namely qíng 情. Then, we suggest that it is necessary to distinguish between two levels ... ...

    Abstract We start this article with a discussion of the problematics involved in translating into modern English a (modern) Chinese text concerning a classical Chinese notion, namely qíng 情. Then, we suggest that it is necessary to distinguish between two levels on which a language is used. The first is the manifest level, where one finds family resemblance between, say, Chinese nù 怒 and English “anger”. The second is the generic level, where one finds qíng in classical Chinese, qínggaˇn in modern Chinese, and emotion(s) in English. We argue that the meanings of words at the generic level can only be accessed via the manifest level. It is misleading to directly identify and compare notions at the generic level (in this case, emotion(s) in English and qíng in Chinese). We call the connections at the manifest level “quasi-universals”, and we refer to the notions at the generic level as “embedding conceptual clusters”.
    Schlagwörter translation ; Chinese ; qíng ; quasi-universals ; embedding conceptual clusters ; Social sciences and state - Asia (Asian studies only) ; H53
    Thema/Rubrik (Code) 410
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag University of Ljubljana Press (Založba Univerze v Ljubljani)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Clinical effectiveness of supraspinatus tendon reconstruction using autogenous fascia latas for irreparable posterosuperior massive rotator cuff tears

    Lin Ma / Xiaoli Gou / Binghua Zhou

    Trials, Vol 24, Iss 1, Pp 1-

    study protocol for a randomized, controlled clinical trial

    2023  Band 10

    Abstract: Abstract Background Supraspinatus tendon reconstruction (STR) was recently introduced as a new treatment option for irreparable posterosuperior massive rotator cuff tears (IPMRCT). STR was thought to be more advantageous than superior capsule ... ...

    Abstract Abstract Background Supraspinatus tendon reconstruction (STR) was recently introduced as a new treatment option for irreparable posterosuperior massive rotator cuff tears (IPMRCT). STR was thought to be more advantageous than superior capsule reconstruction (SCR) for restoring supraspinatus (SSP) dynamics. However, there has been no prospective randomized controlled study on the early clinical efficacy of STR. Methods A single-site, prospective, observers and patients double-blinding randomized controlled trial was designed. Fifty-eight patients aged 50–85 years with IPMRCT will be randomized 1:1 to receive either STR or SCR. The clinical outcomes were evaluated using the American Society for Shoulder and Elbow Surgery (ASES) score, range of motion (ROM), visual analogue scale (VAS) for pain, acromiohumeral distance (AHD), Goutlliar grade for fatty infiltration in the SSP, Sugaya grade for the autogenous fascia latas, isokinetic muscle strength testing and surface electromyography (EMG) testing for shoulder abduction muscle strength and complications. Discussion The results of this study will contribute to the treatment algorithm of IPMRCT and assist surgeons in making treatment decisions. This is the first randomized controlled trial to compare the effects of STR and SCR for the treatment of IPMRCT. Trial registration We registered the trial in chictr.org.cn on July 17, 2023 (register number: ChiCTR2300073716). Items from the WHO trial registry were found within the protocol.
    Schlagwörter Rotator cuff injuries ; Reconstruction ; Fascia latas ; Massive rotator cuff tears ; Randomized ; Controlled clinic trial ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Concentration or distraction? A synergetic-based attention weights optimization method

    Zihao Wang / Haifeng Li / Lin Ma / Feng Jiang

    Complex & Intelligent Systems, Vol 9, Iss 6, Pp 7381-

    2023  Band 7393

    Abstract: Abstract The attention mechanism empowers deep learning to a broader range of applications, but the contribution of the attention module is highly controversial. Research on modern Hopfield networks indicates that the attention mechanism can also be used ...

    Abstract Abstract The attention mechanism empowers deep learning to a broader range of applications, but the contribution of the attention module is highly controversial. Research on modern Hopfield networks indicates that the attention mechanism can also be used in shallow networks. Its automatic sample filtering facilitates instance extraction in Multiple Instances Learning tasks. Since the attention mechanism has a clear contribution and intuitive performance in shallow networks, this paper further investigates its optimization method based on the recurrent neural network. Through comprehensive comparison, we find that the Synergetic Neural Network has the advantage of more accurate and controllable convergences and revertible converging steps. Therefore, we design the Syn layer based on the Synergetic Neural Network and propose the novel invertible activation function as the forward and backward update formula for attention weights concentration or distraction. Experimental results show that our method outperforms other methods in all Multiple Instances Learning benchmark datasets. Concentration improves the robustness of the results, while distraction expands the instance observing space and yields better results. Codes available at https://github.com/wzh134/Syn .
    Schlagwörter Attention ; Synergetic neural network ; Recurrent neural network ; Multiple instance learning ; Shallow network ; Electronic computers. Computer science ; QA75.5-76.95 ; Information technology ; T58.5-58.64
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Springer
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Modern synergetic neural network for imbalanced small data classification

    Zihao Wang / Haifeng Li / Lin Ma

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 10

    Abstract: Abstract Deep learning’s performance on the imbalanced small data is substantially degraded by overfitting. Recurrent neural networks retain better performance in such tasks by constructing dynamical systems for robustness. Synergetic neural network (SNN) ...

    Abstract Abstract Deep learning’s performance on the imbalanced small data is substantially degraded by overfitting. Recurrent neural networks retain better performance in such tasks by constructing dynamical systems for robustness. Synergetic neural network (SNN), a synergetic-based recurrent neural network, has superiorities in eliminating recall errors and pseudo memories, but is subject to frequent association errors. Since the cause remains unclear, most subsequent studies use genetic algorithms to adjust parameters for better accuracy, which occupies the parameter optimization space and hinders task-oriented tuning. To solve the problem and promote SNN’s application capability, we propose the modern synergetic neural network (MSNN) model. MSNN solves the association error by correcting the state initialization method in the working process, liberating the parameter optimization space. In addition, MSNN optimizes the attention parameter of the network with the error backpropagation algorithm and the gradient bypass technique to allow the network to be trained jointly with other network layers. The self-learning of the attention parameter empowers the adaptation to the imbalanced sample size, further improving the classification performance. In 75 classification tasks of small UC Irvine Machine Learning Datasets, the average rank of the MSNN achieves the best result compared to 187 neural and non-neural network machine learning methods.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Dermoscopic Patterns in Juvenile Xanthogranuloma Based on the Histological Classification

    Jiaosheng Xu / Lin Ma

    Frontiers in Medicine, Vol

    2021  Band 7

    Abstract: Background: Several dermoscopic features of juvenile xanthogranuloma (JXG) have been previously described in single cases or small case series and need to be further verified in a large sample.Objective: We aimed to investigate the dermoscopic patterns ... ...

    Abstract Background: Several dermoscopic features of juvenile xanthogranuloma (JXG) have been previously described in single cases or small case series and need to be further verified in a large sample.Objective: We aimed to investigate the dermoscopic patterns of JXG in a large case series and the correlations of these with clinical features of different histopathological subtypes of JXG.Methods: Patients who underwent dermoscopic evaluation and had a histopathological diagnosis of JXG were recruited. Histological findings, including stage and Ki67 proliferative index and the dermoscopic features of each lesion were recorded.Results: Forty-one patients with JXG were included. The male to female ratio was 1.28: 1 and the median age of onset was 11 months (range: 0–95 months). Fourteen lesions were histologically categorized in the early stage, 17 in the developed stage, and 10 in the late stage. The “setting sun” pattern was observed in 35 lesions (85.4%) and “clouds” of paler yellow areas in 26 lesions (63.4%). The frequency of the “setting sun” pattern was higher in the early and developed stages (30/31) than in the late stage (5/10) (P = 0.002), while that of “clouds” of paler yellow areas was not significantly different between each stage. Branched linear vessels were detected in the early (11/14) and developed stage (6/17), but not in the late stage. The mean Ki67 index of the lesions with linear vessels was 11.8% (range: 2–40%), which was higher than that of lesions without linear vessels (mean index: 5%, range: 1–30%) (P = 0.005). The pigment network and whitish areas were only detected in 6 and 5 lesions in the late stage, respectively. The whitish areas presented either as streak or stellate shape. The pigment network exhibited either in a centric or a peripheral pattern.Conclusions: The “setting sun” pattern is the characteristic dermoscopic features of JXG in the early and developed stages, while whitish areas and pigment network are the characteristic patterns in the late stage. Linear vessels present as ...
    Schlagwörter juvenile xanthogranuloma ; dermoscopy ; clinics ; histology ; follow-up ; diagnosis ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: Co-Immobilization of Lipases with Different Specificities for Efficient and Recyclable Biodiesel Production from Waste Oils

    Qian Wang / Rongjing Zhang / Maogen Liu / Lin Ma / Weiwei Zhang

    International Journal of Molecular Sciences, Vol 24, Iss 4726, p

    Optimization Using Response Surface Methodology

    2023  Band 4726

    Abstract: Lipase-catalyzed transesterification is a promising and sustainable approach to producing biodiesel. To achieve highly efficient conversion of heterogeneous oils, combining the specificities and advantages of different lipases is an attractive strategy. ... ...

    Abstract Lipase-catalyzed transesterification is a promising and sustainable approach to producing biodiesel. To achieve highly efficient conversion of heterogeneous oils, combining the specificities and advantages of different lipases is an attractive strategy. To this end, highly active Thermomyces lanuginosus lipase (1,3-specific) and stable Burkholderia cepacia lipase (non-specific) were covalently co-immobilized on 3-glycidyloxypropyltrimethoxysilane (3-GPTMS) modified Fe 3 O 4 magnetic nanoparticles (co-BCL-TLL@Fe 3 O 4 ). The co-immobilization process was optimized using response surface methodology (RSM). The obtained co-BCL-TLL@Fe 3 O 4 exhibited a significant improvement in activity and reaction rate compared with mono and combined-use lipases, achieving 92.9% yield after 6 h under optimal conditions, while individually immobilized TLL, immobilized BCL and their combinations exhibited yields of 63.3%, 74.2% and 70.6%, respectively. Notably, co-BCL-TLL@Fe 3 O 4 achieved 90–98% biodiesel yields after 12 h using six different feedstocks, demonstrating the perfect synergistic effect of BCL and TLL remarkably motivated in co-immobilization. Furthermore, co-BCL-TLL@Fe 3 O 4 could maintain 77% of initial activity after nine cycles by removing methanol and glycerol from catalyst surface, accomplished by washing with t -butanol. The high catalytic efficiency, wide substrate adaptability and favorable reusability of co-BCL-TLL@Fe 3 O 4 suggest that it will be an economical and effective biocatalyst for further applications.
    Schlagwörter biodiesel ; lipase ; co-immobilization ; process optimization ; waste oils ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 290
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: The Influence of the Size of BN NSs on Silkworm Development and Tissue Microstructure

    Vivian Andoh / Haiyan Liu / Liang Chen / Lin Ma / Keping Chen

    Nanomaterials, Vol 13, Iss 1502, p

    2023  Band 1502

    Abstract: Boron nitride nanosheets (BN NSs) have emerged as promising materials in a wide range of biomedical applications. Despite the extensive studies on these bio-nano interfacial systems, one critical concern is their toxicity, which is affected by a variety ... ...

    Abstract Boron nitride nanosheets (BN NSs) have emerged as promising materials in a wide range of biomedical applications. Despite the extensive studies on these bio-nano interfacial systems, one critical concern is their toxicity, which is affected by a variety of factors, including size. This study aimed at assessing the relationship between BN NSs size and toxicity. Two silkworm strains (qiufeng × baiyu and Nistari 7019) were used as model organisms to investigate the effect of different sizes of BN NSs (BN NSs-1, thickness of 41.5 nm and diameter of 270.7 nm; BN NSs-2, thickness of 48.2 nm and diameter of 562.2 nm) on silkworm mortality, growth, cocoon weight, and tissue microstructure. The findings show that exposure to BN NSs in this work has no lethal adverse effects on silkworm growth or tissue microstructure. BN NSs have a higher effect on the growth rate of qiufeng × baiyu compared to Nistari 7019, demonstrating that the same treatment does not favorably affect the Nistari 7019 strain, as there is no significant increase in cocoon weight. Overall, the study suggests that the sizes of BN NSs employed in this study are relatively safe and have less negative impact on silkworms. This offers significant insights into the effect of BN NSs size, a crucial factor to consider for their safe use in biomedical applications.
    Schlagwörter boron nitride nanosheets ; size effect ; silkworm development ; tissue microstructure ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag MDPI AG
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019

    Baoyi Huang / Zhaojun Wang / Yanxiang Kong / Mengqi Jin / Lin Ma

    BMC Public Health, Vol 23, Iss 1, Pp 1-

    an analysis of global burden of disease study

    2023  Band 12

    Abstract: Abstract Background Many countries and regions have experienced male fertility problems due to various influencing factors, especially in less developed countries. Unlike female infertility, male infertility receives insufficient attention. Understanding ...

    Abstract Abstract Background Many countries and regions have experienced male fertility problems due to various influencing factors, especially in less developed countries. Unlike female infertility, male infertility receives insufficient attention. Understanding the changing patterns of male infertility in the world, different regions and different countries is crucial for assessing the global male fertility and reproductive health. Methods We obtained data on prevalence, years of life lived with disability (YLD), age-standardized rates of prevalence (ASPR) and age-standardized YLD rate (ASYR) from the Global Burden of Disease Study 2019. We analyzed the burden of male infertility at all levels, including global, regional, national, age stratification and Socio-demographic Index (SDI). Results In 2019, the global prevalence of male infertility was estimated to be 56,530.4 thousand (95% UI: 31,861.5–90,211.7), reflecting a substantial 76.9% increase since 1990. Furthermore, the global ASPR stood at 1,402.98 (95% UI: 792.24–2,242.45) per 100,000 population in 2019, representing a 19% increase compared to 1990. The regions with the highest ASPR and ASYR for male infertility in 2019 were Western Sub-Saharan Africa, Eastern Europe, and East Asia. Notably, the prevalence and YLD related to male infertility peaked in the 30–34 year age group worldwide. Additionally, the burden of male infertility in the High-middle SDI and Middle SDI regions exceeded the global average in terms of both ASPR and ASYR. Conclusion The global burden of male infertility has exhibited a steady increase from 1990 to 2019, as evidenced by the rising trends in ASPR and ASYR, particularly in the High-middle and Middle SDI regions. Notably, the burden of male infertility in these regions far exceeds the global average. Additionally, since 2010, there has been a notable upward trend in the burden of male infertility in Low and Middle-low SDI regions. Given these findings, it is imperative to prioritize efforts aimed at improving male fertility and ...
    Schlagwörter Male infertility ; Global burden of disease ; Years lived with disability ; Socio-demographic index ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 306
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
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