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  1. Artikel ; Online: Erratum to: Ability of vaccine strain induced antibodies to neutralize field isolates of caliciviruses from Swedish cats.

    Wensman, Jonas Johansson / Samman, Ayman / Lindhe, Anna / Thibault, Jean-Christophe / Berndtsson, Louise Treiberg / Hosie, Margaret J

    Acta veterinaria Scandinavica

    2016  Band 58, Seite(n) 14

    Sprache Englisch
    Erscheinungsdatum 2016-02-17
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 40137-7
    ISSN 1751-0147 ; 0044-605X
    ISSN (online) 1751-0147
    ISSN 0044-605X
    DOI 10.1186/s13028-016-0194-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Ability of vaccine strain induced antibodies to neutralize field isolates of caliciviruses from Swedish cats.

    Wensman, Jonas Johansson / Samman, Ayman / Lindhe, Anna / Thibault, Jean-Christophe / Berndtsson, Louise Treiberg / Hosie, Margaret J

    Acta veterinaria Scandinavica

    2015  Band 57, Seite(n) 86

    Abstract: Background: Feline calicivirus (FCV) is a common cause of upper respiratory tract disease in cats worldwide. Its characteristically high mutation rate leads to escape from the humoral immune response induced by natural infection and/or vaccination and ... ...

    Abstract Background: Feline calicivirus (FCV) is a common cause of upper respiratory tract disease in cats worldwide. Its characteristically high mutation rate leads to escape from the humoral immune response induced by natural infection and/or vaccination and consequently vaccines are not always effective against field isolates. Thus, there is a need to continuously investigate the ability of FCV vaccine strain-induced antibodies to neutralize field isolates.
    Methods: Seventy-eight field isolates of FCV isolated during the years 2008-2012 from Swedish cats displaying clinical signs of upper respiratory tract disease were examined in this study. The field isolates were tested for cross-neutralization using a panel of eight anti-sera raised in four pairs of cats following infection with four vaccine strains (F9, 255, G1 and 431).
    Results: The anti-sera raised against F9 and 255 neutralised 20.5 and 11.5 %, and 47.4 and 64.1 % of field isolates tested, respectively. The anti-sera against the more recently introduced vaccine strains G1 and 431 neutralized 33.3 and 55.1 % (strain G1) or 69.2 and 89.7 % (strain 431) of the field isolates with titres ≥5. [corrected]. Dual vaccine strains displayed a higher cross-neutralization.
    Conclusions: This study confirms previous observations that more recently introduced vaccine strains induce antibodies with a higher neutralizing capacity compared to vaccine strains that have been used extensively over a long period of time. This study also suggests that dual FCV vaccine strains might neutralize more field isolates compared to single vaccine strains. Vaccine strains should ideally be selected based on updated knowledge on the antigenic properties of field isolates in the local setting, and there is thus a need for continuously studying the evolution of FCV together with the neutralizing capacity of vaccine strain induced antibodies against field isolates at a national and/or regional level.
    Mesh-Begriff(e) Animals ; Antibodies, Viral/immunology ; Caliciviridae Infections/immunology ; Caliciviridae Infections/veterinary ; Caliciviridae Infections/virology ; Calicivirus, Feline/immunology ; Cat Diseases/immunology ; Cat Diseases/virology ; Cats ; Neutralization Tests/veterinary ; Sweden ; Viral Vaccines/immunology
    Chemische Substanzen Antibodies, Viral ; Viral Vaccines
    Sprache Englisch
    Erscheinungsdatum 2015-12-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 40137-7
    ISSN 1751-0147 ; 0044-605X
    ISSN (online) 1751-0147
    ISSN 0044-605X
    DOI 10.1186/s13028-015-0178-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Evaluation of cytologic findings in feline conjunctivitis.

    Hillström, Anna / Tvedten, Harold / Källberg, Maria / Hanås, Sofia / Lindhe, Anna / Holst, Bodil Ström

    Veterinary clinical pathology

    2012  Band 41, Heft 2, Seite(n) 283–290

    Abstract: Background: Cytologic examination of smears prepared from ocular swabs of conjunctiva from cats with conjunctivitis permits identification of the type of inflammation and possibly specific microorganisms. Results of studies of the diagnostic utility of ... ...

    Abstract Background: Cytologic examination of smears prepared from ocular swabs of conjunctiva from cats with conjunctivitis permits identification of the type of inflammation and possibly specific microorganisms. Results of studies of the diagnostic utility of cytology for detection of infectious causes of feline conjunctivitis have been inconsistent.
    Objectives: The objectives of this study were to describe cytologic findings in cats with conjunctivitis and to compare those findings with results of PCR analysis for feline herpesvirus (FHV-1), Chlamydophila felis (C felis), and Mycoplasma felis (M felis).
    Methods: Conjunctival smears from 88 cats with conjunctivitis and 10 healthy control cats were stained with a Romanowsky stain and evaluated for the type of inflammation and evidence of an infectious agent. PCR analysis for FHV-1, C felis, and M felis was performed.
    Results: Infectious agents identified by PCR analysis were FHV-1 in 9 cats (10%), C felis in 8 cats (9%), and M felis in 6 cats (7%). Inclusions interpreted as chlamydial inclusions were found in all cytologic smears from cats positive for C felis by PCR analysis and in 3 PCR-negative cats. Inclusions interpreted as Mycoplasma organisms were found in 3 of 6 cats that were PCR-positive for M felis and in 1 PCR-negative cat. FHV-1 inclusion bodies were not detected on cytologic examination.
    Conclusions: Cytologic examination can be diagnostic for C felis infection when many typical inclusions are present. Cytologic examination was unreliable in diagnosing M felis infection, and viral inclusions of FHV-1 were not found in specimens stained with Romanowsky stains.
    Mesh-Begriff(e) Animals ; Cat Diseases/diagnosis ; Cat Diseases/pathology ; Cats ; Chlamydophila/classification ; Chlamydophila Infections/diagnosis ; Chlamydophila Infections/pathology ; Chlamydophila Infections/veterinary ; Conjunctivitis/pathology ; Conjunctivitis/veterinary ; Female ; Herpesviridae Infections/diagnosis ; Herpesviridae Infections/pathology ; Herpesviridae Infections/veterinary ; Male ; Mycoplasma/classification ; Mycoplasma Infections/diagnosis ; Mycoplasma Infections/pathology ; Mycoplasma Infections/veterinary ; Real-Time Polymerase Chain Reaction
    Sprache Englisch
    Erscheinungsdatum 2012-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2114702-4
    ISSN 1939-165X ; 0275-6382
    ISSN (online) 1939-165X
    ISSN 0275-6382
    DOI 10.1111/j.1939-165X.2012.00423.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The Early Awareness and Alert System in Sweden: History and Current Status.

    Eriksson, Irene / Wettermark, Björn / Persson, Marie / Edström, Morgan / Godman, Brian / Lindhé, Anna / Malmström, Rickard E / Ramström, Helena / von Euler, Mia / Bergkvist Christensen, Anna

    Frontiers in pharmacology

    2017  Band 8, Seite(n) 674

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2017-10-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2017.00674
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Comparisons between comorbid conditions and health care consumption in rheumatoid arthritis patients with or without biological disease-modifying anti-rheumatic drugs: a register-based study.

    Bengtsson, Karin / Jacobsson, Lennart T H / Rydberg, Barbro / Kvist, Göran / Torstenson, Tomas / Dehlin, Mats / Hilme, Elisabet / Lindhé, Anna / Wallerstedt, Susanna Maria / Forsblad-d'Elia, Helena

    BMC musculoskeletal disorders

    2016  Band 17, Heft 1, Seite(n) 499

    Abstract: Background: Symptoms and prognosis of patients with rheumatoid arthritis (RA) have improved with more intensive therapy, including the biological disease-modifying anti-rheumatic drugs (bDMARDs). Real life data concerning how comorbidities are ... ...

    Abstract Background: Symptoms and prognosis of patients with rheumatoid arthritis (RA) have improved with more intensive therapy, including the biological disease-modifying anti-rheumatic drugs (bDMARDs). Real life data concerning how comorbidities are distributed among patients treated or not treated with bDMARDs are scarce. Our objective was to investigate differences in comorbidity and health care consumption in RA patients, with and without bDMARDs.
    Methods: This cross-sectional study was performed in the Southwestern part of Sweden. Patients, aged ≥ 18 years and diagnosed with RA in secondary health care during 2009-2010, were identified in the regional health care database. Aggregated data of comorbidity and health care consumption were retrieved between 2006 and 2010. RA patients treated with bDMARDs on 31st December 2010 were identified in the Swedish Rheumatology Quality Register (SRQ), which includes the biologics register Anti-Rheumatic Therapy in Sweden (ARTIS). Descriptive, comparative, univariate and multiple logistic regression analyses were used to identify factors associated with bDMARDs.
    Results: Seven thousand seven hundred and twelve (7712) RA patients were identified (age 64.8 ± 14.9 years, women 74.3%), of whom 1137 (14.7%) were treated with bDMARDs. Overall, the most common comorbidities were infections (69.2%), hypertension (41.1%), chronic respiratory disease (15.3%), ischemic heart disease (14.0%) and malignancy (13.7%). Patients without bDMARDs were older and had more comorbidity. In the multiple logistic regression analysis, older age, cerebrovascular and chronic respiratory disease, heart failure, depression and malignancy were all associated with no present bDMARDs. Infections were associated with bDMARDs. Patients treated with bDMARDs consumed more secondary outpatient care but less visits in primary health care compared to patients without bDMARDs.
    Conclusions: Patients treated with bDMARDs versus no bDMARDs were younger and had significantly lower period prevalence for most common comorbidities, with the exception of infections. Differences in comorbidities between RA patients with or without bDMARDs should be taken into consideration when evaluating effectiveness and safety of bDMARDs in ordinary care.
    Mesh-Begriff(e) Aged ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Biological Products/therapeutic use ; Chronic Disease/epidemiology ; Communicable Diseases/epidemiology ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/epidemiology ; Male ; Middle Aged ; Myocardial Ischemia/epidemiology ; Neoplasms/epidemiology ; Patient Acceptance of Health Care/statistics & numerical data ; Prevalence ; Prognosis ; Respiratory Tract Diseases/epidemiology ; Sweden/epidemiology
    Chemische Substanzen Antirheumatic Agents ; Biological Products
    Sprache Englisch
    Erscheinungsdatum 2016-12-12
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/s12891-016-1354-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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