Article ; Online: D-Xylose Blocks the Broad Negative Regulation of XylR on Lipid Metabolism and Affects Multiple Physiological Characteristics in Mycobacteria.
International journal of molecular sciences
2023 Volume 24, Issue 8
Abstract: D-xylose is the most abundant fermentable pentose, which usually represents an architectural component of the bacterial cell wall. However, its regulatory function and the involved signaling pathway in bacteria remain largely unclear. Here, we show that ... ...
Abstract | D-xylose is the most abundant fermentable pentose, which usually represents an architectural component of the bacterial cell wall. However, its regulatory function and the involved signaling pathway in bacteria remain largely unclear. Here, we show that D-xylose can act as a signaling molecule to regulate the lipid metabolism and affect multiple physiological characteristics in mycobacteria. D-xylose directly interacts with XylR and inhibits its DNA-binding ability, thus blocking XylR-mediated repression. The xylose inhibitor, XylR, plays a global regulatory role and affects the expression of 166 mycobacterial genes that are involved in lipid synthesis and metabolism. Furthermore, we show that the xylose-dependent gene regulation of XylR affects the multiple physiological characteristics of |
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MeSH term(s) | Xylose/metabolism ; Transcription Factors/metabolism ; Lipid Metabolism ; Pentoses ; Mycobacterium smegmatis/genetics ; Mycobacterium smegmatis/metabolism ; Gene Expression Regulation, Bacterial ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism |
Chemical Substances | Xylose (A1TA934AKO) ; Transcription Factors ; Pentoses ; Bacterial Proteins |
Language | English |
Publishing date | 2023-04-11 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2019364-6 |
ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
ISSN (online) | 1422-0067 |
ISSN | 1422-0067 ; 1661-6596 |
DOI | 10.3390/ijms24087086 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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