Artikel ; Online: Integrative analysis based on the cell cycle-related genes identifies TPX2 as a novel prognostic biomarker associated with tumor immunity in breast cancer.
Aging
2024 Band 16, Heft 8, Seite(n) 7188–7216
Abstract: Background: This study aims to identify the essential cell cycle-related genes associated with prognosis in breast cancer (BRCA), and to verify the relationship between the central gene and immune infiltration, so as to provide detailed and ... ...
Abstract | Background: This study aims to identify the essential cell cycle-related genes associated with prognosis in breast cancer (BRCA), and to verify the relationship between the central gene and immune infiltration, so as to provide detailed and comprehensive information for the treatment of BRCA. Materials and methods: Gene expression profiles (GSE10780, GSE21422, GSE61304) and the Cancer Genome Atlas (TCGA) BRCA data were used to identify differentially expressed genes (DEGs) and further functional enrichment analysis. STRING and Cytoscape were employed for the protein-protein interaction (PPI) network construction. TPX2 was viewed as the crucial prognostic gene by the Survival and Cox analysis. Furthermore, the connection between TPX2 expression and immune infiltrating cells and immune checkpoints in BRCA was also performed by the TIMER online database and R software. Results: A total of 18 cell cycle-related DEGs were identified in this study. Subsequently, an intersection analysis based on TCGA-BRCA prognostic genes and the above DEGs identified three genes (TPX2, UBE2C, CCNE2) as crucial prognostic candidate biomarkers. Moreover, we also demonstrated that TPX2 is closely associated with immune infiltration in BRCA and a positive relation between TPX2 and PD-L1 expression was firstly detected. Conclusions: These results revealed that TPX2 is a potential prognostic biomarker and closely correlated with immune infiltration in BRCA, which could provide powerful and efficient strategies for breast cancer immunotherapy. |
---|---|
Mesh-Begriff(e) | Humans ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/mortality ; Female ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Biomarkers, Tumor/genetics ; Prognosis ; Microtubule-Associated Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Protein Interaction Maps/genetics ; Gene Expression Profiling ; Cell Cycle/genetics ; Databases, Genetic |
Chemische Substanzen | TPX2 protein, human ; Cell Cycle Proteins ; Biomarkers, Tumor ; Microtubule-Associated Proteins |
Sprache | Englisch |
Erscheinungsdatum | 2024-04-19 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 1945-4589 |
ISSN (online) | 1945-4589 |
DOI | 10.18632/aging.205752 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.
Fernleihe an ZB MED
Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.