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Artikel ; Online: A numerically stable constrained optimal filter design method for multichannel active noise control using dual conic formulation.

Zhuang, Yongjie / Liu, Yangfan

The Journal of the Acoustical Society of America

2022 Band 152, Heft 4, Seite(n) 2169

Abstract: In practical active noise control (ANC) applications, various constraints are usually required, for example, the disturbance enhancement constraint, the robust stability constraint, and the controller output power constraint. One commonly used approach ... ...

Abstract	In practical active noise control (ANC) applications, various constraints are usually required, for example, the disturbance enhancement constraint, the robust stability constraint, and the controller output power constraint. One commonly used approach for designing a constrained ANC filter is to formulate a constrained optimization problem using an
Sprache	Englisch
Erscheinungsdatum	2022-11-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0014627
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Fractionated irradiation induces radioresistant oral carcinoma cells with enhanced malignant phenotypes.

Liu, Yangfan / Sun, Tongxu / Yang, Jin / Luo, Jingjing / Zhou, Hongmei

Archives of oral biology

2024 Band 164, Seite(n) 105988

Abstract: Objective: The fact that certain oral carcinoma patients experience radiotherapy failure implies that a more radioresistant and aggressive phenotype of surviving cancer cells potentially occurs during treatment. Our study aimed to establish ... ...

Abstract	Objective: The fact that certain oral carcinoma patients experience radiotherapy failure implies that a more radioresistant and aggressive phenotype of surviving cancer cells potentially occurs during treatment. Our study aimed to establish radioresistant oral cancer cells through a fractionated irradiation protocol that mimics clinically relevant radiotherapy dosing strategies and to investigate all-round alterations in the malignant phenotype. Methods: Radioresistant oral carcinoma cells were generated by exposing Cal27 and Detroit 562 cells to 60 Gy radiation in 10 dose-escalating fractions and verified by cell immunofluorescence. Specific markers related to the epithelial-mesenchymal transition (EMT) process and the cancer stem cell (CSC) phenotype were assessed by Western blotting. Cell invasion and migration were evaluated using Matrigel-coated transwell and wound healing assays, respectively. Nontargeted metabolomics was used to mechanistically delineate the potential metabolic patterns linked to EMT and CSCs; the CSC phenotype was also examined by sphere formation assays and cell immunofluorescence. Results: Radioresistant oral carcinoma cell lines were successfully established and validated. These cells exhibited enhanced EMT and increase in both cell invasion and migration. These radioresistant cells further demonstrated a high metabolic profile, notably marked by lipid metabolism reprogramming and functional enrichment of ATP-binding cassette (ABC) transporters. Consistently, enhanced CSC phenotype in radioresistant cells was confirmed by elevated expression of stemness markers and increased sphere-forming capacity. Conclusion: Radioresistant oral carcinoma cells subjected to fractionated radiation exhibit an augmented malignant phenotype. The metabolic characteristics linked to enhanced EMT and CSC phenotypes provide potential targets for improving radiotherapy in oral carcinoma.
Sprache	Englisch
Erscheinungsdatum	2024-05-03
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	80227-x
ISSN	1879-1506 ; 0003-9969
ISSN (online)	1879-1506
ISSN	0003-9969
DOI	10.1016/j.archoralbio.2024.105988
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Constrained optimal filter design for multi-channel active noise control via convex optimization.

Zhuang, Yongjie / Liu, Yangfan

The Journal of the Acoustical Society of America

2021 Band 150, Heft 4, Seite(n) 2888

Abstract: In many practical multi-channel active noise control (ANC) applications, various constraints need to be satisfied, such as stability, enhancement, etc. One way to enforce these constraints is to add a regularization term to the Wiener filter formulation, ...

Abstract	In many practical multi-channel active noise control (ANC) applications, various constraints need to be satisfied, such as stability, enhancement, etc. One way to enforce these constraints is to add a regularization term to the Wiener filter formulation, which, by tuning only a single parameter, can over satisfy many constraints and degrade the ANC performance. Another approach for non-adaptive ANC filter design that can produce better ANC performance is to directly solve the constrained optimization problem formulated based on the H
Sprache	Englisch
Erscheinungsdatum	2021-10-31
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0006738
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of obesity on outcomes after surgical stabilization of multiple rib fractures: Evidence from the US nationwide inpatient sample.

Liu, Yang-Fan / Chen, Te-Li / Tseng, Ching-Hsueh / Wang, Jen-Yu / Wang, Wen-Ching

PloS one

2024 Band 19, Heft 2, Seite(n) e0299256

Abstract: Background: Obesity is a global health issue with increasing prevalence. Surgical procedures, such as surgical stabilization of rib fractures (SSRF), may be affected by obesity-related complications. The objective of the study is to investigate the ... ...

Abstract	Background: Obesity is a global health issue with increasing prevalence. Surgical procedures, such as surgical stabilization of rib fractures (SSRF), may be affected by obesity-related complications. The objective of the study is to investigate the effects of obesity on SSRF outcomes in multiple rib fractures. Methods: This retrospective study analyzed data from adults aged ≥ 20 years in the Nationwide Inpatient Sample (NIS) database diagnosed with multiple rib fractures who underwent SSRF between 2005 and 2018. It investigated the relationship between obesity and in-patient outcomes, such as discharge status, length of stay (LOS), in-hospital mortality, hospital costs, and adverse events using logistic and linear regression analyses. Results: Analysis of data from 1,754 patients (morbidly obese: 87; obese: 106; normal weight: 1,561) revealed that morbid obesity was associated with longer LOS (aBeta = 0.07, 95% CI: 0.06, 0.07), higher hospital costs (aBeta = 47.35, 95% CI: 38.55, 56.14), increased risks of adverse events (aOR = 1.63, 95% CI: 1.02, 2.61), hemorrhage/need for transfusion (aOR = 1.77, 95% CI: 1.12, 2.79) and mechanical ventilation ≥ 96 hours (aOR = 2.14, 95% CI: 1.28, 3.58) compared to normal weight patients. Among patients with flail chest, morbid obesity was significantly associated with tracheostomy (aOR = 2.13, 95% CI: 1.05, 4.32), ARDS/respiratory failure (aOR = 2.01, 95% CI: 1.09, 3.70), and mechanical ventilation ≥ 96 hours (aOR = 2.80, 95% CI: 1.47, 5.32). In contrast, morbid obesity had no significant associations with these adverse respiratory outcomes among patients without a flail chest (p > 0.05). Conclusions: Morbid obesity is associated with adverse outcomes following SSRF for multiple rib fractures, especially for flail chest patients.
Mesh-Begriff(e)	Adult ; Humans ; Inpatients ; Rib Fractures/complications ; Rib Fractures/surgery ; Obesity, Morbid/complications ; Flail Chest ; Retrospective Studies
Sprache	Englisch
Erscheinungsdatum	2024-02-29
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299256
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DctViT: Discrete Cosine Transform meet vision transformers.

Su, Keke / Cao, Lihua / Zhao, Botong / Li, Ning / Wu, Di / Han, Xiyu / Liu, Yangfan

Neural networks : the official journal of the International Neural Network Society

2024 Band 172, Seite(n) 106139

Abstract: Vision transformers (ViTs) have become one of the dominant frameworks for vision tasks in recent years because of their ability to efficiently capture long-range dependencies in image recognition tasks using self-attention. In fact, both CNNs and ViTs ... ...

Abstract	Vision transformers (ViTs) have become one of the dominant frameworks for vision tasks in recent years because of their ability to efficiently capture long-range dependencies in image recognition tasks using self-attention. In fact, both CNNs and ViTs have advantages and disadvantages in vision tasks, and some studies suggest that the use of both may be an effective way to balance performance and computational cost. In this paper, we propose a new hybrid network based on CNN and transformer, using CNN to extract local features and transformer to capture long-distance dependencies. We also proposed a new feature map resolution reduction based on Discrete Cosine Transform and self-attention, named DCT-Attention Down-sample (DAD). Our DctViT-L achieves 84.8% top-1 accuracy on ImageNet 1K, far outperforming CMT, Next-ViT, SpectFormer and other state-of-the-art models, with lower computational costs. Using DctViT-B as the backbone, RetinaNet can achieve 46.8% mAP on COCO val2017, which improves mAP by 2.5% and 1.1% with less calculation cost compared with CMT-S and SpectFormer as the backbone.
Mesh-Begriff(e)	Image Interpretation, Computer-Assisted
Sprache	Englisch
Erscheinungsdatum	2024-01-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	740542-x
ISSN	1879-2782 ; 0893-6080
ISSN (online)	1879-2782
ISSN	0893-6080
DOI	10.1016/j.neunet.2024.106139
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A method to calculate acoustic radiation modes based on spheroidal wave functions.

Wang, Yiming / Liu, Yangfan / Bolton, J Stuart

JASA express letters

2022 Band 1, Heft 1, Seite(n) 15601

Abstract: Acoustic radiation modes (ARMs) have been widely used in noise control engineering. For an arbitrarily shaped radiator, ARMs are usually obtained by using the boundary element method (BEM). For high frequencies and large structures, the BEM calculation ... ...

Abstract	Acoustic radiation modes (ARMs) have been widely used in noise control engineering. For an arbitrarily shaped radiator, ARMs are usually obtained by using the boundary element method (BEM). For high frequencies and large structures, the BEM calculation is usually time consuming. An alternative method was recently developed in which the ARMs are obtained by using generalized singular value decomposition and spherical harmonic functions. In this paper, spheroidal harmonic functions are used instead of spherical harmonic functions. The proposed method is potentially more efficient for ARM calculations for structures with one dimension significantly larger than the other two.
Sprache	Englisch
Erscheinungsdatum	2022-09-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2691-1191
ISSN (online)	2691-1191
DOI	10.1121/10.0003047
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Clinical Efficacy Comparison of Different Second Line Salvage Chemotherapy Regimens for the Treatment of Elderly Patients with Relapsed and Refractory Diffuse Large B Cell Lymphoma].

Liu, Yang-Fan

Zhongguo shi yan xue ye xue za zhi

2016 Band 24, Heft 2, Seite(n) 448–451

Abstract: Objective: To investigate and compare the clinical effects and safety of DICE regimen combined with rituximab and GDP regimen combined with rituximab for the treatment of elderly patients with relapsed and refractory diffuse large B cell lymphoma.: ... ...

Abstract	Objective: To investigate and compare the clinical effects and safety of DICE regimen combined with rituximab and GDP regimen combined with rituximab for the treatment of elderly patients with relapsed and refractory diffuse large B cell lymphoma. Methods: Ninety elderly patients with relapsed and refractory diffuse large B cell lymphoma were admitted in our hospital from January 2008 to June 2013 and randomly divided into 2 groups, including A group (45 patients) and B group (45 patients), the patients in A group were treated by DICL regimen combined with rituximab, while the patients in B group were treated by GDP regimen combined with rituximab; the clinical efficacy, disease-free survival time, the survival rate with follow-up and the incidence of toxic side-effects in 2 groups were compared. Results: The clinical efficacy of B group was significant better than that of A group (P < 0.05). The disease-free survival time of B group was significantly longer than that of A group (P < 0.05). The survival rate with follow-up of B group was significantly higher than that of A group (P < 0.05). The difference was not significant in incidence of the toxic side effects between 2 groups (P > 0.05). Conclusion: Compared with DICE regimen combined with rituximab, GDP regimen combined with rituximab in treatment of elderly patients with relapsed and refractory diffuse large B cell lymphoma can efficiently reduce tumor loading, prolong the disease-free survival time, improve the long-term clinical prognosis, and not aggravate the side effects of drugs.
Mesh-Begriff(e)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/therapeutic use ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Dexamethasone/therapeutic use ; Disease-Free Survival ; Etoposide/therapeutic use ; Humans ; Ifosfamide/therapeutic use ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Prognosis ; Remission Induction ; Rituximab/therapeutic use ; Salvage Therapy ; Survival Rate ; Treatment Outcome
Chemische Substanzen	Deoxycytidine (0W860991D6) ; Rituximab (4F4X42SYQ6) ; Etoposide (6PLQ3CP4P3) ; Dexamethasone (7S5I7G3JQL) ; Cisplatin (Q20Q21Q62J) ; Ifosfamide (UM20QQM95Y)
Sprache	Chinesisch
Erscheinungsdatum	2016-04
Erscheinungsland	China
Dokumenttyp	Comparative Study ; English Abstract ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.7534/j.issn.1009-2137.2016.02.026
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The Application Effect of Traditional Chinese Medicine Nursing on General Anesthesia Combined with Epidural Anesthesia and Electric Resection for the Treatment of Bladder Cancer and Its Influence on Tumor Markers.

Wu, Yan / Zhang, Zhenna / Liu, Yangfan / Shi, Guangwen / Ding, Xuehai

Evidence-based complementary and alternative medicine : eCAM

2022 Band 2022, Seite(n) 7178711

Abstract: Objective: To explore the effects of traditional Chinese medicine nursing on general anesthesia combined with epidural anesthesia and electric resection to treat bladder cancer and its influence on tumor markers.: Methods: A total of 160 patients ... ...

Abstract	Objective: To explore the effects of traditional Chinese medicine nursing on general anesthesia combined with epidural anesthesia and electric resection to treat bladder cancer and its influence on tumor markers. Methods: A total of 160 patients with non-muscle-invasive bladder cancer who underwent general anesthesia combined with epidural anesthesia and resection were included in this study. The patients were divided into control group ( Results: The total effective rate of the study group (83.75%) was significantly higher than that of the control group (58.75%). After treatment, the serum VEGF and BTA levels, inflammatory factors interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor- Conclusion: Traditional Chinese medicine nursing has significant clinical effects on the treatment of bladder cancer with general anesthesia combined with epidural anesthesia and electric resection. It can more effectively prevent the risk of recurrence of bladder cancer after surgery, significantly improve the quality of life, improve immune system function, regulate the levels of VECF and BTA, effectively reduce the level of serum inflammatory factors, inhibit tumor progression, and reduce tumor viability.
Sprache	Englisch
Erscheinungsdatum	2022-01-15
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7178711
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Risk factors for avian influenza in Danish poultry and wild birds during the epidemic from June 2020 to May 2021.

Liu, Yangfan / Kjær, Lene Jung / Boklund, Anette Ella / Hjulsager, Charlotte Kristiane / Larsen, Lars Erik / Kirkeby, Carsten Thure

Frontiers in veterinary science

2024 Band 11, Seite(n) 1358995

Abstract: Exploring the risk factors of avian influenza (AI) occurrence helps us to monitor and control the disease. Since late 2020, the number of avian influenza outbreaks in domestic and wild birds has increased in most European countries, including Denmark. ... ...

Abstract	Exploring the risk factors of avian influenza (AI) occurrence helps us to monitor and control the disease. Since late 2020, the number of avian influenza outbreaks in domestic and wild birds has increased in most European countries, including Denmark. This study was conducted to identify potential risk factors for wild birds and poultry during the epidemic in 2020/2021 in Denmark. Using Danish AI surveillance data of actively surveyed poultry and passively surveyed wild birds from June 2020 to May 2021, we calculated geographical attributes for bird locations and assessed the potential risk factors of AI detections using logistic regression analyses. 4% of actively surveyed poultry and 39% of passively surveyed wild birds were detected with AI circulating or ongoing at the time. Of these, 10 and 99% tested positive for the H5/H7 AI subtypes, respectively. Our analyses did not find any statistically significant risk factors for actively surveyed poultry within the dataset. For passively surveyed wild birds, bird species belonging to the Anseriformes order had a higher risk of being AI virus positive than five other taxonomic bird orders, and Galliformes were of higher risk than two other taxonomic bird orders. Besides, every 1 km increase in the distance to wetlands was associated with a 5.18% decrease in the risk of being AI positive (OR (odds ratio) 0.95, 95% CI 0.91, 0.99), when all other variables were kept constant. Overall, bird orders and distance to wetlands were associated with the occurrence of AI. The findings may provide targets for surveillance strategies using limited resources and assist in risk-based surveillance during epidemics.
Sprache	Englisch
Erscheinungsdatum	2024-02-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2024.1358995
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma.

Liu, Yangfan / Sun, Yu / Yang, Jin / Wu, Deyang / Yu, Shuang / Liu, Junjiang / Hu, Tao / Luo, Jingjing / Zhou, Hongmei

Molecular cancer

2024 Band 23, Heft 1, Seite(n) 104

Abstract: Background: The faithful maintenance of DNA methylation homeostasis indispensably requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squamous cell carcinoma (OSCC). ... ...

Abstract	Background: The faithful maintenance of DNA methylation homeostasis indispensably requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squamous cell carcinoma (OSCC). However, how the DNMT1- associated global DNA methylation is exploited to regulate OSCC remains unclear. Methods: The shRNA-specific DNMT1 knockdown was employed to target DNMT1 on oral cancer cells in vitro, as was the use of DNMT1 inhibitors. A xenografted OSCC mouse model was established to determine the effect on tumor suppression. High-throughput microarrays of DNA methylation, bulk and single-cell RNA sequencing analysis, multiplex immunohistochemistry, functional sphere formation and protein immunoblotting were utilized to explore the molecular mechanism involved. Analysis of human samples revealed associations between DNMT1 expression, global DNA methylation and collaborative molecular signaling with oral malignant transformation. Results: We investigated DNMT1 expression boosted steadily during oral malignant transformation in human samples, and its inhibition considerably minimized the tumorigenicity in vitro and in a xenografted OSCC model. DNMT1 overexpression was accompanied by the accumulation of cancer-specific DNA hypomethylation during oral carcinogenesis; conversely, DNMT1 knockdown caused atypically extensive genome-wide DNA hypomethylation in cancer cells and xenografted tumors. This novel DNMT1-remodeled DNA hypomethylation pattern hampered the dual activation of PI3K-AKT and CDK2-Rb and inactivated GSK3β collaboratively. When treating OSCC mice, targeting DNMT1 achieved greater anticancer efficacy than the PI3K inhibitor, and reduced the toxicity of blood glucose changes caused by the PI3K inhibitor or combination of PI3K and CDK inhibitors as well as adverse insulin feedback. Conclusions: Targeting DNMT1 remodels a novel global DNA hypomethylation pattern to facilitate anticancer efficacy and minimize potential toxic effects via balanced signaling synergia. Our study suggests DNMT1 is a crucial gatekeeper regarding OSCC destiny and treatment outcome.
Mesh-Begriff(e)	Humans ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors ; Animals ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Mouth Neoplasms/metabolism ; Mice ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/metabolism ; Signal Transduction ; Cell Proliferation
Chemische Substanzen	DNMT1 protein, human
Sprache	Englisch
Erscheinungsdatum	2024-05-16
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-024-01993-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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