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Artikel: Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study

Lorbeer, Roberto / Rathmann, Wolfgang

PLOS ONE, 12(9):e0184858

2017

Abstract: OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged ... ...

Körperschaft	Deutsches Diabetes-Zentrum
Abstract	OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the “Kooperative Gesundheitsforschung in der Region Augsburg” (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided. RESULTS: Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5). CONCLUSIONS: In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes.
Schlagwörter	Cardiovascular diseases ; Carotid arteries ; Central nervous system ; Glucose metabolism ; Diabetes mellitus ; Magnetic resonance imaging ; Stroke ; Vertigo
Sprache	Englisch
Dokumenttyp	Artikel
Datenquelle	Fachrepositorium Lebenswissenschaften

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Buch ; Online ; Dissertation / Habilitation: Magnetic resonance imaging measures of vascular structure and adipose tissue: relations to cardiovascular risk factors in the general population

Lorbeer, Roberto [Verfasser]

2022

Verfasserangabe	Roberto Lorbeer
Schlagwörter	Medizin, Gesundheit ; Medicine, Health
Thema/Rubrik (Code)	sg610
Sprache	Englisch
Verlag	Universitätsbibliothek der Ludwig-Maximilians-Universität
Erscheinungsort	München
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Datenquelle	Digitale Dissertationen im Internet

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Artikel: Age- and Sex-Specific Reference Values for Renal Volume and Association with Risk Factors for Chronic Kidney Disease in a General Population-An MRI-Based Study.

Dabers, Thomas / Sass, Peter / Fechner, Fritz / Weyer, Julian / Völzke, Henry / Mahnken, Andreas Horst / Lorbeer, Roberto / Mensel, Birger / Stracke, Sylvia

Journal of clinical medicine

2024 Band 13, Heft 3

Abstract: Background: Renal volume (RV) is associated with renal function and with a variety of cardiovascular risk factors (CVRFs). We analysed RV using magnetic resonance imaging (MRI) in a large population-based study (Study of Health in Pomerania; SHIP-TREND) ...

Abstract	Background: Renal volume (RV) is associated with renal function and with a variety of cardiovascular risk factors (CVRFs). We analysed RV using magnetic resonance imaging (MRI) in a large population-based study (Study of Health in Pomerania; SHIP-TREND) to find sex- and age-specific reference values for RV and to test the influence of several markers on RV. The main objective is to describe reference values for RV in people from the general population without kidney disease. Methods: 1815 participants without kidney disease (930 women) aged 21-81 years were included in our study. Right and left RV with and without body surface area (BSA) indexation were compared among three age groups (22-39 years, 40-59 years, 60-81 years) by median and interquartile range and tested separately in women and men. Results: The estimated glomerular filtration rate (eGFR), serum uric acid, and right and left RV were higher in men compared to women (all Conclusion: Reference values for RV are different for age groups and sex. For any given age, female kidneys are smaller than male kidneys. RV associates positively with eGFR, but for any chosen eGFR, renal volume in females is lower compared to males. RV decreases with age, but in men showed a U-shaped correlation. This may reflect hyperfiltration and glomerular hypertrophy associated with the presence of CVRF in middle-aged males.
Sprache	Englisch
Erscheinungsdatum	2024-01-29
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030769
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Association between Large Arteries Diameter and Heart Function in Subjects Free of Cardiovascular Diseases.

von Krüchten, Ricarda / Lorbeer, Roberto / Peters, Annette / Bamberg, Fabian / Schlett, Christopher L / Mujaj, Blerim

Journal of personalized medicine

2022 Band 12, Heft 6

Abstract: To investigate the association between Aorta (Ao), pulmonary artery (PA) diameters and the PA/Ao ratio with right (RV) and left ventricle (LV) volumetric properties in subjects free of cardiovascular diseases. In the KORA-MRI study, 339 subjects (mean ... ...

Abstract	To investigate the association between Aorta (Ao), pulmonary artery (PA) diameters and the PA/Ao ratio with right (RV) and left ventricle (LV) volumetric properties in subjects free of cardiovascular diseases. In the KORA-MRI study, 339 subjects (mean age 56.3 ± 9.1 years; 43.7% female) underwent whole-body 3T-MRI. Ao and PA were measured on DIXON sequences. Cvi42 quantified cardiac functional parameters from a SSFP sequence. The relationship between ascending (AAo), and descending aorta (DAo), as well as PA diameters, and RV and LV function were assessed using linear regression models adjusted for age, sex, and cardiovascular risk factors. AAo and DAo diameter were associated with LV end-diastolic volume (β = 4.52,
Sprache	Englisch
Erscheinungsdatum	2022-05-28
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12060889
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Native myocardial T1 mapping: influence of spatial resolution on quantitative results and reproducibility.

Dalmer, Antonia / Meinel, Felix G / Böttcher, Benjamin / Manzke, Mathias / Lorbeer, Roberto / Weber, Marc-André / Baeßler, Bettina / Klemenz, Ann-Christin

Quantitative imaging in medicine and surgery

2023 Band 14, Heft 1, Seite(n) 20–30

Abstract: Background: Myocardial mapping techniques can be used to quantitatively assess alterations in myocardial tissue properties. This study aims to evaluate the influence of spatial resolution on quantitative results and reproducibility of native myocardial ... ...

Abstract	Background: Myocardial mapping techniques can be used to quantitatively assess alterations in myocardial tissue properties. This study aims to evaluate the influence of spatial resolution on quantitative results and reproducibility of native myocardial T1 mapping in cardiac magnetic resonance imaging (MRI). Methods: In this cross-sectional study with prospective data collection between October 2019 and February 2020, 50 healthy adults underwent two identical cardiac MRI examinations in the radiology department on the same day. T1 mapping was performed using a MOLLI 5(3)3 sequence with higher (1.4 mm × 1.4 mm) and lower (1.9 mm × 1.9 mm) in-plane spatial resolution. Global quantitative results of T1 mapping were compared between high-resolution and low-resolution acquisitions using paired Results: There was no significant difference between global quantitative results acquired with high Conclusions: Based on our data, we recommend a spatial resolution on the order of 1.9 mm × 1.9 mm for native myocardial T1 mapping using a MOLLI 5(3)3 sequence at 1.5 T particularly in individuals with higher heart rates and women.
Sprache	Englisch
Erscheinungsdatum	2023-11-14
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-943
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Utility of clinical and MR imaging parameters for prediction and monitoring of response to capecitabine and temozolomide (CAPTEM) therapy in patients with liver metastases of neuroendocrine tumors.

Ingenerf, Maria / Auernhammer, Christoph / Lorbeer, Roberto / Winkelmann, Michael / Mansournia, Shiwa / Mansour, Nabeel / Hesse, Nina / Heinrich, Kathrin / Ricke, Jens / Berger, Frank / Schmid-Tannwald, Christine

Radiology and oncology

2024

Abstract: Background: This study explores the predictive and monitoring capabilities of clinical and multiparametric MR parameters in assessing capecitabine and temozolomide (CAPTEM) therapy response in patients with neuroendocrine tumors (NET).: Patients and ... ...

Abstract	Background: This study explores the predictive and monitoring capabilities of clinical and multiparametric MR parameters in assessing capecitabine and temozolomide (CAPTEM) therapy response in patients with neuroendocrine tumors (NET). Patients and methods: This retrospective study (n = 44) assessed CAPTEM therapy response in neuroendocrine liver metastases (NELM) patients. Among 33 monitored patients, as a subgroup of the overall study cohort, pretherapeutic and follow-up MRI data (size, apparent diffusion coefficient [ADC] values, and signal intensities), along with clinical parameters (chromogranin A [CgA] and Ki-67%), were analyzed. Progression-free survival (PFS) served as the reference. Responders were defined as those with PFS ≥ 6 months. Results: Most patients were male (75%) and had G2 tumors (76%) with a pancreatic origin (84%). Median PFS was 5.7 months; Overall Survival (OS) was 25 months. Non-responders (NR) had higher Ki-67 in primary tumors (16.5 Conclusions: Survival analysis emphasizes the need for adapted response criteria, involving combined evaluation of CgA, ADC values, and tumor size for monitoring CAPTEM response in hepatic metastasized NETs.
Sprache	Englisch
Erscheinungsdatum	2024-04-14
Erscheinungsland	Poland
Dokumenttyp	Journal Article
ZDB-ID	1128829-2
ISSN	1581-3207 ; 0485-893X ; 1318-2099
ISSN (online)	1581-3207
ISSN	0485-893X ; 1318-2099
DOI	10.2478/raon-2024-0024
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment.

Krüchten, Ricarda von / Rospleszcz, Susanne / Lorbeer, Roberto / Hasic, Dunja / Peters, Annette / Bamberg, Fabian / Schulz, Holger / Karrasch, Stefan / Schlett, Christopher L

Tomography (Ann Arbor, Mich.)

2022 Band 8, Heft 2, Seite(n) 560–569

Abstract: Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent whole-body MRI and pulmonary ... ...

Abstract	Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent whole-body MRI and pulmonary function tests as part of the KORA (Cooperative Health Research in the Augsburg Region) MRI study. Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were derived from the T1-Dixon sequence, and hepatic adipose tissue from the proton density fat fraction (PDFFhepatic). Associations between adipose tissue parameters and spirometric indices such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and Tiffeneau-index (FEV1/FVC) were examined using multivariate linear regression analysis excluding cofounding effects of other clinical parameters. Results: VAT (β = −0.13, p = 0.03) and SAT (β = −0.26, p < 0.001), but not PDFFhepatic were inversely associated with FEV1, while VAT (β = −0.27, p < 0.001), SAT (β = −0.41, p < 0.001), and PDFFhepatic (β = −0.17, p = 0.002) were inversely associated with FVC. PDFFhepatic was directly associated with the Tiffeneau index (β = 2.46, p < 0.001). Conclusions: In the adjusted linear regression model, VAT was inversely associated with all measured spirometric parameters, while PDFFhepatic revealed the strongest association with the Tiffeneau index. Non-invasive adipose tissue quantification measurements might serve as novel biomarkers for respiratory impairment.
Mesh-Begriff(e)	Adipose Tissue/diagnostic imaging ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Subcutaneous Fat ; Whole Body Imaging
Sprache	Englisch
Erscheinungsdatum	2022-02-27
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography8020046
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online ; Dissertation / Habilitation: Endocrine-metabolic markers and subclinical cardiovascular disorders

Lorbeer, Roberto [Verfasser]

2012

Verfasserangabe	Roberto Lorbeer
Schlagwörter	Medizin, Gesundheit ; Medicine, Health
Thema/Rubrik (Code)	sg610
Sprache	Englisch
Verlag	Universitätsbibliothek Greifswald
Erscheinungsort	Greifswald
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Datenquelle	Digitale Dissertationen im Internet

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Artikel ; Online: Adipose tissue is associated with kidney function parameters.

Mueller-Peltzer, Katharina / von Krüchten, Ricarda / Lorbeer, Roberto / Rospleszcz, Susanne / Schulz, Holger / Peters, Annette / Bamberg, Fabian / Schlett, Christopher L / Mujaj, Blerim

Scientific reports

2023 Band 13, Heft 1, Seite(n) 9151

Abstract: Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether adipose tissue directly affects kidney function is still unknown. We aimed to investigate the role of the adipose tissue and circulating creatinine, ... ...

Abstract	Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether adipose tissue directly affects kidney function is still unknown. We aimed to investigate the role of the adipose tissue and circulating creatinine, cystatin C and kidney function in subjects free of cardio-renal diseases. In the KORA-MRI population-based study, 377 subjects (mean age 56.2 ± 9.2 years; 41.6% female) underwent whole-body 3T-MRI examination. Adipose tissue defined as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were quantified from T1-DIXON sequence using a semi-automatic algorithm. Serum creatinine and cystatin C were measured using standard laboratory and estimated glomerular filtration rate (e-GFR) was performed based on creatinine (e-GFR
Mesh-Begriff(e)	Humans ; Female ; Middle Aged ; Aged ; Male ; Creatinine ; Cystatin C ; Risk Factors ; Glomerular Filtration Rate ; Obesity ; Subcutaneous Fat/diagnostic imaging ; Kidney/diagnostic imaging
Chemische Substanzen	Creatinine (AYI8EX34EU) ; Cystatin C
Sprache	Englisch
Erscheinungsdatum	2023-06-06
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36390-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Association between dietary fat intake and MRI-determined visceral, subcutaneous, or hepatic fat in men and women from the general population

Meisinger, Christa / Rospleszcz, Susanne / Wintermeyer, Elke / Lorbeer, Roberto / Thorand, Barbara / Bamberg, Fabian / Peters, Annette / Schlett, Christopher / Linseisen, Jakob

Proceedings of the Nutrition Society. 2020, v. 79, no. OCE2

2020

Abstract: An increase in dietary fat intake - at the expense of dietary carbohydrate intake - may play an important role in the accumulation of adipose tissue at different sites and liver fat accumulation. Thus, the present study investigated the isocaloric ... ...

Abstract	An increase in dietary fat intake - at the expense of dietary carbohydrate intake - may play an important role in the accumulation of adipose tissue at different sites and liver fat accumulation. Thus, the present study investigated the isocaloric substitution of dietary carbohydrates with fat, and its cross-sectional association with visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and hepatic fat content as determined by MRI. Data from 283 participants (mean age 56.1 ± 9.0 years) from the KORA FF4 study study who underwent whole-body MRI were included. VAT, SAT, and total body fat were quantified by a volume-interpolated VIBE-T1w-Dixon MR sequence. Hepatic fat content was determined as the proton density fat-fraction (PDFF) derived from multiecho-T1w MR sequence. Habitual dietary intake was estimated by combining the information provided by repeated 24-h food lists and a food frequency questionnaire. Cross-sectional associations were analyzed using linear regressions. Carbohydrate intake (in % of total energy intake (E%)) correlated significantly inversely with VAT (r = -0.34) and hepatic fat (r = -0,30), while fat intake (E%) correlated positively with hepatic fat content (r = 0.16). Replacing total carbohydrates with an isocaloric amount of total fat was significantly positively associated with VAT and hepatic fat, while there was no significant association with SAT. The multivariable adjusted β-coefficient for replacing 5 E% carbohydrates with total fat was 0.39 (95% CI: 0.02, 0.76) for VAT. An increase in total fat intake by 5% of total energy was associated with an increase in liver fat content by 24%. Dietary fiber intake was significantly inversely associated with VAT and hepatic lipid content. In middle-aged adults, substitution of carbohydrates with total fat was associated with a higher volume of VAT and an increase of hepatic fat, while whole-grain associated carbohydrates show inverse associations. If reproduced in prospective studies, such findings would strongly argue for limiting dietary fat intake.
Schlagwörter	adipose tissue ; body fat ; carbohydrate intake ; dietary carbohydrate ; dietary fiber ; energy intake ; fat intake ; food frequency questionnaires ; food intake ; lipid content ; liver ; whole grain foods
Sprache	Englisch
Erscheinungsort	Cambridge University Press
Dokumenttyp	Artikel
Anmerkung	NAL-AP-2-clean
ZDB-ID	391142-1
ISSN	1475-2719 ; 0029-6651
ISSN (online)	1475-2719
ISSN	0029-6651
DOI	10.1017/S0029665120006035
Datenquelle	NAL Katalog (AGRICOLA)

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