Article ; Online: N-Acetylglucosamine mitigates lung injury and pulmonary fibrosis induced by bleomycin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2023 Volume 166, Page(s) 115069
Abstract: Lung injury and pulmonary fibrosis contribute to morbidity and mortality, and, in particular, are characterized as leading cause on confirmed COVID-19 death. To date, efficient therapeutic approach for such lung diseases is lacking. N-Acetylglucosamine ( ... ...
| Abstract | Lung injury and pulmonary fibrosis contribute to morbidity and mortality, and, in particular, are characterized as leading cause on confirmed COVID-19 death. To date, efficient therapeutic approach for such lung diseases is lacking. N-Acetylglucosamine (NAG), an acetylated derivative of glucosamine, has been proposed as a potential protector of lung function in several types of lung diseases. The mechanism by which NAG protects against lung injury, however, remains unclear. Here, we show that NAG treatment improves pulmonary function in bleomycin (BLM)-induced lung injury model measured by flexiVent system. At early phase of lung injury, NAG treatment results in silenced immune response by targeting ARG1 |
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| MeSH term(s) | Humans ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/prevention & control ; Lung Injury/chemically induced ; Lung Injury/drug therapy ; Acetylglucosamine ; Bleomycin/toxicity ; COVID-19 | |||||
| Chemical Substances | Acetylglucosamine (V956696549) ; Bleomycin (11056-06-7) | |||||
| Language | English | |||||
| Publishing date | 2023-08-24 | |||||
| Publishing country | France | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 392415-4 | |||||
| ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 | |||||
| ISSN (online) | 1950-6007 | |||||
| ISSN | 0753-3322 ; 0300-0893 | |||||
| DOI | 10.1016/j.biopha.2023.115069 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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