Artikel: Peanut allergy and oral immunotherapy.
Hong Kong medical journal = Xianggang yi xue za zhi
2019 Band 25, Heft 3, Seite(n) 228–234
Abstract: Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-immunoglobulin E ...
Abstract | Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-immunoglobulin E and oral immunotherapy. We have treated 27 patients with anti-immunoglobulin E and oral immunotherapy, and report on the outcomes and incidence of adverse reactions encountered during treatment. The dose of peanut protein tolerated increased from a median baseline of 5 to 2000 mg after desensitisation, which is substantially more than would be encountered through accidental ingestion. The incidence of adverse reactions during the escalation phase of oral immunotherapy was 1.8%, and that during the maintenance phase was 0.6%. Most adverse reactions were mild; three episodes were severe enough to warrant withdrawal from oral immunotherapy, but none required epinephrine injection. Preliminary data suggest that unresponsiveness is lost when daily ingestion of peanuts is stopped after the maintenance period. |
---|---|
Mesh-Begriff(e) | Administration, Oral ; Adolescent ; Allergens/administration & dosage ; Allergens/immunology ; Arachis/immunology ; Child ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Epinephrine/therapeutic use ; Female ; Histamine H1 Antagonists/therapeutic use ; Humans ; Immunologic Factors/adverse effects ; Male ; Peanut Hypersensitivity/immunology ; Peanut Hypersensitivity/therapy |
Chemische Substanzen | Allergens ; Histamine H1 Antagonists ; Immunologic Factors ; Epinephrine (YKH834O4BH) |
Sprache | Englisch |
Erscheinungsdatum | 2019-06-10 |
Erscheinungsland | China |
Dokumenttyp | Journal Article |
ZDB-ID | 1239255-8 |
ISSN | 1024-2708 |
ISSN | 1024-2708 |
DOI | 10.12809/hkmj187743 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 4347: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.