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  1. Buch ; Dissertation / Habilitation: Lokalisation von Estrogen-bindenden Proteinen im akzessorischen chemosensorischen System des Menschen

    Maximov, Maxim / Jirikowski, Gustav / Lupp, Amelie / Witt, Martin

    2022  

    Körperschaft Friedrich-Schiller-Universität Jena
    Verfasserangabe von Maxim Maximov
    Schlagwörter Sinneszelle ; Östrogene ; Pheromon
    Schlagwörter Ektohormon ; Follikelhormone ; Estrogene ; Östrogen
    Sprache Deutsch ; Englisch
    Umfang 64 Blätter, Illustrationen, Diagramme, 64 Blätter
    Erscheinungsort Jena
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Friedrich-Schiller-Universität Jena, 2022
    Anmerkung Tag der Verteidigung: 04.01.2022
    HBZ-ID HT021364473
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch ; Dissertation / Habilitation: Untersuchungen zum Zusammenhang zwischen Nierenfunktion und renaler 68Ga-DOTATOC- Speicherung unter besonderer Berücksichtigung der Relevanz für die peptidvermittelte Radiorezeptortherapie mit 177Lu-DOTATOC

    Heinzig, Alexander / Busch, Martin / Lupp, Amelie / Kotzerke, Jörg

    2023  

    Titelvarianten achtundsechzig einhundertsiebenundsiebzig
    Körperschaft Friedrich-Schiller-Universität Jena
    Verfasserangabe von Alexander Heinzig
    Sprache Deutsch
    Umfang 80 Seiten, Illustrationen, Diagramme, 30 cm
    Erscheinungsort Jena
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Anmerkung Tag der Verteidigung: 05.09.2023
    HBZ-ID HT030617162
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Buch ; Dissertation / Habilitation: Expression von Dopamin-D2-Rezeptoren in gastroenteropankreatischen und bronchopulmonalen neuroendokrinen Neoplasien

    Mandel, Morlin / Lupp, Amelie / Kämmerer, Daniel / Raderer, Markus

    2022  

    Körperschaft Friedrich-Schiller-Universität Jena
    Verfasserangabe von Morlin Elna Mandel
    Schlagwörter Neuroendokriner Tumor ; Somatostatin ; Dopaminrezeptor
    Schlagwörter Stilamin
    Sprache Deutsch
    Umfang 90 Blätter, Illustrationen, Diagramme, 29,5 cm
    Erscheinungsort Jena
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Friedrich-Schiller-Universität Jena, 2022
    HBZ-ID HT021571012
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch ; Dissertation / Habilitation: Immunhistochemische Untersuchung der Expression des Corticotropin-Releasing-Hormon-Rezeptors 1 mit Hilfe eines neuen monoklonalen Kaninchen-Antikörpers

    Schlee, Sven / Lupp, Amelie / Jirikowski, Gustav / Franke, Heike

    2022  

    Titelvarianten eins
    Körperschaft Friedrich-Schiller-Universität Jena
    Verfasserangabe von Sven Armin Schlee
    Schlagwörter Corticoliberin ; Hormon ; Antikörper ; Kaninchen
    Schlagwörter Hauskaninchen ; Stallhase ; Hormone ; Corticotropin-Releasinghormon ; CRH ; CRF ; Corticotropin releasing factor ; Corticotrophin releasing hormone
    Sprache Deutsch
    Umfang V, 112 Seiten, Illustrationen, Diagramme, 21 cm
    Erscheinungsort Jena
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Friedrich-Schiller-Universität Jena, 2022
    Anmerkung Tag der Verteidigung: 05.07.2022
    HBZ-ID HT021687163
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Buch ; Dissertation / Habilitation: Vergleichende Untersuchung der Expression verschiedener Neuropeptid-Rezeptoren in neuroendokrinen Tumoren und Adenokarzinomen des Pankreas

    Kajtazi, Ylberta / Lupp, Amelie / Kämmerer, Daniel / Kleeff, Jörg H.

    2022  

    Körperschaft Friedrich-Schiller-Universität Jena
    Verfasserangabe von Ylberta Kajtazi
    Sprache Deutsch
    Umfang VIII, 127 Blätter, Illustrationen, Diagramme, 30 cm
    Erscheinungsort Jena
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Friedrich-Schiller-Universität Jena, 2022
    Anmerkung Tag der Verteidigung: 06.12.2022
    HBZ-ID HT030008055
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  6. Buch ; Dissertation / Habilitation: Pharmakologische, biochemische und morphologische Charakterisierung fetaler Lebergewebetransplantate in der Milz im Vergleich zur Leber bei der Ratte

    Lupp, Amelie

    2004  

    Verfasserangabe von Amelie Irene Lupp
    Sprache Deutsch
    Umfang 328 Bl., Ill., graph. Darst.
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Jena, Univ., Habil.-Schr., 2004
    HBZ-ID HT015946275
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  7. Artikel ; Online: Expression of free fatty acid receptor 2 in normal and neoplastic tissues.

    Ruhnke, Niklas / Beyer, Anna-Sophia Liselott / Kaemmerer, Daniel / Sänger, Jörg / Schulz, Stefan / Lupp, Amelie

    Experimental and molecular pathology

    2024  Band 137, Seite(n) 104902

    Abstract: Objective: Little information is available concerning protein expression of the free fatty acid receptor 2 (FFAR2), especially in tumours. Therefore, the aim of the present study was to comprehensively characterise the expression profile of FFAR2 in a ... ...

    Abstract Objective: Little information is available concerning protein expression of the free fatty acid receptor 2 (FFAR2), especially in tumours. Therefore, the aim of the present study was to comprehensively characterise the expression profile of FFAR2 in a large series of human normal and neoplastic tissues using immunohistochemistry thus providing a basis for further in-depth investigations into its potential diagnostic or therapeutic importance.
    Methods: We developed a novel rabbit polyclonal anti-FFAR2 antibody, 0524, directed against the C-terminal region of human FFAR2. Antibody specificity was confirmed via Western blot analyses and immunocytochemistry using the FFAR2-expressing cell line BON-1 and FFAR2-specific small interfering RNA as well as native and FFAR2-transfected HEK-293 cells. The antibody was then used for immunohistochemical analyses of various formalin-fixed, paraffin-embedded specimens of normal and neoplastic human tissues.
    Results: In normal tissues, FFAR2 was mainly present in distinct cell populations of the cerebral cortex, follicular cells and C cells of the thyroid, cardiomyocytes of the heart, bronchial epithelia and glands, hepatocytes and bile duct epithelia of the liver, gall bladder epithelium, exocrine and β-cells of the endocrine pancreas, glomerular mesangial cells and podocytes as well as collecting ducts of the kidney, intestinal mucosa (particularly enteroendocrine cells), prostate epithelium, seminiferous tubules of the testicles, and placental syncytiotrophoblasts. In neoplastic tissues, FFAR2 was particularly prevalent in papillary thyroid carcinomas, parathyroid adenomas, and gastric, colon, pancreatic, hepatocellular, cholangiocellular, urinary bladder, breast, cervical, and ovarian carcinomas.
    Conclusions: We generated and characterised a novel rabbit polyclonal anti-human FFAR2 antibody that is well-suited for visualising FFAR2 expression in human routine pathology tissues. This antibody is also suitable for Western blot and immunocytochemistry experiments. To our knowledge, this antibody enabled the first broad FFAR2 protein expression profile in various normal and neoplastic human tissues.
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1016/j.yexmp.2024.104902
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch ; Dissertation / Habilitation: Auto- und Heterorezeptoren and serotonergen Nervenendigungen

    Lupp, Amelie

    1991  

    Verfasserangabe vorgelegt von Amelie Lupp
    Umfang 127 Bl. : Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Freiburg im Breisgau Univ., Diss., 1991
    HBZ-ID HT003969531
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  9. Buch ; Online ; Dissertation / Habilitation: Untersuchung der Expression der Arginin-Vasopressin-Rezeptoren 1a und 2 in menschlichen Normal- und Tumorgeweben mit Hilfe von neuen monoklonalen Antikörpern

    Bursian, Kristina [Verfasser] / Lupp, Amelie [Gutachter] / Kämmerer, Daniel [Gutachter] / Franke, Heike [Gutachter]

    2024  

    Verfasserangabe Kristina Bursian ; Gutachter: Amelie Lupp, Daniel Kämmerer, Heike Franke
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Friedrich-Schiller-Universität Jena
    Erscheinungsort Jena
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  10. Artikel: Evaluation of PD-L1 expression in a large set of gastroenteropancreatic neuroendocrine tumours and correlation with clinicopathological data.

    Rösner, Erik / Kaemmerer, Daniel / Sänger, Jörg / Lupp, Amelie

    Translational oncology

    2022  Band 25, Seite(n) 101526

    Abstract: Background: Targeting programmed death protein 1 (PD-1) or its ligand PD-L1 is a promising therapeutic approach for many types of cancer in which PD-L1 is overexpressed. However, data on PD-L1 expression levels in gastroenteropancreatic neuroendocrine ... ...

    Abstract Background: Targeting programmed death protein 1 (PD-1) or its ligand PD-L1 is a promising therapeutic approach for many types of cancer in which PD-L1 is overexpressed. However, data on PD-L1 expression levels in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are limited and contradictory.
    Methods: We evaluated PD-L1 expression in 457 archived, formalin-fixed, paraffin-embedded GEP-NEN samples from 175 patients by immunohistochemistry using the highly sensitive monoclonal anti-PD-L1 antibody 73-10. The immunostaining was semiquantitatively evaluated using a 12-point immunoreactivity score (IRS) taking both PD-L1-positive tumour cells and immune cells into account. Tumour samples with an IRS ≥ 3 were considered PD-L1-positive. Results were correlated with clinicopathological data and with the expression of several typical markers and receptors for neuroendocrine tumours.
    Results: Of the GEP-NEN samples, 73% were PD-L1-positive. The median IRS value across all samples was 4.0, corresponding to low expression. PD-L1 immunostaining was predominantly localised at the plasma membrane of the tumour cells. Positive correlations were observed between PD-L1 expression and tumour grading or Ki-67 index, between PD-L1 expression and the expression of chromogranin A, and between PD-L1 expression and the expression of each of the five somatostatin receptors. PD-L1 expression was lower in tumours with lymph node metastases at diagnosis than in those without regional metastasis and lower in high-stage than in earlier-stage tumours. No association was noted between PD-L1 expression and patient survival.
    Conclusions: PD-L1 expression is common in GEP-NENs and increases with malignancy. Therefore, especially in high-grade GEP-NENs, targeting the PD-1/PD-L1 axis could be a promising additional therapeutic strategy.
    Sprache Englisch
    Erscheinungsdatum 2022-09-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2022.101526
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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