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  1. AU="Lykke M Ørnbjerg"
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  1. Artikel ; Online: Analysing and reporting of observational data

    Bruno Fautrel / Tanja A Stamm / Ziga Rotar / Delphine S Courvoisier / Maarten de Wit / Sytske Anne Bergstra / Simon R Stones / Joanna Kedra / Anja Strangfeld / Kimme L Hyrich / Lykke M Ørnbjerg

    RMD Open, Vol 7, Iss

    a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology

    2021  Band 3

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.

    Joanna E Cobb / Darren Plant / Edward Flynn / Meriem Tadjeddine / Philippe Dieudé / François Cornélis / Lisbeth Ärlestig / Solbritt Rantapää Dahlqvist / George Goulielmos / Dimitrios T Boumpas / Prodromos Sidiropoulos / Sophine B Krintel / Lykke M Ørnbjerg / Merete L Hetland / Lars Klareskog / Thomas Haeupl / Andrew Filer / Christopher D Buckley / Karim Raza /
    Torsten Witte / Reinhold E Schmidt / Oliver FitzGerald / Douglas Veale / Stephen Eyre / Jane Worthington

    PLoS ONE, Vol 8, Iss 6, p e

    2013  Band 66456

    Abstract: Objectives Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance ...

    Abstract Objectives Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA. Methods A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data. Results Significant evidence of association was detected for nine SNPs within the European samples. When meta-analysed with previously published data, 21 SNPs were associated with RA susceptibility. Although SNPs in the PTPN2 gene were previously reported to be associated with RA in both Japanese and European populations, we show genome-wide evidence for a different SNP within this gene associated with RA susceptibility in an independent European population (rs7234029, P = 4.4×10(-9)). Conclusions This study provides further genome-wide evidence for the association of the PTPN2 locus (encoding the T cell protein tyrosine phosphastase) with Caucasian RA susceptibility. This finding adds to the growing evidence for PTPN2 being a pan-autoimmune susceptibility gene.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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