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  1. Artikel: A High-Throughput Metabolic Microarray Assay Reveals Antibacterial Effects of Black and Red Raspberries and Blackberries against

    Goodman, Candace / Lyon, Katrina N / Scotto, Aitana / Smith, Cyra / Sebrell, Thomas A / Gentry, Andrew B / Bala, Ganesh / Stoner, Gary D / Bimczok, Diane

    Antibiotics (Basel, Switzerland)

    2021  Band 10, Heft 7

    Abstract: Helicobacter ... ...

    Abstract Helicobacter pylori
    Sprache Englisch
    Erscheinungsdatum 2021-07-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10070845
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection.

    Hashimi, Marziah / Sebrell, T Andrew / Hedges, Jodi F / Snyder, Deann / Lyon, Katrina N / Byrum, Stephanie D / Mackintosh, Samuel G / Crowley, Dan / Cherne, Michelle D / Skwarchuk, David / Robison, Amanda / Sidar, Barkan / Kunze, Anja / Loveday, Emma K / Taylor, Matthew P / Chang, Connie B / Wilking, James N / Walk, Seth T / Schountz, Tony /
    Jutila, Mark A / Bimczok, Diane

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 6882

    Abstract: Bats are natural reservoirs for several zoonotic viruses, potentially due to an enhanced capacity to control viral infection. However, the mechanisms of antiviral responses in bats are poorly defined. Here we established a Jamaican fruit bat (JFB, ... ...

    Abstract Bats are natural reservoirs for several zoonotic viruses, potentially due to an enhanced capacity to control viral infection. However, the mechanisms of antiviral responses in bats are poorly defined. Here we established a Jamaican fruit bat (JFB, Artibeus jamaicensis) intestinal organoid model of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Upon infection with SARS-CoV-2, increased viral RNA and subgenomic RNA was detected, but no infectious virus was released, indicating that JFB organoids support only limited viral replication but not viral reproduction. SARS-CoV-2 replication was associated with significantly increased gene expression of type I interferons and inflammatory cytokines. Interestingly, SARS-CoV-2 also caused enhanced formation and growth of JFB organoids. Proteomics revealed an increase in inflammatory signaling, cell turnover, cell repair, and SARS-CoV-2 infection pathways. Collectively, our findings suggest that primary JFB intestinal epithelial cells mount successful antiviral interferon responses and that SARS-CoV-2 infection in JFB cells induces protective regenerative pathways.
    Mesh-Begriff(e) Animals ; COVID-19 ; Chiroptera ; SARS-CoV-2 ; Jamaica ; Viruses ; Interferon Type I ; Antiviral Agents ; Organoids
    Chemische Substanzen Interferon Type I ; Antiviral Agents
    Sprache Englisch
    Erscheinungsdatum 2023-10-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42610-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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